Search

BACKGROUND: As a common clinical digestive disorder, irritable bowel syndrome becomes an advantageous disease of acupuncture treatment. However, the therapeutic mechanisms remain unclear. The methodological characteristics of omics coincide with the multi-target and multi-level characteristics of acupuncture, providing the possibility of revealing the principle of acupuncture in the treatment of the disease. OBJECTIVE: To investigate the pathogenesis of irritable bowel syndrome with diarrhea (IBS-D) and the effect of acupuncture at the combined points (selected based on etiologies and symptoms) on IBS-D based on proteomics. METHODS: Twelve 3-month-old male Sprague-Dawley rats were randomly divided into three groups: a control group, an IBS-D model group and an acupuncture group. The IBS-D rat models were prepared using the CAS method. After successful modeling, bilateral Zusanli points, bilateral Neiguan points and Guanyuan points were selected for acupuncture treatment in the acupuncture group, with a frequency of 120 times/minute, 1 minute of acupuncture every 4 minutes, and 15 minutes of needle retention, at an interval of 1 day every 6 days, for 28 days in total. Rats in the normal control group and the model group were not given any intervention. The pressure threshold of rat abdominal retraction reflex was measured to evaluate the visceral hypersensitivity of rats. Proteomics analysis was performed using the liquid chromatography-tandem mass spectrometry -based platform. MaxQuant software, Perseus software and DAVID, KOBAS, VENNY, STRING online tools were used for the bioinformatics analysis of proteomic data. Visualization analysis was done using Cytoscape 3.7.1 software. RESULTS AND CONCLUSION: There were 47 differentially expressed proteins between the IBS-D model and control groups. Function analysis of differentially expressed proteins revealed that the pathogenic mechanism of IBS-D was associated with abnormal energy metabolism, the imbalance of colon motor function and increased visceral sensitivity. Important proteins related to IBS-D pathogenesis included Atp5a1, Atp5c1, Idh3b, Atp2a3, Pdhb, Ppp1ca and Mapk3. Sixtyone differentially expressed proteins were identified between the acupuncture group and IBS-D model group. Acupuncture at the combined points reversed the up-regulation of nine differentially expressed proteins and the down-regulation of nine differentially expressed proteins. Bioinformatics analysis revealed that acupuncture at the combined points for IBS-D could function via multi-targets and multi-pathways, reverse the damage of energy metabolism caused by IBS-D, and play a role against oxidative stress and inflammation, thereby relieving pain and regulating the imbalance of intestinal function. Important proteins related to acupuncture effects included Atp5a1, Atp5c1, Pdhb, Sars, Uqcrc2, Prdx2, Prdx4, Ppp1ca, Manf and Tmsb4x3. All these findings preliminarily illustrate the potential molecular mechanisms of IBS-D and the effect of acupuncture at the combined points in the treatment of IBS-D at the protein level, which provide a basis for the clinical application of acupuncture at the combined points. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of short-term acupuncture on dysphagia in patients with cerebral- type Wilson's disease（WD). Methods Ninety patients with cerebral WD and swallowing dysfunction were randomly as⁃ signed to acupuncture（n=30), sham acupuncture（n=30), and control（n=30） groups. Patients in all groups received conventional drug treatment, while patients in the acupuncture group received additional acupuncture at Jingjin （EX- HN12), Yuye（EX-HN13), Renying（ST9), Lianquan（RN23), Lianquan lateral point, and Tiantu（RN22). Patients in the sham acupuncture group received shallow puncture beside the acupoints without needle manipulation. Treatment fre⁃ quency was once a day for 5 days a week over 2 weeks. Surface electromyography（sEMG）was collected using a Noraxon surface EMG tester, and data were processed with MR3. 14 software to record the median frequency（MF）of relevant mus⁃ cle groups. Swallowing function was evaluated using the Watian Water Drinking Test（WST）and the Standardized Swal⁃ lowing Assessment（SSA). Quality of life was assessed using the Swallowing Quality of Life（SWAL-QOL). Nutritional sta⁃ tus was evaluated by measuring serum albumin （Alb） using an immunoturbidimetric assay. Results After treatment, the MF of the submental and infrahyoid muscle groups in the acupuncture group was significantly higher than in the sham acupuncture and control groups（P<0. 05 or P<0. 01); the sham acupuncture group had higher MF than the control group （P<0. 05 or P<0. 01); there were no significant differences in the masseter or orbicularis oris muscle MF among the three groups（all P>0. 05). WST and SSA scores after treatment in all groups were lower than those before treatment, and those were lower in the acupuncture and sham acupuncture groups than in the control group（P<0. 05 or P<0. 01); there was no significant difference between the acupuncture and sham acupuncture groups（P>0. 05). The SWAL-QOL score and serum Alb levels after treatment in the acupuncture group were higher than those before treatment, which were higher than those in the sham acupuncture and control groups（all P<0. 01). There were no significant changes in the SWAL-QOL score or serum Alb levels in the sham acupuncture and control groups（all P>0. 05). Conclusion Short-term acupuncture signifi⁃ cantly improves the functions of submental and infrahyoid muscle groups in cerebral WD patients with dysphagia, and en⁃ hances quality of life and nutritional status by improving swallowing function. [ABSTRACT FROM AUTHOR]

Objective To explore the central analgesic mechanism of acupuncture at Guanyuan acupoint and Sanyinjiao acupoint in treatment of primary dysmenorrhea（PDM). Methods Twenty patients in the PDM group and 27 healthy control group were included. The resting-state functional magnetic resonance imaging（rs-fMRI） scans were performed on the 1st to 3st days of menstruation respectively. In the PDM group, acupuncture at Guanyuan acupoint and Sanyinjiao acupoint was performed continuously one week before the next menstrual period until menstruation began. Visual analogue scale（VAS） for pain, Cox menstrual symptom scale（CMSS), self-rating Anxiety Scale（SAS), and self-rating Depression Scale（SDS） were used to evaluate clinical symptoms. SPM and DPARSFA software based on Matlab platform were used for data preprocessing, regional homogeneity（ReHo） statistical parameters and brain function images, and the difference in ReHo values before and after acupuncture treatment was compared. Results The VAS, CMSS, SAS, and SDS scores decreased after acupuncture in comparison with those before treatment in patients of the PDM group（all P＜0. 01). After acupuncture, the ReHo values of left temporal pole and superior temporal gyrus, left precentral gyrus and postcentral gyrus increased significantly in PDM patients, while ReHo values decreased significantly in left middle temporal gyrus, bilateral precuneate lobe and left peri-talar fissure cortex. Compared with the healthy control group, ReHo increased in right dorsolateral superior frontal gyrus and right insular lobe after, left superior temporal gyrus and left precentral gyrus, while ReHo decreased in right thalamus, left middle temporal gyrus, bilateral anterior cingulate and lateral cingulate gyrus and medial superior frontal gyrus in PDM group. Conclusion Acupuncture at Guanyuan acupoint and Sanyinjiao acupoint in the treatment of PDM mainly locates in the pain and emotion conduction pathway and limbic system, and alleviates PDM pain by regulating the brain function of pain-related brain areas. [ABSTRACT FROM AUTHOR]

Background Long COVID is a common problem in the recovery period of coronavirus disease (COVID-19). The prevention and treatment of long COVID has become the focus of the medical fields of COVID-19. It is important to clarify the situation of long COVID in China and find out the follow-up research route, thus providing evidence-based evidence for clinical practice. Objective To explore the characteristics of long COVID in China, aiming to provide references for the follow-up research. Methods From January 2023 to August 2023, a self-made survey questionnaire was used to investigate the current situation of long COVID in China. The questionnaire included general information, such as gender and age, treatment expectations, symptoms and signs in acute and recovery period, etc. Results A total of 1 001 questionnaires were collected, including 901 people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and 585 (64.9%) people with long COVID. Binary Logistic regression analysis showed that female (OR=2.000, 95%CI=1.477-2.705, P

BACKGROUND: In the research on acupuncture treatment for lumbar disc herniation, most acupuncture treatments are performed under CT guidance or without guidance. The precise control of the target site and the effective acupuncture location are not clear. OBJECTIVE: To observe the clinical effects of acupuncture at Jiaji points under ultrasonic guidance in treating lumbar disc herniation. METHODS: A total of 70 cases of lumbar disc herniation, 36 males and 34 females aged 18-65 years old, were selected from Chinese PLA General Hospital and Third Affiliated Hospital of Beijing University of Chinese Medicine. They were divided into trial group and control group by random number table method, with 35 cases in each group. The control group received acupuncture at Jiaji points. The trial group received acupuncture at Jiaji points under ultrasonic guidance. The patients were treated once on the day of treatment and 4, 7 days after treatment. Visual analog scale score, Oswestry disability index, Japanese Orthopaedic Association score, and MOS 36-Item Short-Form Health Survey (SF-36) were evaluated before and after treatment. RESULTS AND CONCLUSION: (1) Compared with before treatment, the visual analog scale scores of both groups were decreased after treatment (P < 0.01). Compared with the control group, the visual analog scale scores of the trial group were decreased on days 2, 3, 6, 7 of treatment and 1, 2 weeks after the end of treatment (P < 0.05, P < 0.01). (2) Compared with before treatment, Oswestry disability index after treatment was decreased in both groups (P < 0.01). Compared with the control group, Oswestry disability index of the trial group was decreased from days 1 to 7 of treatment and 1, 2 weeks after treatment (P < 0.01). (3) Compared with before treatment, the Japanese Orthopaedic Association scores of both groups were increased after treatment (P < 0.01). Compared with the control group, the Japanese Orthopaedic Association scores of the trial group were increased on days 3, 7 of treatment and 1, 2 weeks after treatment (P < 0.05, P < 0.01). (4) Compared with before treatment, SF-36 scores in both groups were increased after treatment (P < 0.01). There was no significant difference in SF-36 scores between the two groups after treatment (P > 0.05). (5) These results show that acupuncture at Jiaji points has curative effect on lumbar disc herniation, and ultrasonic guidance could improve the clinical curative effect of acupuncture at Jiaji points for lumbar disc herniation. [ABSTRACT FROM AUTHOR]

