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Objective To explore the therapeutic effect of fibrinogen concentrate and cryoprecipitate on severe postpartum hemorrhage in puerpera with placenta accreta under the condition of transfusion of suspended red blood cells and fresh frozen plasma. Methods The clinical data of puerpera with placenta accreta whose blood loss was more than or equal to 50% of the total blood volume within 3 hours in our hospital from January 2009 to June 2021 were retrospectively analyzed. Based on the blood transfusion components, they were divided into fibrinogen concentrate group (group A) and cryoprecipitate group (group B). The coagulation function, blood transfusion units and adverse outcomes of the two groups were analyzed. Results A total of 201 puerpera with severe postpartum hemorrhage due to placenta accreta were included in this study, including 102 cases in group A and 99 cases in group B. The levels of prothrombin time, activated partial thromboplastin time and fibrinogen in group A and group B after blood transfusion were not significantly different from those before delivery (P>0.05). There was no significant difference in blood transfusion volume of suspended red blood cells [(8.18±2.72)U vs (7.90±2.19) U] and fresh frozen plasma [(823.53±258.39)mL vs (804.04±224.94)mL] between group A and group B (P>0.05). There was no significant difference in the incidence of DIC (18.6% vs 21.2%), hysterectomy (26.5% vs 28.3%) and hemorrhagic shock (10.8% vs 13.1%) between group A and group B (P>0.05). Conclusion If puerpera with placenta accreta received both suspended red blood cells and fresh frozen plasma, similar therapeutic effect in severe postpartum hemorrhage was observed between fibrinogen concentrate vs cryoprecipitate. Fibrinogen concentrate has the advantages of rapid preparation, convenient storage and transportation, and can lower the demand for blood products.

Objective To retrospectively analyze the guiding significance and effect of thromboelogram (TEG) in the clinical use of cryoprecipitation. Methods A total of 289 patients with fibrinogen reduction, admitted to our hospital between January 2018 and December 2021, were collected. They was divided into control group (using coagulation examination and clinical feature as the transfusion criteria) and observation group (above parameters plus TEG). The TEG index in the observation group before and after transfusion and Fg, APTT, PT, and TT in 2 groups of patients before and after transfusion were monitored. The efficacy and prognosis of different blood products and cryoprecipitate were compared between 2 groups of patients.) Results The efficacy of choprecipitate transfusion was better in the observation group than the control[Fg index after transfusion (g / L) 1.92±0.92 vs 1.80±1.00, P

Objective To analyze the changes of fibrinogen (Fg) and Ⅷ factor levels of cryoprecipitated coagulation factors prepared by different methods and post-preparation quick-freezing time. Methods The fresh frozen plasma (FFP), prepared from 400mL whole blood, was randomly divided into 6 groups(group A1, A2, A3, B1, B2, B3) with 20 eliquots each, to prepare cryoprecipitate coagulation factors. Group A1, B1 were prepared by automatic cryoprecipitation preparation instrument. group A2, B2 applied the instrument after centrifugation and group A3, B3 were prepared manually. The quick-freezing time after preparation in group A1-A3 and B1-B3 were different(within 1 hour vs. more than 1 hour after preparation). The automated coagulation analyzer was used to measure Fg and Ⅷ factor levels in six groups, and further statistical analysis was carried out. Results The Fg content (mg) of six groups were 245.29±27.44 in group A1, 227.13±18.68 in group A2, 221.11±20.95 in group A3, 182.12±9.15 in group B1, 163.68±15.50 in group B2, and 155.61±19.28 in group B3, respectively. The Ⅷ factor levels(IU) were of six groups were 115.86±27.99 in group A1, 93.79±36.29 in group A2, 91.92±34.75 in group A3, 83.04±18.82 in group B1, 66.33±19.57 in group B2, and 69.34±13.26 in group B3, respectively. There were no significant differences in gender or age between group As and groups Bs. The levels of Fg and Ⅷ factors in group A1 were significantly higher than those in group A2 and group A3 (P

Objective To understand the current situation of blood components distribution in domestic prefecture-level blood stations through analyzing the components distribution data of 24 prefecture-level blood stations in China. Methods The data of components distribution of 24 blood stations from 2017 to 2020 as well as the data of blood deployment of 24 blood stations from 2019 to 2020 were collected and analyzed. Results From 2017 to 2020, positive annual growth in red blood cells, plasma and cryoprecipitate was observed in 22, 19 and 15 out of the 24 blood stations, and the annual growth median rate of above three components was 5.24%, 3.80% and 3.25%, respectively. Among the 24 prefecture-level blood stations, 23 carried out the preparation of cryoprecipitate. Conclusion The distribution of red blood cells, cryoprecipitate and plasma in prefecture-level blood stations is increasing year by year. However, there is a overstock of plasma, and most blood stations need blood employment.