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In this paper, the changes of superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in hepatopancreas of Pomacea canaliculate in Guangzhou, Shanghai and Chengdu under different temperature, salinity and dissolved oxygen environmental stresses were studied to clarify the mechanism of environmental stress on the physiology of Pomacea canaliculate. The experimental results showed that under the stress of temperature, dissolved oxygen and salinity, the SOD activity and MDA content of the hepatopancreas of the snails increased first and then decreased, and reached the maximum value at 24 h~48 h, and returned to the initial level at 72 h. Under the combined temperature-salinity stress, the SOD activity and MDA content in the hepatopancreas of the snails were higher than those under the single factor stress, and the temperature and salinity showed a synergistic effect. Under single or complex stress, SOD activity and MDA content in liver and pancreas of the snails varied from region to region. [ABSTRACT FROM AUTHOR]