BACKGROUND: Rheumatoid arthritis is a chronic autoimmune disease characterized by joint pain, swelling, and dysfunction. Acupuncture, as a traditional medical treatment, has proved its effectiveness and safety in many diseases. However, the efficacy of acupuncture in the treatment of rheumatoid arthritis remains controversial. Therefore, the purpose of this study is to evaluate and explore the effect of Tiaodu Tongmai acupuncture in the treatment of preclinical rheumatoid arthritis of different ages through the generalized estimating equation, and to provide a basis for the application of acupuncture in rheumatoid arthritis. OBJECTIVE: To investigate the effect of Tiaodu Tongmai acupuncture therapy on preclinical rheumatoid arthritis (pre-RA) patients at different ages based on generalized estimating equation. METHODS: A total of 123 patients with preclinical rheumatoid arthritis treated from January to September 2023 were selected as the study objects and divided into study group (n=64) and control group (n=59) according to different treatment methods. The study group was given Tiaodu Tongmai acupuncture treatment, and the control group was given acetaminophen tablets. The baseline balance was adjusted by propensity score matching method. The clinical efficacy and cytokine levels before and after treatment between the two groups were compared. The generalized estimating equation model was established to evaluate the efficacy of Tiaodu Tongmai acupuncture therapy on preclinical rheumatoid arthritis patients at different ages. RESULTS AND CONCLUSION: (1) After 0 days of treatment, there were significant differences in joint pain and C-reactive protein expression between study and control groups (P < 0.05). After 4 weeks of treatment, there were significant differences in visual analogue scale scores, joint pain, C-reactive protein and erythrocyte sedimentation rate between the two groups (P < 0.05). After 8 weeks of treatment, there were significant differences in visual analogue scale scores, C-reactive protein and erythrocyte sedimentation rate between the two groups (P < 0.05). After 12 weeks of treatment, there were significant differences in visual analogue scale scores, C-reactive protein and erythrocyte sedimentation rate between the two groups (P < 0.05). (2) The total effective rate of the study group was 93.75%, while that of the control group was 79.17%. The clinical efficacy of the study group was significantly better than that of the control group (P < 0.05). (3) There were significant differences in interleukin-6, interferon-γ, macrophage migration inhibitory factor, rheumatoid factor IgA, rheumatoid factor IgM, metallomatrix proteinase 3, metallomatrix proteinase 9, and anti-cyclic citrulline antibody in the study group before and after treatment (P < 0.05). The levels of interleukin-6, interferon-γ, rheumatoid factor IgA, rheumatoid factor IgM, metallomatrix proteinase 3, metallomatrix proteinase 9, and anti-cyclic citrulline antibody in the control group after treatment were significantly different from those before treatment (P < 0.05). There were significant differences in interleukin-6, interferon-γ, macrophage migration inhibitory factor, rheumatoid factor IgA, rheumatoid factor IgM, metallomatrix proteinase 3, and anti-cyclic citrulline antibody between the two groups after treatment (P < 0.05). (4) After 12 weeks of treatment, the comprehensive efficacy of patients of all ages in the study group was better than that of the control group (P < 0.05). After 8 weeks of treatment, the comprehensive efficacy of patients aged 23- 35, 36-50, and 51-60 years old in the study group was better than that of the control group (P < 0.05), and the comprehensive efficacy of patients aged 18- 22 years old was comparable between the two groups. After 4 weeks of treatment, the comprehensive efficacy of patients aged 36-50 and 51-60 years old in the study group was better than that of the control group (P < 0.05), and the comprehensive efficacy was comparable between the two groups of patients aged 18-22 and 23-35 years. Overall, Tiaodu Tongmai acupuncture therapy has advantages in treating preclinical rheumatoid arthritis patients aged 36-50 and 51- 60 years. [ABSTRACT FROM AUTHOR]

BACKGROUND: Vertigo is closely related to clinical neurological disorders. When neurons are damaged or dead, it may lead to abnormalities in the vestibular system and trigger vertigo symptoms. Therefore, it is necessary to explore and analyze the hotspots related to vertigo that are common in clinical neurology. OBJECTIVE: To analyze the vertigo-related histopathological changes in clinical neurology and the research hotspots worldwide using bibliometric methods. METHODS: The WanFang database and Web of Science core set database were searched by the first author to retrieve the research-related literature published from 2014-2023 on the treatment of common vertigo in clinical neurology. A bibliometric analysis of the number of publications, country/region, institution, keywords, co-cited literature, and highly cited literature was peformed using VOSviewer_1.6.19 software to summarize the research hotspots in this research field. RESULTS AND CONCLUSION: Web of Science core set database had the highest number of 174 publications in this field in 2022, and WanFang database had the highest number of 133 publications in this field in 2020. The top 3 countries with the highest number of publications are the United States, Germany, and China. The University of Munich, Germany is the international institution with the highest number of publications in this field, while Chengdu University of Traditional Chinese Medicine is the Chinese institution with the highest number of publications in this field. The results of keyword analysis showed that the research hotspot diseases in this field in China are mainly Meniere’s disease, cervical vertigo, senile vertigo, benign paroxysmal positional vertigo, isolated vertigo, and hypertensive vertigo, and the treatments include acupuncture, rehabilitation, medication (gastrodin, Banxia Baizhu Tianma Tang), and manipulative reduction. International research hotspot diseases in this field mainly include benign paroxysmal positional vertigo, vestibular disorders in new coronavirus cases, Meniere’s disease, vestibular schwannoma, acoustic neuromas, and vestibular migraines, etc., and the hotspot treatments are antivertiginous medications, antidepressant and anxiolytic treatments, and microsurgery. The results of literature co-citation analysis showed that for acute vestibular syndrome with persistent vertigo as the main symptom, three-step bedside ophthalmoscopy (HINTS: Head-Impact-Nystagmus-Strabismus Test) is more sensitive than early MRI in the diagnosis of combined strokes in patients with acute vestibular syndrome, which is the most peer-recognized method of detecting strokes in vestibular syndrome, whereas hormonal therapy is more effective to treat vestibular neuritis patients with paroxysmal vertigo as the main symptom. The results of highly cited literature analysis showed that, in the hot literature included in WanFang database in the past 10 years, acupuncture at Fengchi point and the acupuncture method of inducing resuscitation to improve posterior circulation ischemic vertigo have achieved certain results. The literature published in the past 3 years has indicated that Ginkgo biloba leaf extract+gastrodin, acupuncture+Banxia Baizhu Tang, betahistine+gastrodin, vestibular rehabilitation training+Epley Maneuver, all can improve the vertigo symptoms to different degrees. While there were no featured anti-vertigo drugs indicated in the literature in the Web of Science core set data in the recent 10 years, and most of them are based on traditional anti-vertigo drugs and microsurgery. However, there are a few case reports in the international literature in the last 3 years that found that COVID-19 infection may lead to vestibular neuritis and vertigo symptoms. The onset and progression of vertigo may be closely related to neuronal damage and regeneration. For example, viral infections, inflammatory stimuli, or other pathologic factors may lead to neuronal damage or death, thereby affecting the function of the vestibular system. Vertigo-related diagnosis and treatment standardization guidelines have been published both domestically and internationally. Currently, international guidelines recommend the combination of vestibular rehabilitation and physical rehabilitation for the treatment of vertigo, and Chinese guidelines recommend the combination of Chinese and Western medicine, reduction and acupuncture. However, the level of evidence is not very high, so a large number of large-sample, multicenter randomized controlled trials on anti-vertigo treatment are needed in the future. [ABSTRACT FROM AUTHOR]

