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Objective: To compare the clinical effects of uterine fibroids treated with transvaginal and laparoscopic hysteromyoma. Methods:80 patients with uterine fibroids from February 2009 to February 2011 were treated, according to the random number table they were divided into transvaginal groups (40 cases) and laparoscopic group (40 cases). Two group of patients for surgical trauma, postoperative pain and postoperative morbidity rates were compared. Results: The operative time, blood loss, postoperative anal exhaust time, postoperative pain and postoperative morbidity rate of vaginal hysterectomy excision are better than laparoscopic myomectomy, the differences are statistical significant (P<0.05). Conclusions: On selecting the appropriate indications, vaginal hysterectomy excision and laparoscopic myomectomy are both safe and effective minimally invasive surgical clinic. But vaginal hysterectomy surgery is much better with the advantages of less trauma, lighter pain and postoperative pain surface without scars, etc. [ABSTRACT FROM AUTHOR]