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Oocyte quality is one of the key factors that affect the efficiency of human assisted reproductive technology (ART). Current clinical data and basic research results showed that a part of oocytes from ART were abnormal in spindle assembly, gene expression, organelle morphology and function, etc. Those abnormalities could lead to lower rate of embryo development and some long-term health risks of offspring. Thus, the identification of the most competent oocyte can optimize translation process and improve the outcome of ART. However, the lack of reliable and objective predictive marker for oocyte/embryo selection during IVF-ET greatly hindered the clinical application of this technology. This article reviewed the existing methods to evaluate the oocyte quality, providing us some basis and guidance for clinical practice. [ABSTRACT FROM AUTHOR]