BACKGROUND: Intervertebral disc degeneration is caused by damage and degeneration of the nucleus pulposus and annulus fibrosus tissues inside the intervertebral disc, resulting in structural and functional changes of the intervertebral disc. However, there is yet no effective drug treatment for intervertebral disc degeneration. OBJECTIVE: To investigate the inhibitory effect of syringin on intervertebral disc degeneration. METHODS: A total of 10 male Sprague-Dawley rats were selected, and the coccygeal intervertebral disc (Co4/Co5) of each rat was set as model group, Co5/Co6intervertebral disc as syringin group, and Co6/Co7 intervertebral disc as control group. The control group did not receive any treatment. In the model group and syringin group, a miniature puncture needle was used to puncture the annulus fibrosus to establish an intervertebral disc degeneration model. Immediately after modeling, 2. 5μL of normal saline and syringin solution (5μmol/L) were given in the model and syringin groups, respectively. Four weeks after injection, the samples were taken. The degree of intervertebral disc degeneration in rats was observed by hematoxylin-eosin and safranine O-fast green staining. The expressions of type II collagen, aggrecan and matrix metalloproteinases 3 and 13 in intervertebral disc tissue were analyzed by immunohistochemical staining. RESULTS AND CONCLUSION: Hematoxylin-eosin staining showed that in the model group, the height of intervertebral disc decreased, the cartilage endplate became thinner and cracked, the fibrous ring structure was disordered and cracked, and the nucleus pulposus disappeared;in the syringin group, the height of intervertebral disc was normal or slightly lower than that in the control group, the degree of cartilage endplate degeneration was lighter than that in the model group, the fiber circle permutation was relatively regular with no cracks, and the nucleus pulposus was partially shrunk. Safranine O-fast green staining showed that in the model group, the cartilage endplate of the intervertebral disc was defective and the calcified layer of cartilage became thinner, showing obvious degeneration. The structure and morphology of intervertebral disc cartilage endplate in the syringin group recovered to some extent. Immunohistochemical staining showed that, compared with the control group, the expressions of type II collagen and aggrecan in the intervertebral disc cartilage were decreased in the model group (P＜0. 000 1), while the expressions of matrix metalloproteinases 3 and 13 increased (P＜0. 000 1). Compared with the model group, the expressions of type II collagen and aggrecan in the intervertebral disc cartilage tissue were increased in the syringin group (P＜0. 001, P＜0. 000 1), while the expressions of matrix metalloproteinases 3 and 13 decreased (P＜0. 001, P＜0. 000 1). These results showed that syringin could improve the structure and function of intervertebral disc by inhibiting the expression of matrix metalloproteinases 3 and 13 and increasing the expression of type II collagen and aggrecan, thus preventing and slowing down the procession of intervertebral disc degeneration [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of Traditional Chinese Medicine (TCM) acupuncture combined with rehabilitation nursing on improving recovery of limb motor function and self-care ability of stroke patients with hemiplegia. Methods Totally 70 stroke patients with hemiplegia were randomly divided into the study group and control group, with 35 cases in each group. All patients received routine rehabilitation treatment, including vital sign monitoring, prevention and treatment of complications, medication guidance and rehabilitation training. Patients in the study group were given TCM acupuncture combined with rehabilitation nursing. The Fugl-Meyer Assessment (FMA) scale was used to evaluate the limb motor function, and Barthel Index (BI) of Activity of Daily Living scale was used to evaluate patients’ self-care ability. (P＜0. 05). Conclusion TCM acupuncture combined with rehabilitation nursing is effective to improve recovery of limb motor function, self-care ability and quality of life of stroke patients with hemiplegia. Results Scores of the FMA scale and BI were increased in both two groups after intervention, and scores of the FMA scale and BI in the study group were higher than those in the control group (目的 探讨运用中医针灸与康复护理干预改善脑卒中偏瘫患者肢体功能和生活自理能力的效果。方法 选取医院收治70例脑卒中偏瘫患者为研究对象, 随机分成研究组和对照组, 各35例。对照组患者接受常规康复理疗和护理, 包括生命体征监测、并发症防治、药物指导、康复训练等; 研究组在常规康复理疗和护理的基础上, 增加中医针灸和康复护理干预。采用Fugl-Meyer运动功能评分(FMA)评估患者躯体功能康复情况, 采用改良Barthel指数(BMI)评估患者日常生活活动能力。结果 干预后, 两组患者FMA和BMI评分均较干预前提高, 且研究组FMA和BMI评分高于对照组, 差异有统计学意义(P＜0. 05)。结论 中医针灸结合康复护理干预能有效改善脑卒中偏瘫患者临床症状, 促进其肢体功能康复, 提高日常自理能力, 从而改善患者生活质量。)

Given the increasing number of aging population in china, the rehabilitation nursing for stroke patients has been becoming the focus of attention in china. The Traditional Chinese Medicine acupuncture is proved to be an effective treatment of stroke and its sequelae. This paper reviewed studies on acupuncture rehabilitation nursing interventions for stroke patients in perspectives of cephalic acupuncture, body acupuncture and its combination with modern rehabilitation technologies, and provided reference for post-stroke rehabilitation practice. (随着人口老龄化趋势加重, 脑卒中患者的康复护理成为社会关注的重点。针刺治疗脑卒中及后遗症效果明确。本研究就头针、体针以及头体针联合现代康复在脑卒中康复干预中的应用现状进行综述, 旨在为促进脑卒中患者的功能康复提供参考。)

This paper summarize the nursing practice of facial neuritis in a patient with multiple myeloma during the interval between chemotherapy. In addition to facial care, rehabilitation training and emotion care, Traditional Chinese Medicine characteristic nursing techniques such as acupoint application and acupuncture were carried out to relieve the symptoms of facial paralysis and anxiety of the patient, and ensure the following chemotherapy. (本文总结1例多发性骨髓瘤患者化疗间歇期合并急性面神经炎的护理经验。在面部护理、康复训练、情志护理的基础上, 采用穴位贴敷、针灸疗法等中医特色护理措施, 有效改善患者面瘫症状, 缓解焦虑情绪, 确保后续化疗疗程的顺利进行。)

Objective To observe the clinical efficacy of Youshi acupuncture in the treatment of low back pain with kidney deficiency. Methods A total of 60 patients with kidney deficiency and low back pain were randomly divided into experimental group and control group, with 30 cases in each group. The experimental group was treated at Youshi (17:00-19:00,17:00-18:30). The control group was treated at a time other than Youshi (working hours other than 17:00-19:00). Selection of acupoints: Shenshu, Baihuanshu, Weizhong and Taixi four acupoints were selected, and the three acupoints of Huantiao, Yanglingquan and Dachangshu commonly used in clinic were selected. The course of treatment was once a day, 10 times as a course of treatment, two courses of treatment to observe the curative effect. Results The visual analogue scale (VAS) score of the two groups was eight before treatment and one after treatment in the experimental group. The median score of the control group was seven before treatment and two after treatment. After treatment, the experimental group was lower than the control group, the difference was statistically significant (P< 0.05). After treatment, the two groups were lower than those before treatment, differences being significant (P<0.05). There was no significant difference in the subjective symptoms, clinical signs and daily activities of the Japanese Orthopaedic Association (JOA) low back pain score between the two groups before treatment(P >0.05). After treatment, the experimental group was higher than the control group, and the difference was statistically significant(P<0.05). After treatment, the two groups were higher than those before treatment, and the difference was statistically significant (P<0.05). The cure rate of the experimental group (20.0%) was higher than that of the control group(0), and the difference was statistically significant (P=0.024). The effective rate of the experimental group(60.0%) was higher than that of the control group(13.3%), and the difference was statistically significant(X² = 14.067.P<0.001). Conclusion The effect of the experimental group in the treatment of kidney deficiency type low back pain is better than that of the control group. Youshi acupuncture in the treatment of kidney deficiency type low back pain is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

The eyes, ears, nose, and throat are essential vital sensory organs in the human body, contributing to our perception of the world and playing crucial roles in social interaction, emotional expression, and personal development. Nevertheless, due to changes in lifestyle patterns and the impact of the novel coronavirus in recent years, there has been a significant increase in conditions affecting these sensory organs, which has had a substantial impact on both individual health and social well-being. Traditional Chinese medicine’s meridian theory regards these organs as integral components with intricate interconnections. Acupuncture, a simple and safe therapeutic practice within traditional Chinese medicine, has demonstrated promising clinical effectiveness and extensive potential applications in this field. This article provides an overview of acupuncture’s current clinical applications for common disorders related to the eyes, ears, nose, and throat with the aim of exploring its potential for managing diseases in this area. [ABSTRACT FROM AUTHOR]

BACKGROUND: Nowadays, there are increasing reports on the digitization and visualization system of acupuncture points for adults in traditional Chinese medicine, and the digitization and visualization system of acupuncture points for children in traditional Chinese medicine and the simulation system of acupuncture manipulation for Mongolian medicine training have been reported. However, there are no reports on relevant systems for children in Mongolian medicine. OBJECTIVE: To develop a simulation system of acupuncture points for children in Mongolian medicine, in the hope that it can be used for clinical teaching, manipulation practice and research on acupuncture safety. METHODS: Based on the tomographic anatomical dataset of preschool boys, a three-dimensional (3D) digital virtual anatomical model of children with multiple internal organs and tissues was constructed by using PhotoShop.2021 and Digihuman Reconstruction System software. The relevant annotation information database of 27 acupoints such as Dinghui acupoint of Mongolian medicine was compiled by the Unity database language. The Mongolian gold needle and silver needle were selected to record the acupuncture point teaching video on the 3D printed head and neck resin model of children. In Unity3D software, children’s anatomical model, acupoint annotation information database and acupuncture operation video were integrated and coded, and a 3D digital children’s Mongolian acupuncture acupoint visualization system integrating simulation acupuncture training, clinical teaching and acupuncture safety research was successfully created. RESULTS AND CONCLUSION: This study was based on real children’s specimens. In order to reduce the error of two-dimensional segmentation, the manual layer-by-layer segmentation section image method was used to ensure the accuracy of the 3D model to the greatest extent. The Digihuman Reconstruction System was used to extract and save the individual segmentation data while maximizing the accuracy of the 3D model. PhotoShop.2021 software was used to complete the 3D reconstruction of the outer skin of the head and neck of children and the internal bony structure, cervical spinal cord, blood vessels and nerves, muscles and ligaments. After 3D reconstruction, the basic morphology of each independent structure and the integrity of the overall contour were verified in MeshLab software and the final fine adjustment and anatomical position confirmation were conducted using 3-matic research 13.0 software. The real anatomical morphology of the head and neck of preschool children was successfully simulated and restored. Unity3D software was used to integrate the 3D model of children, acupuncture operation video and acupoint annotation database, and the 3D digital Mongolian acupuncture acupoint visualization system for children was successfully constructed. Based on the real continuous fault ultra-thin dataset of preschool boys in China, China’s first 3D digitization and visualization system of acupuncture points in the head and neck of children in Mongolian medicine was developed. Compared with the previous acupuncture soft works, this system is more suitable for the anatomical morphological development characteristics of Asian children, and has a high value of application in the fields of research on the safety of acupuncture in Mongolian medicine, clinical teaching and acupuncture simulation training. [ABSTRACT FROM AUTHOR]

