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To study the effect of Xiaoer Xiaoji Zhike Oral Liquid combined with budesonide on serum interferon-γ (IFN-γ), interleukin-4 (IL-4), transforming growth factor β1 (TGF-β1), nitric oxide (NO) level in children with bronchial asthma. Selected 67 cases of patients with bronchial asthma who were treated in our hospital from January 2018 to December 2019, divided into two groups randomly. The control group was treated with budesonide alone, and the observation group was treated with Xiaoer Xiaoji Zhike Oral Liquid combined with budesonide. The effective rate of the observation group 93.94 % was significantly higher than that of the control group 70.59 % (P<0.05). The disappearance time of wheezing, cough disappearance, hospital stay and wheezing disappearance time of the observation group were significantly shorter than control group (P<0.05). After treatment, the levels of serum NO and IL-4 of the two groups of children were significantly reduced (P<0.05), and the levels of serum TGF-β1 and IFN-γ were significantly increased (P<0.05), and the levels of serum NO and IL-4 in the observation group The level of IL-4 was significantly lower than that of the control group (P<0.05), and the levels of serum TGF-β1 and IFN-γ were significantly higher than that of the control group (P<0.05). After treatment, the serum IgM, IgA and IgG levels of the two groups of children were significantly reduced (P<0.05), and the serum IgM, IgA and IgG levels of the observation group were significantly lower (P<0.05). Erxiaoji Zhike Oral Liquid combined with budesonide has a significant effect on children with bronchial asthma. The mechanism may be related to the regulation of serum IFN-γ, IL-4, TGF-β1 and NO levels. [ABSTRACT FROM AUTHOR]