1. [Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma].
- Author
-
Chang BD, Cao LS, and Zhou HL
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Neovascularization, Pathologic metabolism, Neovascularization, Pathologic pathology, Carcinoma, Renal Cell metabolism, Carcinoma, Renal Cell pathology, Cyclooxygenase 2 metabolism, Kidney Neoplasms metabolism, Kidney Neoplasms pathology, Microvessels pathology, Vascular Endothelial Growth Factor A metabolism
- Abstract
Objective: To investigate the expression of COX-2 and VEGF in clear cell renal cell carcinoma (CCRCC) and their correlation with tumor angiogenesis., Methods: Envision immunohistochemistry was used to determine the expression of COX-2 and VEGF, and microvessel density (MVD) was marked by CD34 in 80 CCRCC tissues and 20 normal kidney tissues. The relationship between the above mentioned markers were analyzed., Results: Expressions of COX-2 and VEGF were noted in both CCRCC and normal kidney tissues. The positive rates of COX-2 and VEGF were significantly higher in CCRCC than in normal kidney (P < 0.05); The expression of COX-2 was correlated with TNM stage (P < 0.05), histological grade (P < 0.05) and lymph node metastasis (P < 0.05) in CCRCC, but not with age (P = 0.663) and diameter of tumor (P = 0.528). Both COX-2 expression (r = 0.851, P < 0.01) and VEGF expression (r = 0.736, P < 0.01) were significantly associated with MVD in CCRCC. There was a positive correlation between expression of cox-2 and that of VEGF in CCRCC., Conclusion: COX-2 expression is correlated with tumor angiogenesis in CCRCC. It is likely that VEGF is one of the most important mediators in the COX-2 angiogenic pathway.
- Published
- 2009