Objective To explore the functional improvement effect of acupuncture and moxibustion therapy of traditional Chinese medicine (mainly acupuncture on the three yang meridians of the hand, moxibustion on the governor vessel, and moxibustion through drugs) on cervical spondylosis of wind cold blocking collateral type. Methods 120 patients with wind cold obstruction type cervical spondylosis admitted to our hospital from July 2021 to July 2023 were randomly divided into two groups, with 60 cases in each group, using a random number table method. The control group was treated with conventional cervical traction, while the observation group was treated with traditional Chinese medicine acupuncture and moxibustion on the basis of the control group (mainly acupuncture at the hand Sanyang meridian+moxibustion at the governor's meridian+moxibustion through drugs). Compare the TCM syndrome scores, NDI, HO-1, LpPLA2, clinical efficacy, adverse reactions, hospitalization costs, and duration between two groups. Results After 4 weeks of treatment, the effective rate of disease in the observation group with wind cold obstructing cervical spondylosis (96.67%) was higher than that in the control group (83.33%), while the traditional Chinese medicine syndrome score, NDI score, HO-1, LpPLA2 in the observation group were lower than those in the control group (P < 0.05). No adverse reactions were observed in both groups. Conclusion Traditional Chinese medicine acupuncture and moxibustion therapy (mainly acupuncture of the three yang meridians of the hand, governor vessel moxibustion, and herbal penetration moxibustion) has significant clinical effect in the application of cervical spondylosis of wind cold blocking collateral type, which can effectively improve clinical symptoms and biochemical indicators, promote the rehabilitation of cervical function, and has high safety. [ABSTRACT FROM AUTHOR]

目的: 探究针灸是否通过调节脑源性神经营养因子(BDNF)及其下游酪氨酸激酶受体B(TrkB)对肠易激综合 征(IBS)大鼠的肠道屏障和内脏疼痛产生影响, 探究BDNF/TrkB信号通路作为针灸治疗新靶点的可能性。方法: 将60只SD大 鼠随机分为健康组、IBS组、针灸组、阳性对照组、针灸+TrkB激活组, 每组12只。建立IBS大鼠模型, 腹部撤回反射(AWR)检测 各组大鼠内脏疼痛;检测各组大鼠结肠TNF-α、IL-1β水平;免疫组化检测结肠黏膜胞质紧密黏连蛋白1(ZO-1)、闭合蛋白(occludin)表达水平;荧光定量PCR及Western blot检测各组大鼠结肠BDNF、TrkB mRNA及蛋白表达水平。结果: 与健康组相比, IBS组大鼠结肠黏膜出现破损, ZO-1、occludin表达显著降低, 大鼠AWR评分、粪便含水量、TNF-α、IL-1β含量、结肠BDNF、 TrkB mRNA及BDNF蛋白表达量、TrkB磷酸化程度显著升高(P<0.05);与IBS组相比, 针灸组、阳性对照组大鼠结肠黏膜逐渐 恢复, ZO-1、occludin表达显著升高, 大鼠AWR评分、粪便含水量、TNF-α、IL-1β含量、结肠BDNF、TrkB mRNA及BDNF蛋白表 达量、TrkB磷酸化程度显著降低(P<0.05);与针灸组相比, 针灸+TrkB激活组大鼠结肠黏膜仍有病变, ZO-1、occludin表达显著 降低, 大鼠AWR评分、粪便含水量、TNF-α、IL-1β含量、结肠BDNF、TrkB mRNA及BDNF蛋白表达量、TrkB磷酸化程度显著升 高(P<0.05)。结论: 针灸可通过调控BDNF/TrkB通路, 抑制相关蛋白表达, 改善肠道屏障功能, 减轻内脏疼痛及炎症反应, 缓解 IBS. Objective: To explore whether acupuncture can affect intestinal barrier and visceral pain of rats with irritable bowel syndrome (IBS) by regulating brain-derived neurotrophic factor (BDNF) and its downstream tyrosine kinase receptor B (TrkB), and to explore the possibility of BDNF/TrkB signaling pathway as a new target for acupuncture treatment. Methods: Sixty SD rats were randomly grouped into healthy group, IBS group, acupuncture group, positive control group and acupuncture+TrkB activation group, with 12 rats in each group. An IBS rat model was established, abdominal withdrawal reflex (AWR) was used to detect visceral pain of rats in each group; levels of TNF-α and IL-1β in colon of rats in each group were measured; expression levels of colonic mucosal cytoplasmic Claudin 1 (ZO-1) and occludin were measured with immunohistochemistry; expression levels of BDNF and TrkB mRNA and protein in colon of rats in each group were measured with fluorescence quantitative PCR and Western blot. Results: Compared with healthy group, colonic mucosa of rats in IBS group was damaged, expressions of ZO-1 and occludin were significantly reduced, AWR score, fecal water content, TNF-α and IL-1β contents, colonic BDNF, TrkB mRNA and BDNF protein expressions, and TrkB phosphorylation were significantly increased (P<0.05); compared with IBS group, colon mucosa of acupuncture group and positive control group gradually recovered, expressions of ZO-1 and occludin were significantly increased, AWR score, fecal water content, TNF-α and IL-1β contents, colonic BDNF, TrkB mRNA and BDNF protein expressions, and TrkB phosphorylation were significantly reduced (P<0.05); compared with acupuncture group, colonic mucosa of rats in acupuncture+TrkB activation group still had lesions, expressions of ZO-1 and occludin were significantly reduced, AWR score, fecal water content, TNF-α and IL-1β contents, colonic BDNF, TrkB mRNA and BDNF protein expressions, and TrkB phosphorylation were significantly increased (P<0.05). Conclusion: Acupuncture can regulate BDNF/TrkB pathway, inhibit expression of related proteins, improve intestinal barrier function, reduce visceral pain, inflammation and relieve IBS. [ABSTRACT FROM AUTHOR]

To observe the rehabilitation effect of acupuncture combined with joint loosening manipulation on patients with ankle fracture after operation and its effect on bone metabolism indexes and serum interleukin (IL) -1β, IL-8 and matrix metalloproteinase (MMP) -13. 138 patients with ankle fractures who were treated in the Third Affiliated Hospital of Southern Medical University from March 2020 to March 2023 were selected. Patients were divided into control group (receiving routine rehabilitation training combine with joint loosening manipulation, n=69) and study group (receiving acupuncture treatment on the basis of control group, n=69) according to the random number table method. The changes of visual analogue scale (VAS), American Orthopaedic Foot and Ankle Society (AOFAS) score, ankle dorsiflexion and plantar flexion activity, serum IL-1β, IL-8, MMP-13 and bone metabolism indexes [osteocalcin (BGP), bone alkaline phosphatase (BALP), β-collagen degradation products (β-CTX)] were compared between two groups. 1 month after treatment, the VAS score in study group was lower than that in control group, and the AOFAS score was higher than that in control group (P<0.05). 1 month after treatment, the activity of dorsal extension and plantar flexion in study group were higher than those in control group (P<0.05). 1 month after treatment, the levels of IL-1β, IL-8 and MMP-13 in study group were lower than those in control group (P<0.05). 1 month after treatment, β-CTX in study group was lower than that in control group, BGP and BALP were higher than those in control group (P<0.05). The application of acupuncture combine with joint loosening manipulation on patients with ankle fracture after operation, which can effectively reduce the level of inflammatory factors and the degree of pain, and promote the improvement of ankle function and bone metabolism. [ABSTRACT FROM AUTHOR]

Objective: To observe the effect of sour jujube kernel decoction combined with lily dihuang decoction plus minus combined with acupuncture on sleep quality and serum neurotransmitter levels in patients with yin deficiency insomnia after stroke.Methods: The selected cases were all from patients with insomnia after stroke admitted to our hospital during March 2018 to February2023, a total of 126 cases. According to the random number table method, the patients were divided into control group (conventional Western medicine treatment + acupuncture treatment, 63 cases) and observation group (63 cases received plus and minus treatment on the basis of sour jujube kernel soup and lily dihuang decoction, 63 cases) . The efficacy, TCM syndrome scores, and scale scores [Pittsburgh Sleep Quality Index Scale (PSQI), Sleep Status Self-rating Scale (SRSS) ], and serum neurotransmitters [serotonin (5-HT) and dopamine (DA) were compared between the two groups. Results: The total clinical effective rate of the observation group was higher than that of the control group, which showed statistical difference (P＜0.05) . After the treatment, the scores of the two groups were lower than those in the control group, which showed statistical difference (P＜0.05) . After treatment, PSQI score and SRSS score decreased in the two groups, and the observation group was lower than that in the control group, which showed statistical difference (P＜0.05) . After the treatment of the two groups, DA decreased and 5-HT increased, and the improvement in the observation group was greater than that in the control group, which showed statistical difference (P＜0.05) . Conclusion: The combination of sour jujube kernel decoction and lily dihuang decoction plus minus combined with acupuncture in the treatment of yin deficiency and fire type insomnia after stroke can effectively improve insomnia symptoms and regulate serum 5-HT and DA levels. [ABSTRACT FROM AUTHOR]

Objective: To observe the clinical effect of acupuncture combined with occupational therapy on children with autism spectrum disorder (ASD). Method: Seventy-two children aged 3—6 with ASD admitted to our hospital from January 2021 to December 2022, were randomly divided into two groups (control group and observation group) by simple number table method, with 36 cases in each group.The control group was treated with occupational therapy, and the observation group was treated with acupuncture on the basis of the control group. Both groups were treated continuously for 12 weeks. To compare the clinical effects of the two groups. The Gesell developmental scale (GDS), the autistic child behavior scale (ABC), the infantile and junior high school social living ability scale(S-M)and the psychoeducational scale for autistic children(PEP-3)were evaluated before and after treatment. And the side effects of acupuncture were analyzed. Result: The total response rate of the observation group was 83.33%, which was significantly improved compared with the total response rate of the control group of 61.11% in the study (P<0.05).After treatment, the total score of Gesell in the two groups, adaptive behavior, gross motion, fine movement, language and personalsocial, were improved compared with those before treatment, and the effect of observation group was significantly better than that of the control group, with statistically significant difference(P<0.05). In both groups, ABC communication, self-care factor score and total score were lower compared with those before treatment, and the effect of the observation group was better than that of the treatment group (P<0.05). The S-M score of the two groups was higher than before treatment, and the effect of the observation group was better than that of the control group (P<0.05). The scores of self- care and adaptive behavior of PEP-3 in both groups were significantly improved, and the improvement was more obvious in the observation group (P<0.05). The side effects of acupuncture were seldom in the observation group. Conclusion: Acupuncture combined with occupational therapy can effectively improve the developmental level of children with autism, improve their social life ability, and benefit the prognosis of children with autism. [ABSTRACT FROM AUTHOR]

