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Objective: To explore the relationship among subjective well-being and depression-anxiety-stress and dispositional mindfulness in professional athletes, and the role of cognitive fusion and experiential avoidance and age in the relationship. Methods: Totally 423 professional athletes were selected and assessed with the Satisfaction with Life Scale (SWLS), Positive Affect Scale (PAS), Depression-Anxiety-Stress Scale (DASS-21), Five Facet Mindfulness Questionnaire (FFMQ), Cognitive Fusion Questionnaire (CFQ), and Acceptance and Action Questionnaire-Ⅱ (AAQ-Ⅱ). Results: After controlling for gender, the FFMQ scores were positively correlated with SWB scores (β=0.35), and negatively correlated with DASS-21 scores (β=-0.40). The scores of CFQ and AAQ-Ⅱ played a sequential mediating role in the relationship between FFMQ scores and the scores of SWB and DASS-21 (β=0.04, -0.12). Age moderated the relationship between the scores of FFMQ and SWB (β=-0.01).Conclusion: The subjective well-being and depression-anxiety-stress may be related to dispositional mindfulness in professional athletes, and age could moderate the relationship between subjective well-being and dispositional mindfulness. [ABSTRACT FROM AUTHOR]