1. [Research progress in the structure and fuction of Orthopoxvirus host range genes].
- Author
-
Liu Z, Liu Y, and Shao YM
- Subjects
- Cell Line, Cowpox virus genetics, Cowpox virus immunology, Cowpox virus pathogenicity, Cowpox virus physiology, Genetic Vectors, Orthopoxvirus genetics, Orthopoxvirus immunology, Orthopoxvirus pathogenicity, Signal Transduction, Vaccines, Synthetic immunology, Vaccinia virus genetics, Vaccinia virus immunology, Vaccinia virus pathogenicity, Vaccinia virus physiology, Viral Proteins genetics, Virulence, Host Specificity genetics, Orthopoxvirus physiology, Viral Proteins metabolism, Viral Vaccines immunology
- Abstract
Orthopoxvirus vector has a broad prospect in recombinant vaccine research, but the rarely severe side-effect impedes its development. Vaccinia virus and Cowpox virus of Orthopoxvirus have broad host range, and they have typical host range genes as K1L, CP77 and C7L. These three genes affect host range of Vaccinia virus, disturb the cell signaling pathways, suppress immune response and are related to virulence.
- Published
- 2013