Objective To explore the antidepressant effects of acupuncture at Buihui and Zusanli acupoints on mice with chronic unpredictable mild stress (CUMS)-induced depressive-like behavior and its association with changes in gut microbiota, Methods Sixty mice were randomly divided into four groups: control group (Ctrl). control acupuncture group (Ctrl + AP). CUMS group, and CUMS acupuncture group (CUMS AP). The CUMS and CUMS AP groups underwent 6-week CUMS treatment. During the last three weeks of CUMS, mice in the Ctrl AP and CUMS AP groups received 20 minutes of acupuncture at Baihui and Zusanli acupoints daily. Sucrose preference test and tail suspension test were used to assess the depressive-like behavior in mice. After the behavioral tests, fecal samples were collected from the mice, and the gut microbiota composition was analyzed using 165 rRNA gene sequencing Results Acupuncture alone had no effect on sucrose preference or tail suspension test results in mice (P>0.05), CUMS induced depressive-like behavior in mice, as evidenced by decreased sucrose preference (P<0.001) and increased immobility time in the tail suspension test (P-0,003). The CUMS AP group showed increased sucrose preference (P-0,035) and decreased immobility time in the tail suspension test (P-0.045) compared to the CUMS group. Acupuncture and CUMS did not alter the richness of gut microbiota in mice (P> 0.05), but they caused significant changes in gut microbiota composition (P-0.002), CUMS increased the abundance of six bacterial genera, including Patulibacter and decreased the abundance of 25 bacterial genera. including Faecalibacterium (P<0.05). The CUMS AP group showed increased abundance of 10 bacterial genera including Faecalibacterium, and decreased abundance of four bacterial genera, including Patulibacter, compared to the CUMS group (P0.05). Each group of mice had specific gut microbiota. The CUMS group showed significant enrichment of gene functions related to retinol metabolism, ubiquitin system. N-glycan biosynthesis, steroid hormone biosynthesis apoptosis, and thermogenesis compared to the control group (P<0.05). while acupuncture reduced the enrichment of these gene functions in the CUMS AP mice (P<0.05). Conclusion Acupuncture at Baihui and Zusanli acupoints has antidepressant effects and can partially restore the depression-induced dysbiosis of gut microbiota. Acupuncture at Baihui and Zusanli acupoints may exert antidepressant effects by influencing gut microbiota composition and metabolism functions of retinol ubiquitin N-glycan, and steroids. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diabetic gastroparesis is a common complication in diabetic patients. It is manifested as recurrent nausea, vomiting, early saturation and abdominal fullness. The main pathophysiology is a condition that slows down the emptying of the stomach. In recent years, the external treatment of Traditional Chinese Medicine in the treatment of diabetic gastroparesis has been widely used in clinical practice, which can improve the clinical symptoms of patients. By searching the relevant literature, this paper briefly listed external treatment of Traditional Chinese Medicine, and looked forward to the future development direction of new nursing technology. (糖尿病胃轻瘫是糖尿病常见并发症之一, 表现为反复发作恶心、呕吐、早饱和上腹饱胀, 主要病理生理是胃排空延缓。近年来中医外治法治疗糖尿病胃轻瘫在临床实践中得到广泛应用, 可有效改善患者临床症状。本文通过检索相关文献, 简要列举糖尿病胃轻瘫中医外治疗法, 旨在为今后糖尿病并发症护理研究提供参考。)

Background Traditional Chinese acupuncture has been widely applied for the treatment of knee osteoarthritis (KOA) with outstanding efficacy. However, recognized and unified outcome indicators remain to be absent, which impedes the translation of research into high-quality clinical evidence. Therefore, the establishment of core outcome indicators for acupuncture in KOA is conducive to enhance the scientific rigor, rationality, and feasibility of clinical research programs in traditional Chinese medicine (TCM) , provide higher quality evidence-based basis for clinical research. Objective To analyze the current status of the application of outcome indicators in randomized controlled trials (RCTs) of acupuncture for KOA, so as to provide a basis for the assessment method of clinical efficacy. Methods PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang, VIP and SinoMed were searched for clinical RCTs of acupuncture in the treatment of KOA from 2003 to 2022. Two researchers screened and extracted the characteristics of literature. The indicator domain, measurement tools and the time point of measurement of RCTs of acupuncture for KOA were analyzed. Results A total of 131 papers were included, with a sample size of 22 726 cases and 89 outcome indicators, which were classified into 40 (44.9%) items for symptoms and signs, 22 (24.7%) items for physical and chemical examinations, 5 (5.6%) items for quality of life, 5 (5.6%) items for psychological state, 3 (3.4%) items for satisfaction evaluation, 2 (2.2%) items for safety indicators, and 12 (13.5%) items for other indicators. Among the 131 articles, 23 measurement time points were included in the 131 articles, ranging from 1 hour to 3 years after treatment, 106 (80.9%) articles used "clinical efficacy" as the outcome indicator, 23 (17.6%) articles used safety evaluation and adverse event reports. Conclusion There are some problems in the use of outcome indicators in the RCTs of acupuncture for KOA, such as large variation in the use of outcome indicators, confounding of primary and secondary indicators, abuse of index combination, irregular use of composite indexes, inadequate safety evaluation, irregular measurement time points, insufficient evaluation of long-term prognosis, and failing to reflect the characteristics of TCM intervention of acupuncture. Future research should combine treatment based on syndrome differentiation characteristics of TCM, to evaluate the efficacy of acupuncture in the treatment of KOA by using scientific and reasonable outcome indicators. It is urgent to establish the core indicators set of TCM in the treatment of KOA, and to construct a standardized and recognized COS-TCM.

Insomnia is the most common sleep disorder affecting millions of people worldwide. This paper summarized the Tradition Chinese Medicine nursing management of a patient with insomnia treated by auricular acupoint sticking-pressing therapy. Based on the nursing assessment and syndrome differentiation, Traditional Chinese Medicine nursing techniques such as auricular acupoint sticking-pressing therapy, head massage, acupuncture and emotional nursing were carried out to regulate patient's physiological functions and improve the sleep quality. (失眠已经成为全球范围内影响人群健康的常见疾病之一。本文总结1例耳穴贴压治疗失眠患者的中医护理经验。根据护理评估和辨证分型, 采取耳穴贴压、头部按摩、针灸、情志护理等中医护理干预, 调节患者生理功能, 进而有效改善患者睡眠质量。)

This article summarized the postoperative nursing of integrated traditional Chinese and Western medicine for an elderly patient undergoing surgery for thyroid cancer. Comprehensive nursing interventions such as basic nursing, acupuncture massage, dietary nursing, exercise guidance and psychological care were carried out. A comprehensive nursing plan of integrated traditional Chinese and Western medicine had been made to relieve the negative emotion and pain of the patient, and improve the sleep quality and quality of life during rehabilitation. (本文总结1例老年甲状腺癌患者术后中西医结合护理经验。根据患者术后症状, 完善基础护理, 中西医联合用药, 并采用针灸按摩、饮食调护、运动指导、心理干预等护理方法, 内外结合, 提升患者治疗信心, 缓解其负性情绪, 减轻疼痛, 改善睡眠质量, 提高患者的生活质量。)

