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The efficacy of yeast/zinc fermentation products in scalp care were studied from the aspects of safety, oil control and dandruff removal, and hair follicle maintenance. The safety of yeast/zinc fermentation products was tested through human patch testing. In vitro SZ95 cell model was used to study the oil-control efficacy of yeast/zinc fermentation products. The method of qRT-PCR was used to verify the expression of oil-secretion-related genes SREBP-1c, PPARG, and PI3K. Spectrophotometry was used to test the effect of yeast/zinc fermentation products on 5α-reductase. The oil-control effect of yeast/zinc fermentation products on scalp and the maintenance effect on hair follicles were studied through human efficacy testing and in vitro hair follicle model, respectively. The results showed that the yeast/zinc fermentation products at a content of 5% was safe and harmless to human health; the yeast/zinc fermentation products with a content of 0.8%-1.5% could significantly inhibit the activity of 5α-reductase. The yeast/ zinc fermentation products at a content of 0.5%-2.0% could significantly inhibit the secretion of oil in SZ95 cells in vitro, and significantly downregulate the expression of oil-secretion-related genes SREBP-1c and PPARG. The yeast/ zinc fermentation products at content of 1.0% and 2.0% could significantly inhibit the expression of PI3K. The yeast/zinc fermentation products at a content of 5% could significantly reduce scalp oil secretion, improve hair follicle cycle, and promote hair shaft growth. Therefore, the yeast/zinc fermentation products had certain scalp care effects and had positive effects in controlling oil, improving hair follicle health, and promoting hair shaft growth. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy and safety of a Compound Acid in improving seborrheic dermatitis of the scalp. Methods Fifty patients with seborrheic dermatitis who met the inclusion criteria were enrolled. The subjects underwent scalp brushing with Compound Acid for a total of four brushings, with the first acid brushing on the day of enrollment and subsequent brushings at one-week interval. Symptom scores were assessed before each acid brushing. A follow-up examination was conducted two weeks after the last acid brushing. Clinical signs and symptoms such as papules, greasiness, erythema, and dandruff were scored using skin microscopy. The status of Malassezia infection was detected using fungus fluorescent microscope. A questionnaire was used to evaluate subjects' scalp itching and pain. Results Forty-seven subjects completed this study. Following the use of the Compound Acid, subjects showed significant improvements in maculopapule scores (from 2.09±1.25 to 0.13±0.34), greasiness scores (from 3.19±0.77 to 0.87±0.65), erythema scores (from 3.23±0.63 to 0.43±0.68), and dandruff scores (from 3.26±0.94 to 0.55±0.65) (all P

Objective To investigate the efficacy and safety of a Compound Acid in improving seborrheic dermatitis of the scalp ・ Methods Fifty patients with seborrheic dermatitis who met the inclusion criteria were enrolled・ The subjects underwent scalp brushing with Compound Acid for a total of four brushings, with the first acid brushing on the day of enrollment and subsequent brushings at one-week interval・ Symptom scores were assessed before each acid brushing・ A follow examination was conducted two weeks after the last acid brushing・ Clinical signs and symptoms such as papules, greasiness, erythema, and dandruff were scored using skin microscopy・ The status of Malassezia infection was detected using fungus fluorescent microscope・ A questionnaire was used to evaluate subjects' scalp itching and pain. Results Forty-seven subjects completed this study・ Following the use of the Compound Acid, subjects showed significant improvements in mac-ulopapule scores （from 2. 09 ± 1. 25 to 0. 13 ± 0. 34）, greasiness scores （from 3. 19 土 0. 77 to 0. 87 ± 0. 65), erythema scores (from 3. 23 ± 0. 63 to 0. 43 ±0. 68), and dandruff scores (from 3. 26 ± 0. 94 to 0. 55 ± 0. 65) (all P < 0. 01)・ In 95. 74% of patients, Malassezia was changed from positive to negative・ Subjective scores for scalp itching and pain were improved from 3・ 21 ± 0. 75 to 0. 57 ± 0. 58 and from 1. 70 ± 1. 27 to 0. 50 ± 0. 60, respectively (both P < 0. 01)・ No adverse reactions were reported throughout the study・ Conclusion The compound acid is effective and safe for seborrheic dermatitis, including improvements in scalp itching, maculopapules, greas・ iness, dandruff and scalp pairu. [ABSTRACT FROM AUTHOR]

Copyright of Detergent & Cosmetics is the property of Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Detergent & Cosmetics is the property of Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To collect single piece of dandruff with microscopes to improve the regular EZ-tape method for DNA extraction and genotyping, increase the utilization of samples, reduce the miss rate as well as the proportion of genotyping results of mixed stains. Methods The insides of the hats worn by two volunteers were stuck by EZ-tape and scotch tape respectively. DNA on EZ-tape was directly extracted using traditional method. Single piece of dandruff was collected from the scotch tapes under microscope. The two kinds of methods were both performed under continuous oscillation and standing digestion, respectively. DNA was extracted through Chelex-100 method, and STR genotypes were obtained after amplification and electrophoresis. The results of STR genotypes obtained by EZ-tape method and single piece of dandruff analytical method were compared. Results Miss detections happened in 11 samples （45.8%） by EZ-tape method and only single-source typing results were obtained. Ten samples （41.7%） showed the genotype results of mixed stain and six of which showed allele insertions and deletions. The genotype results were obtained successfully using the single piece of dandruff analytical method, and two samples showed mixed stain genotype. The number of exact typing processed by oscillation was higher than that by standing digestion （P

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A double-blind, comparative study was performed on the usefulness of rinse containing miconazole nitrate (COFRM) compared to rinse without the reagent for the treatment of dandruff, when together with shampoo containing miconazole nitrate (COF). This study showed that both COFR and COFRM had about 80% utility. On the other hand, though it was not significant, enhanced improvement of itching by COFRM compared to COFR was detected 2 weeks after start of the examination. These results suggest that by mixing the miconazole nitrate with not only the shampoo but also rinse, the reagent more certainly remained on the scalp so that proliferation of the Malassezia was disturbed. Therefore, the effectiveness could clearly be more practically felt at the early stage. Collectively, these results indicate that COFRM was a useful rinse that allowed the effect to actually be felt in the short-term when used together with COF and contributed to the compliance improvement. [ABSTRACT FROM AUTHOR]