To reduce energy consumption in data center cooling systems and ensure the healthy and rapid development of data centers, this study focuses on the cooling system of a data center in Guangzhou. Addressing the efficiency variations of chillers at different Partial Load Rates (PLR), a novel model predictive control method is proposed. The study employs Gaussian process regression to establish a chillers’ operational efficiency model and utilizes Long ShortTerm Memory (LSTM) neural networks to create an outdoor wet bulb temperature time series prediction model. Based on the data center cooling load and the prediction of outdoor wet bulb temperature, the cooling system’s chilled water storage and discharge modes, storage and discharge capacity, the number of chillers, and the PLR are adjusted. This adjustment aims to partially decouple the demand and supply sides, resulting in the chillers being operated in high efficiency or turned off, thereby reducing the operational energy consumption of the cooling system. To evaluate the performance of this strategy, annual energy consumption simulations were conducted, compared to the traditional rule-based control strategy, the model predictive control strategy reduced the overall energy consumption by 3.13% and operating costs by 3.33%. [ABSTRACT FROM AUTHOR]