Objective To observe the effect of acupuncture on the Akt/NF-KB signaling pathway in aging rats, and to explore the possible mechanism of acupuncture on the Pi Shu point to improve skeletal muscle atrophy to prevent and treat low back pain. Methods 32 male SD rats were randomly divided into blank group, model group, acupuncture group and positive drug group, 8 rats in each group. The rats in the blank group were injected subcutaneously with 0.9% saline [300 mg/(kg.d)] on the back of the collar daily, and the rats in the remaining three groups were injected subcutaneously with an equal amount of D-galactose on the back of the collar daily for 12 weeks. From the 9th week, the acupuncture group was treated with acupuncture on both sides of the Pi Shu, while the positive drug group was treated with mixed amino acid gavage for 4 weeks. The skeletal muscle tissue morphology was observed by HE staining, the apoptosis of skeletal muscle cells was detected by TdT-mediated dUTP Nick-End Labeling (TUNEL), the release of TNF-α, IL-1ẞ and IL-6 was detected by Elisa, and the protein expression levels of Akt, p-Akt, NF-кВ and P-NF-KB were detected by Western Blot. Results Compared with the blank group, the skeletal muscle cell gap in the modelgroup became wider, some myocytes were rounded, the number of myocyte apoptosis was high, and the levels of inflammatory factors IL-1B, IL-6 and TNF-α were significantly increased (P < 0.001, P < 0.01 and P < 0.05 ), and the protein expression levels of p-Akt, NF-kB and p-NF-KB were increased (P < 0.001) ; Compared with the model group, the muscle gap in the acupuncture and positive drug groud was narrower, myocytes were more closely arranged, the number of myocyte apoptosis was reduced, the levels of inflammatory factors IL-1B, IL-6andTNF-α decreased ( P < 0, P < 0.01 and P < 0.05 ), and the expression levels of p-Akt, NF-KB and P-NF-KB were down-regulated (P < 0.001) . Conclusion Acupuncture at Pi Shu can improve D-galactose-induced skeletal muscle aging and reduce the inflammatory response and apoptosis of skeletal muscle cells by inhibiting the Akt/NF-kB signaling pathway, which may be one of the potential mechanisms of action of acupuncture at Pi Shu point for the treatment of low back pain. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Wool Textile Journal is the property of National Wool Textile Science & Technology Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the clinical effects of Tiaojing Zhuyun mixture combined with regulating menstration and promoting pregnancy by thirteen acupuncture in the treatment of Declining Ovarian Function (DOR) combined with follicular dysplasia infertility. Methods From January 1, 2022 to January 1, 2023, 60 cases of infertility patients with DOR follicular dysplasia were treated in our hospital, and the above cases were randomly divided into experimental group : Tiaojing Zhuyun mixture+ regulating menstration and promoting pregnancy by thirteen acupuncture + Clomiphene group ; Control group : Clomiphene group, 30 cases each. The improvement of FSH, maximum follicle size and ovulation, uterine artery blood flow index, endometrial thickness and pregnancy were observed after treatment. Results The improvement of follicle stimulating hormone, maximum follicle size, endometrial thickness and uterine artery blood flow indexes in Tiaojing Zhuyun mixture+ regulating menstration and promoting pregnancy by thirteen acupuncture + Clomiphene group were better than clomiphene group. The difference between groups was statistically significant (P < 0.05). The ovulation rate was 66.7% and the pregnancy rate was 40%. The ovulation rate was 40% higher than the control group, and the pregnancy rate was 20%. The difference between groups was statistically significant (P < 0.05). Conclusion In the patients with DOR follicular dysplasia infertility, Tiaojing Zhuyun mixture combined with regulating menstration and promoting pregnancy by thirteen acupuncture can improve the level of follicle stimulating hormone, promote follicular maturation and ovulation, reduce the resistance of uterine artery blood flow, increase the thickness of endometrial, promote pregnancy, and have fewer adverse reactions. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical effect of Yangming meridian acupuncture combined with acupuncture push based on the theory of "treating flaccence and taking Yangming" in the treatment of Guillain-Barre syndrome. Methods 52 cases of patients with conventional rehabilitation combined with Yangming meridian acupuncture combined with acupuncture based on the theory of "treating potence and taking Yangming alone" were taken as the study group and 52 cases of patients with conventional rehabilitation alone as the control group. Limb muscle strength score, clinical efficacy, limb sensory function, limb motor function, upper limb median nerve electrophysiology and daily living ability were compared between the two groups. Results After treatment, muscle strength scores of proximal lower extremity, distal lower extremity, proximal upper extremity, distal upper extremity, median sensory nerve action potential (SNAP), motor conduction velocity (MCV), sensory conduction velocity (SCV) and modified Barthel index (MBI) were increased in 2 groups (P < 0.05). The study group was more obvious (P < 0.05). The total effective rate of the study group (86.54%) was higher than control group (69.23%) (P < 0.05). After treatment, the sensory function and motor function of limbs in 2 groups were better than before treatment (P < 0.05), especially in the study group (P < 0.05). After treatment, the distal motor latency (DML) of upper limb median nerve was decreased in 2 groups (P < 0.05), and more significantly in the study group (P < 0.05). Conclusion Yangming meridian acupuncture combined with acupuncture pushing based on the theory of "treating impotence and taking Yangming" is effective in the treatment of Guillain-Barre syndrome, which can improve the muscle strength, sensation and motor function of limbs, and regulate nerve electrophysiology. [ABSTRACT FROM AUTHOR]

The symbiotic relationship between humanities and technology constitutes the two pillars of the modern acupuncture academic system. However, in the process of disciplinary technological development, the humanistic aspect of acupuncture has not received deserved attention. Against the backdrop of interdisciplinary integration in scientific and educational development, acupuncture as a field needs to reexamine its own humanistic attributes. Building upon the fruitful achievements of previous scholars in humanistic research, it is essential to continue and expand the research of acupuncture humanities. This article reviews the current accomplishments in acupuncture humanistic research, highlighting the necessity of such research from three perspectives: the humanistic background of traditional Chinese medicine, the need for and inevitability of acupuncture discipline development, and the significance deficit faced by acupuncture research. The article puts forth four research directions: acupuncture literature and theoretical studies, acupuncture history research, acupuncture sociocultural studies, and acupuncture digital humanities research. Additionally, it proposes three fundamental method for conducting acupuncture humanistic research, namely, reading, interviewing, and practical application. Acupuncture and the humanities are, in fact, two sides of the same coin, both driven by the pursuit of truth. [ABSTRACT FROM AUTHOR]

In recent years, there have been advances in the fundamental research of acupuncture, yet the growing disconnect between this research and clinical practice has become increasingly evident. This paper revolves around the establishment of the discipline of Acupuncture Systems Engineering and explores the paradigm shift in acupuncture research from being science-driven to becoming technology-driven, with the aim of reshaping the innovative development path of acupuncture. Acupuncture Systems Engineering aims to investigate acupuncture techniques and their applications, while also seeking to establish research models and method that align with these pursuits, thereby providing new technological means and pathways for the study of acupuncture effects and achieving clinical translation. Under the guidance of Acupuncture Systems Engineering, acupuncture is no longer merely a traditional medical approach but has evolved into a multidisciplinary field of innovative traditional Chinese medicine, incorporating engineering, biology, information technology, artificial intelligence, and more. Through technology-driven research and application, Acupuncture Systems Engineering brings a revitalized and promising future to the field of acupuncture. [ABSTRACT FROM AUTHOR]

The initial step taken by the author involves an analysis of the merits and demerits associated with the theoretical paradigm of traditional acupuncture and moxibustion, specifically referred to as the macro and humanistic paradigm. By adopting a historical materialism and dialectical perspective, the author elucidates how the theoretical paradigm of traditional acupuncture and moxibustion is constrained by historical and technological circumstances. The proposition suggests that in response to the evolving landscape of science and technology across temporal and spatial dimensions, there is a need to shift and augment the traditional acupuncture and moxibustion paradigm. Specifically, this entails transitioning towards the micro and natural science paradigm. The subsequent analysis focused on the issues present within the current paradigm of acupuncture and moxibustion clinical research. It was posited that while the initial objective is to validate the clinical efficacy of acupuncture and moxibustion, the ultimate aim is to establish the instructive significance of traditional acupuncture and moxibustion theory. Moreover, the absence of novel theories and principles capable of guiding the modern scientific innovation in acupuncture and moxibustion clinical practice was identified. Finally, this paper presents the issues and initial concepts that warrant consideration in future clinical research on acupuncture and moxibustion within the context of a paradigm shift. Specifically, emphasis should be placed on investigating the theory and principles of acupuncture and moxibustion in light of the contemporary scientific understanding of human tissue structure and function. For instance, within the theoretical paradigm of local diagnosis and treatment, it is imperative to direct our attention towards the distinctive attributes and principles governing acupuncture therapy at various tissue levels on the external surface of the body. Similarly, within the remote and holistic diagnosis and treatment paradigm, it is crucial to thoroughly examine the instructive implications and pertinent characteristic principles associated with the neural network, fiber network, and vascular network in the context of clinical acupuncture and moxibustion. [ABSTRACT FROM AUTHOR]

Objective We aimed to explore the mechanism of action of cervical transverse process tip acupuncture in a rat model of posterior circulation ischemic vertigo (PCIV) based on the G protein-coupled receptor (Mas)/protein kinase A(PKA)/cyclophosphoadenosine effector binding protein (CREB) pathway. Methods According to the random number table method, 32 male SD rats were divided into the sham operation group (n=8), the model group (n=8), the nimodipine group (n=8), and the electroacupuncture group (n=8). In all groups except for the sham operation group, the PCIV model was established by ligating the right common carotid artery (CCA) and the right subclavian artery (SCA). In the sham operation group, only the right CCA and the right SCA were removed and sutured directly without ligation. The nimodipine group was given intragastric administration of nimodipine suspension (12 mg/kg), and the electroacupuncture group selected C2, C4, and C6 transverse process tip for acupuncture, and performed electroacup uncture treatment on both sides of C2 and C6, 20 minutes each time. There was no intervention in the sham operation group and the model group. The intervention was given once a day for 14 days. Cerebral blood flow, the decrease decline rate of cerebral blood flow, and the step-down avoidance time were recorded in each group. Apoptosis of neurons in the vestibular nucleus of the right brainstem was observed by TUNEL staining, and the protein expression levels of Mas, PKA-Ca, CREB, p-CREB, Bcl-2, and Bax in the vestibular nucleus of the right brainstem were determined by Western blotting. Results Before intervention, compared with the sham operation group, cerebral blood flow in the right vestibular nucleus was decreased and decline rate of cerebral blood flow in the right vestibular nucleus was increased in the remaining three groups (P<0.05), which suggested that the model was successfully established. After intervention, compared with the sham operation group, the model group showed lower cerebral blood flow in the right vestibular nucleus, larger decline rate of cerebral blood flow in the right vestibular nucleus, apoptosis rate in the vestibular nucleus of the right brainstem and protein expression level of Bax increased, and reduced protein expression levels of Bcl-2, Mas, PKA-Ca, and p-CREB/CREB (P<0.05). Compared with the model group, the electroacupuncture group and the nimodipine group showed increased cerebral blood flow in the right vestibular nucleus, a smaller decline rate of cerebral blood flow in the right vestibular nucleus, a shorter step-down avoidance time, a decrease in apoptosis rate in the vestibular nucleus of the right brainstem, decreased protein expression level of Bax, and increased protein expression levels of Bcl-2, Mas, PKA-Ca, and p-CREB/CREB (P<0.05). Compared with the nimodipine group, the electroacupuncture group had increased cerebral blood flow in the right vestibular nucleus, a smaller decline rate of cerebral blood flow in the right vestibular nucleus, a shorter step-down avoidance time, a decrease in apoptosis rate in the vestibular nucleus of the right brainstem, decreased protein expression level of Bax, and increased protein expression levels of Bcl-2, Mas, PKA-Ca, and p-CREB/CREB (P<0.05). Conclusion Cervical transverse process tip acupuncture can effectively inhibit apoptosis in the vestibular nucleus in rats with PCIV. Its mechanism may be related to improving cerebral blood flow of the vestibular nucleus and activation of the Mas/PKA/CREB signaling pathway, followed by the modulation of the levels of relevant proteins to inhibit apoptosis in the vestibular nucleus. [ABSTRACT FROM AUTHOR]

