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Your search keyword '"Bone Morphogenetic Protein Receptors, Type I"' showing total 3 results
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3 results on '"Bone Morphogenetic Protein Receptors, Type I"'

1. [The effect of BMP family and its receptors on animal reproduction].

Author

Guan F, Yang LG, Cheng RH, and Cao SX

Subjects
Animals, Bone Morphogenetic Protein Receptors, Type I, Bone Morphogenetic Protein Receptors, Type II, Cell Differentiation, Gene Expression Regulation, Developmental, Humans, Ovulation physiology, Protein Serine-Threonine Kinases metabolism, Receptors, Growth Factor metabolism, Bone Morphogenetic Proteins metabolism, Reproduction physiology, Signal Transduction physiology
Published
2004

2. [Studies of BMPR-IB and BMP15 as candidate genes for fecundity in little tailed han sheep].

Author

Liu SF, Jiang YL, and Du LX

Subjects
Alleles, Animals, Base Sequence, Bone Morphogenetic Protein Receptors, Type I, DNA chemistry, DNA genetics, DNA metabolism, DNA Mutational Analysis, Deoxyribonucleases, Type II Site-Specific metabolism, Female, Gene Frequency, Genotype, Growth Differentiation Factor 9, Male, Mutation, Ovulation genetics, Polymorphism, Genetic, Species Specificity, Fertility genetics, Intercellular Signaling Peptides and Proteins genetics, Protein Serine-Threonine Kinases genetics, Receptors, Growth Factor genetics, Sheep genetics
Abstract

BMPR-IB gene which controls the fecundity of Booroola Merino and BMP15 gene which affects the ovulation of Invedale and Hanna were studied as candidate genes on the fecundity of Little Tailed Han Sheep, and their mutations and genetic effects were analyzed. The results showed that there was a same mutation in BMPR-IB gene (A746G) of Little Tailed Han Sheep as that of Booroola Merino. The BB mutation genotype was superior in prolific Little Tailed Han Sheep, and the ewes with genotype BB had 0.97(P < 0.05) and 1.5(P < 0.01) lambs more than those with genotype + + in the first parity and later parities, respectively. It could be inferred that BMPR-IB gene was related with the major gene that controls the high prolificacy of Little Tailed Han Sheep. While there was not mutation of V31D or Q23Ter in BMP15 gene of Little Tailed Han Sheep, it showed that the fecundity mechanism of Little Tailed Han Sheep was different from that of Romney sheep. Then it was ruled out the possibility that the ovulation of Little Tailed Han Sheep was affected by the mutation of BMP15 gene.

Published
2003

3. [Expression of core-binding factor a1 by human skin fibroblasts induced in vitro].

Author

Deng L, Feng W, Zhang Y, and Zhu Y

Subjects
Bone Morphogenetic Protein 2, Bone Morphogenetic Protein Receptors, Type I, Bone Morphogenetic Proteins pharmacology, Cells, Cultured, Collagen biosynthesis, Core Binding Factor Alpha 1 Subunit, Core Binding Factors, Fibroblasts metabolism, Humans, Osteocalcin biosynthesis, Protein Serine-Threonine Kinases biosynthesis, RNA, Messenger analysis, Receptors, Growth Factor biosynthesis, Skin cytology, Transcription Factors genetics, Tumor Necrosis Factor-alpha pharmacology, Neoplasm Proteins, Transcription Factors biosynthesis, Transforming Growth Factor beta
Abstract

Objective: To investigate the probabilities of core-biding factor a1 (Cbfa1) expression by human skin fibroblasts induced in vitro., Methods: The fibroblasts were isolated, purified from human skin, and were grown in incubation in the media of TNF-alpha, BMP-2, and combined TNF-alpha and BMP-2 at certain concentrations, respectively. The changes in biological features of these fibroblasts correlated with osteogenesis were detected by immunohistochemistry and RT-PCR assay., Results: TNF-alpha could switch phenotype of collagen in fibroblasts from Type I and III to Type I and induce fibroblasts to express Ras and BMP type I receptor (BMPR-IA). TNF-alpha in combination with BMP-2 could induce fibroblasts to express Cbfa1 and osteocalcin mRNA., Conclusion: Human skin fibroblast could be induced into pro-osteoblast expressing Cbfa1, an osteoblast-specific transcription factor and a regulation of osteoblast differentiation, and combined use of TNF-alpha and BMP-2 was one of the regulating factors.

Published
2002

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