1. Correlation between Nonalcoholic Fatty Liver Disease and Early Left Ventricular Diastolic Dysfunction
- Author
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Fangyuan CONG, Qian XUE, Lihua DENG, Luying ZHU, Jingtong WANG
- Subjects
non-alcoholic fatty liver disease ,hepatic fibrosis ,left ventricle ,ventricular dysfunction ,root cause analysis ,Medicine - Abstract
Background As the most common chronic liver disease, nonalcoholic fatty liver disease (NAFLD) has been reported to be associated with significant changes in myocardial structure and function, but it is still a controversial issue whether it is an independent risk factor for abnormalities in cardiac structure and function. Objective To assess the correlation of NAFLD with early left ventricular diastolic dysfunction by comparing left ventricular structure and functional indices between NAFLD and non-NAFLD patients. Methods A total of 519 inpatients from Geriatric Medicine Unit, Peking University People's Hospital were enrolled during 2018 to 2020, and divided into NAFLD group and non-NAFLD group according to the results of abdominal ultrasound or CT examination. Left ventricular structural and functional indices of two groups were comparatively analyzed. Early left ventricular diastolic dysfunction was defined as the ratio of the peak velocity of the early filling (E) wave to the atrial contraction (A) wave 3.25) 〕. NAFLD patients were divided into low-risk subgroup (n=81) and medium-high risk subgroup (n=100) according to whether FIB-4 index
- Published
- 2022
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