Education paradigm is a relatively stable action structure of education and training and its practical effect. The construction of a modern acupuncture and moxibustion education paradigm is a complicated historical process, which not only follows the internal logic of the academic development of acupuncture and moxibustion, but is also influenced by the development of modern education paradigm and medical and health services. With the establishment of modern acupuncture and moxibustion discipline, marked by Science of Acupuncture and Moxibustion written by the Teaching and Research Group of Acupuncture and Moxibustion Discipline of Jiangsu University of Traditional Chinese Medicine in 1957, the education and training model of acupuncture and moxibustion specialized talents in modern traditional Chinese medicine higher education is gradually formed, and solidified into college professional education model in the 1980s. Deconstructing the problems existing in the contemporary education paradigm of acupuncture and moxibustion mainly include the contradictions and problems between connotation and structure, formation and development, discipline and specialty, and level type and function. The transformation of the modern acupuncture and moxibustion education paradigm can be promoted by studying industry demands, revising training objective, defining discipline connotation, adjusting teaching content, learning from advanced concepts, and changing teaching modes. [ABSTRACT FROM AUTHOR]

Objective: To discover the effects of "Tiaoshenchangzhi" acupuncture on 5-HT4R and CaM-myosin in the colon tissue of rats with Parkinson's disease with constipation, and to examine their possible mechanisms of action. light link protein kinase (MLCK) signaling pathway in the colon tissue of rats with Parkinson's disease with restriction, and to explore their possible mechanisms of action. Methods: 60 rats were classified into the blank group, the sham operation group, the modelling group, the western medicine group, the regular acupuncture group and the "Tiaoshenchangzhi" acupuncture group using a casual number table, with 10 rats in each group. The rat model of Parkinson's disease(PD) with constipation was made by subcutaneous injection of rotenone into the neck and back of model group, routine acupuncture group and Tiaoshenchangzhi acupuncture group, and detected by APO induction. In the conventional acupuncture group, Tianshu, Zusanli, Shangjuxu and dance tremor control areas were selected and electroacupuncture was performed with continuous wave frequency of 15Hz and stimulation intensity of 2 mA. The needles were kept for 30 minutes, once a day, for consecutive 4 weeks. Tiaoshenchangzhi acupuncture group: Professor Wang Shun's "TiaoshenChangzhi" thirty-nine needle method was selected, Baihui penetrating the Taiyang, Zhongwuan, Qihai, Zusanli and Taichong. Soil continuous wave was used, with the frequency of head needle 45Hz, abdominal needle 30Hz and limb needle 15Hz(To reflect the quantitative stimulation of the weight of the head needle, the weight of the abdomen needle and the light of the limbs needle of The 369 acupuncture method of Tiaoshenchangzhi) > the stimulation intensity was about 2mA, and the needle was left for 30 min, once a day, for consecutive 4 weeks; The western medicine group received metopar and mosapride daily gavage for 4 weeks. Model group and sham operation group: gavage of 2 mL normal saline daily for 4 consecutive weeks; Blank groups are not processed. Western blot was used to detect the expression and content of 5-HT4R, CaM and MLCK protein in the proximal colon tissues of each group. Results: Compared with the blank group, the expression of 5-HT4R, CaM and MLCK protein in the proximal colon tissue of model group were significantly decreased(P<0.01). Compared with the model group, the expression of 5-HT4R, CaM and MLCK protein in the proximal colon tissue of three treatment groups (Western medicine group, routine acupuncture group and Tiaoshenchangzhi acupuncture group)were significantly decreased Elevated(P<0.01). Compared with conventional acupuncture group, the expression of 5-HT4R, CaM and MLCK protein in Tiaoshenchangzhi group was significantly increased(P<0.05). Conclusion: Acupuncture can ameliorate the symptoms of constipation in the rat model of PD with constraints, and the "Tiaoshenchangzhi"acupuncture group was better than the conventional acupuncture group. The mechanism of action may be realized by adjusting the 5-HT4R protein expression and activating the CaM-MLCK signaling pathway in the rat colon tissue. [ABSTRACT FROM AUTHOR]

Objective: To explore the therapeutic effect of GubenJiannao Anshen prescription combined with acupuncture on chronic insomnia and its influence on daytime brain function. Methods: A total of 120 patients with chronic insomnia admitted to our hospital from January 2021 to December 2022 were selected for the study. The patients were divided into groups according to the admission date, and 60 patients admitted on odd date were used as the matched group (receiving acupuncture treatment). Another 60 patients admitted on even dates were used as observation group (receiving GubenJiannao Anshen prescription combined with acupuncture treatment). The apparent rate, total response rate, Pittsburgh sleep quality index (PSQI) score, daytime insomnia symptom scale (daytime insomnia symptom scale) score were compared between the two groups. DISS), hyperarousal scale (HAS), incidence of adverse reactions, and short form 36 questionnaire (SF-36). Results: (1) The apparent rate was 71.67% in the observation group and 53.33% in the matched group, which was higher than that in the matched group(P<0.05). The total effective rate was 95.00% in the observation group and 83.33% in the matched group, which was higher than that in the matched group (P<0.05). (2) Pretherapy, sleep time, sleeping time, sleep quality, sleep efficiency, daytime dysfunction, sleep disorders, sleep medication scores and total scores of the two groups were compared (P>0.05); Post-treatment, the above scores of the two groups were decreased to different degrees, and the observation group was lower than the matched group(P<0.05). (3) pretherapy, DISS scores and HAS scores of the two groups were compared (P>0.05); Post-treatment, the above scores of the two groups were decreased to different degrees, and the observation group was lower than the matched group (P<0.05). (4) Post-treatment, the probability of adverse reactions such as nausea, vomiting, headache, dizziness, bitter mouth, fatigue and weakness, abnormal liver and kidney function was 6.67% in the observation group and 3.33% in the matched group, compared between the two groups (P>0.05). (5) pretherapy, the quality of life scores of the two groups were compared (P>0.05); Post-treatment, the quality of life scores of both groups were increased to different degrees, and the observation group was higher than the matched group (P<0.05). Conclusion: GubenJiannao Anshen prescription combined with acupuncture and moxibustion in the treatment of chronic insomnia can significantly improve the discernibility and total effective rate, improve the sleep disorder, improve the daytime brain function, and improve the excessive awakening state, and promote the quality of life of patients with high safety. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article summarized the integrated traditional Chinese and western medicine nursing of a patient with vestibular neuritis accompanied by medullary infarction. Comprehensive nursing interventions such as lifestyle support, dietary guidance, vestibular function rehabilitation exercise and psychological care were carried out. According to the clinical symptoms analysis and syndrome differentiation, Traditional Chinese Medicine nursing techniques including auricular acupoint pressing, moxibustion, Chinese herb medicine foot bath, Chinese herb medicine collapse and acupuncture were conducted to relieve the dizziness symptoms and improve the body constitution and health of the patient. (本文总结1例前庭神经炎伴延髓梗死患者的中西医结合护理经验。根据疾病证型, 在生活护理、饮食护理、前庭康复训练、心理护理等常规护理措施的基础上, 结合中医辨证施护, 采取耳穴压丸、艾灸、中药泡足、中药塌渍、针灸等中医特色护理技术, 有效缓解患者的头晕症状, 改善患者体质, 对促进患者健康起到积极作用。)

This paper summarized the Nursing of a patient with post-stroke constipation of Qi-deficiency type treated by Baliao acupoints moxibustion and acupuncture combined with oral administration of Yiqi Runchang decoction. A comprehensive assessment of nursing risk was carried out before treatment. Traditional Chinese Medicine external treatment such as moxibustion and acupuncture at Baliao acupoints were performed to improve the recovery of intestinal function. The patient received oral administration of Yiqi Runchang decoction to regulate the body constitution. In addition, a prescription of drinking habits was administrated to promote defecation, and other interventions such as dietary guidance, exercise and emotion care were carried out to relieve the symptoms of Qi-deficiency syndromes. (本文总结灸八髎穴联合内服益气润肠中药汤剂治疗1例中风后气虚便秘患者的护理体会。在完善护理评估的基础上, 遵医嘱给予八髎穴艾灸、针灸等中医外治疗法, 以增强肠道蠕动, 缓解便秘; 给予益气润肠中药汤剂内服, 从根本上调理; 同时基于子午流注理论, 为患者开具饮水处方, 以软化粪便, 促进胃肠蠕动, 利于排便; 结合患者的疾病特点予以饮食调护、运动疗法和情志护理。经过10 d中医内服外用联合治疗以及辨证施护, 患者气虚便秘症状得到有效改善。)

In people with cancer, certain chemotherapy drugs can have hiccups as a side effect, seriously affecting the quality of life. According to the Traditional Chinese Medicine theory, the chemotherapy-induced hiccup is associated with Zangfu, blood stasis and syndrome of Zhuodu and Huoxie. This paper summarized the etiology, pathogenesis and nursing countermeasures of chemotherapy-induced hiccup, investigate the key issues in Traditional Chinese Medicine therapy by syndrome differentiation, and provided reference for precision treatment and care of patients with chemotherapy-induced hiccup. (化疗相关性呃逆是肿瘤患者治疗过程中常见的并发症, 严重影响患者生活质量。中医认为化疗相关性呃逆与肿瘤疾病、化疗药物以及脏腑、淤血、浊毒、火邪均有关。本研究对中医中关于呃逆的病因机制以及治疗和护理方法进行总结, 探讨中医治疗呃逆的辨证要点, 旨在为化疗相关性呃逆的精准化治疗和护理提供参考。)

Background With the accumulation of high-quality evidence, the clinical effectiveness of acupuncture for migraine has been increasingly recognized. Numerous acupuncture clinical studies in China highlight and validate various acupuncture intervention schemes through clinical trials. Integrating and selecting these advantageous schemes to guide clinical practice has become a new focus in acupuncture research. Objective To conduct multicriteria decision making (MCDM) by using technique for order preference by similarity to an ideal solution (TOPSIS) method based on Meta-analysis, screen optimized treatment plan (OTP) of acupuncture for migraine and explore the ideas for constructing OTPs of acupuncture. Methods Wanfang Data, VIP, CNKI, SinoMed, PubMed, Web of Science, and EmBase were searched by computer for randomized controlled trials (RCTs) on acupuncture treatment for migraine published before April 2022. Two researchers independently screened the literature, extracted basic characteristics of literature〔author, year of publication, sample size, cure rate, efficiency rate and visual analogue score (VAS), etc.〕, and assessed the quality of the RCTs by using modified Jadad scale. Acupuncture treatment plans for migraine were summarized based on the characteristics of the included RCTs, and Meta-analysis was performed. The relative risk (RR) of cure rate and efficiency rate, and the mean difference (MD) of VAS scores for each plan were extracted based on the Meta-analysis results. The treatment frequency and score of the modified Jadad scale were calculated for each plan using sample size as the weight. The data were all included in the MCDM analysis, the weights of different decision criterion were determined using the entropy weight method. The TOPSIS method was finally used to select OTP of acupuncture for migraine. Results A total of 17 RCTs were included and categorized into 8 types of treatment plans of acupuncture for migraine (Tongyuan acupuncture, six-spirit points, bone-nearby acupuncture, conventional acupuncture, Gallbladder Meridian acupoints, head acupoints, penetration needling method and Siguan acupoints) according to the results of Meta-analysis. The TOPSIS evaluation indicated that the treatment plan of acupuncture focusing primarily on head acupoints is OTP, involving needling the head acupoints of Fengfu, Touwei, Toulinqi, Taiyang, Shuaigu, and Fengchi once daily or every other day, with an average treatment number of 11, with the main advantages of shorter treatment time and significant reduction in VAS. Conclusion The OTP of acupuncture for migraine screened and constructed in the study can provide reference for clinical application. The utilization of the entropy weight-TOPSIS method based on Meta-analysis presents a novel approach for constructing the OTPs of acupuncture for migraine.

Patients with diabetes will suffer from systemic vascular injury and various complications due to the continuous increase of blood sugar. Diabetes has become a member of the epidemic that seriously threatens human health through concentric cerebrovascular disease, tumors, etc. With the great achievements in the clinical practice of Traditional Chinese Medicine nursing in China, Traditional Chinese Medicine nursing intervention for diabetes is based on the basic theory and practical guidance of Traditional Chinese Medicine, exploring the research of appropriate techniques of Traditional Chinese Medicine nursing to prevent and treat diabetes, and providing better help for the treatment of complications of diabetes patients. This article reviewed the status quo of Traditional Chinese Medicine nursing for diabetic patients in recent years, aiming to play a positive role in improving Traditional Chinese Medicine nursing for diabetic patients and controlling the condition of diabetes. (糖尿病患者会因持续血糖增高导致其全身性血管损伤及各种并发症发生, 是常见的威胁人类健康的流行病之一。糖尿病中医护理干预立足于中医基础理论和实践指导, 探索中医护理适宜技术防治糖尿病的研究, 为糖尿病患者的治疗提供更多方案。本研究就近年来糖尿病患者的中医护理现状进行综述, 旨在为完善糖尿病中医护理及控制糖尿病病情提供参考。)

Objective To investigate the effect of acupuncture treatment of migraine by the method of Tiaoshen Shugan acupuncture. Methods A retrospective study was conducted on 80 migraine patients admitted to Huazhong University of Science and Technology Union Shenzhen Hospital from October 2022 to March 2023. The patients were divided into a control group (n=38) and a research group (n=42) according to different treatment methods. The control group received flunarizine treatment, while the research group received acupuncture treatment with Tiaoshen Shugan method in addition to flunarizine. The treatment efficacy, incidence of adverse reactions, clinical symptom scores before and after 4 weeks of treatment, hemodynamics［blood flow velocity in anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA)］, vascular-related bioactive substances ［plasma calcitonin gene-related peptide (CGRP), endothelin-1 (ET-1)］, and quality of life ［migraine-specific quality of life questionnaire (MSQ)］ were compared between the two groups. Results The research group exhibited a higher overall effective rate compared to the control group(92.86% vs 76.32%, P＜0.05). After 4 weeks of treatment, the severity of headaches, associated symptoms, monthly attack frequency, duration of each attack, MCA, ACA, and PCA blood flow velocities, and plasma CGRP and ET-1 levels were significantly reduced compared to before treatment, and the research group showed a greater reduction compared to the control group (P＜0.05). After 3 months of treatment, both groups showed improved MSQ scores compared to before treatment, and the research group had higher scores than the control group (P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Tiaoshen Shugan acupuncture treatment of migraine can effectively relieve clinical symptoms, improve cerebral hemodynamics, regulate the level of vasogenic active mediators, and improve the quality of life, with significant effects and high safety.

Objective：To explore the effect of acupuncture combined with Huatan and Progesterone prescription on patients with polycystic ovary syndrome （phlegm-dampness and difficulty）. Methods：Total 128 patients with polycystic ovary syndrome （phlegm-dampness and difficulty） were treated in the Third Affiliated Hospital of Beijing University of Chinese Medicine from Septem⁃ ber 2017 to March 2021， and randomly divided into control group and observation group， with 64 patients in each group. Control group received conventional treatment in Western medicine， and observation group was treated with acupuncture and the Huatan and Progesterone prescription. After 3 menstrual cycles， the efficacy was compared. Results：After treatment， serum TGF- β1， IL-6 and high-sensitivity C-reactive protein（ HS-CRP） levels of observation group were lower than that of control group（ P<0.05）， insulin resis⁃ tance index （HOMA-IR）， endometrial thickness and ovarian volume in observation group were lower than those in control group （P< 0.05）， serum estrogens（ E2） level in observation group was higher than that in control group， while levels of luteinizing hormone（ LH） and follicle-stimulating hormone（ FSH） were lower than that in control group（ P<0.05）. After treatment， ovulation rate（ 79.69%） and pregnancy rate（ 57.81%） in observation group were higher than those in control group， and there was no significant difference in abor⁃ tion rate between the two groups （P>0.05）. Total incidence of adverse reactions in observation group （7.81%） was lower than that in control group（ 21.88%）， and the difference was statistically significant（ P<0.05）. Conclusion：For patients with polycystic ovary syn⁃ drome （phlegm-dampness and difficulty）， combined acupuncture and Huatan and Progesterone prescription has significant effect， which can help to reduce inflammatory reaction， reduce insulin resistance， promote ovulation and pregnancy， and improve clinical efficacy. [ABSTRACT FROM AUTHOR]

AIM: To observe the effect of acupuncture on adenosine A1 receptor （A1R） in the caudate putamen （CPu） of complete Freund's adjuvant （CFA） rats, and to explore the potential mechanism of acupuncture in treatment of inflammatory pain. METHODS: Sixty-four 6~8-week-old male Wistar rats were randomly divided into saline group, model group （CFA group）, CFA+manual acupuncture （MA） group, CFA+solvent dimethyl sulfoxide （DMSO） group, CFA+A1R agonist 2-chloro-N6-cyclopentyladenosine （CCPA） group, CFA+A1R antagonist 8-cyclopentyl-1, 3-dipropylxanthine（ DPCPX） group, CFA+MA+DMSO group and CFA+MA+DPCPX group. In MA groups, on the 2nd day after modeling, the rats were needled at Zusanli points on both sides, 30 min at a time, once per day, for 7 d. Pain threshold of plantar thermal radiation was used to observe the pain response of the rats. The content of cyclic adenosine monophosphate （cAMP） in the CPu was detected by ELISA. The protein expression and phosphorylation levels of protein kinase A （PKA） and cAMP response element-binding protein （CREB） were detected by Western blot. The expression of A1R in the CPu was detected by immunofluorescence staining. RESULTS: Compared with saline group, CFA modeling significantly lowered the thermal pain threshold of the rats （P<0. 01）. Compared with CFA group, the thermal pain threshold of the rats in CFA+MA group and CFA+CCPA group was significantly increased （P<0. 05 or P<0. 01）. Compared with CFA+ MA+DMSO group, the thermal pain threshold of the rats in CFA+MA+DPCPX group was decreased （P<0. 05）. Compared with CFA group, A1R protein relative expression level and positive cells in the CPu of the rats in CFA+MA group were increased （P<0. 05 or P<0. 01）. Compared with saline group, cAMP content and p-CREB protein level in the CPu of the rats in CFA+MA group were decreased （P<0. 05）. Compared with CFA+DMSO group, cAMP content and p-CREB protein level in CFA+MA+DMSO and CFA+CCPA groups were significantly decreased （P<0. 01）. Compared with CFA+MA+ DMSO group, the levels of cAMP, p-PKA and p-CREB in CFA+MA+DPCPX group were significantly increased （P<0. 05 or P<0. 01）. CONCLUSION: Acupuncture on bilateral Zusanli can relieve inflammatory pain in CFA rats, and its mechanism may be related to A1R/cAMP/p-CREB signaling pathway. [ABSTRACT FROM AUTHOR]

The majority of postmenopausal osteoporosis (PMOP) is due to deficiency of the spleen and kidney. Acupuncture and moxibustion take significant advantages in the treatment of postmenopausal osteoporosis. By regulating the function of the spleen and kidney, acupuncture and moxibustion achieve the clinical purpose of treating osteoporosis. By summarizing the theoretical origin of PMOP in ancient Chinese medical acupuncture books, this paper explains the etiology and pathogenesis of PMOP in Chinese medicine, and starts from the etiology and pathogenesis of PMOP based on the theory of warming, upping, electroacupuncture, moxibustion in the supervision of the arteries, acupoint burying, acupoint injection and fire needle, etc. Combining acupuncture treatment mechanism with bone metabolism from the perspective of regulating Qi and blood in the whole body and breeding each other in successive days, this paper provides a new treatment idea for acupuncture treatment of PMOP. [ABSTRACT FROM AUTHOR]