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In order to solve the problems of uneven size and difficult preparation methods of drugloaded microspheres, and to better apply them in clinical fields such as tumor treatment and cartilage repair. In this paper, drug-loaded polymer microspheres were prepared from polyvinyl alcohol, gelatin and sodium alginate by free radical polymerization, Schiff base reaction and calcium ion coordination reaction. It was characterized using instruments such as infrared spectroscopy, scanning electron microscopy, and ultraviolet-visible spectrophotometer. The results indicate that the three drug-loaded microspheres prepared in this article have uniform size, easy degradation of materials, and can meet the drug release requirements in cancer treatment. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Cystamine (CYS) and deoxycholic acid (DOCA) were used as raw materials to synthesize cystamine modified deoxycholic acid (CD), and then the amino group (―NH2) of CD and the carboxyl group (―COOH) of polygalacturonic acid (PGA) were synthesized into PGA-g-CD polymer through amidation reaction. The polymer was self-assembled into micelles in the aqueous solution through dialysis. Doxorubicin (DOX) was used as a model drug, it was encapsulated in the hydrophobic core of the micelles. By regulating the feed ratio of n(―NH2)∶n(―COOH), the drug-loading performance of the micelles was controlled. The polymers were characterized by 1H-nuclear magnetic resonance spectroscopy and Fourier transform infrared spectroscopy, and the substitution degree (DS) of CD in the polymer was measured in sequence. The structure, drug loading and drug release properties of the polymer micelles were tested using transmission electron microscope, dynamic light scattering and Zeta potential analyzer, etc. The optimal feed ratio is n(―NH2)∶n(―COOH) = 1.3∶1. Under this condition, the DS in the polymer is 31%, and the critical micelle concentration is 0.025 mg/mL. The drug loading capacity and encapsulation efficiency of the micelles reach 11.53% and 60.68%, respectively. The particle sizes of the polymer micelles and the drug-loaded micelles are (208.5±4.1) nm and (296.1±0.3) nm, respectively. And the polydispersity index values are 0.215±0.008 and 0.101±0.053, respectively. Under the reductive condition, the cumulative drug release amount within 36 h reach 78.8%, compared to 22.9% in the non-reductive environment, showing good reductive responsiveness. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Polymer Materials Science & Engineering is the property of Sichuan University, Polymer Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Plastics / Zhongguo Suliao is the property of Journal Office of CHINA PLASTICS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Supramolecular hydrogels as biomaterials have been widely investigated for medical applications. However, the inadequate strength and stability of supramolecular hydrogels limit their applications in dressings, stents and drug carriers. In order to improve the mechanical properties of supramolecular hydrogels, a graphene oxide-hyaluronic acid-polyethylene glycol supramolecular hydrogel (GHCAP)is successfully prepared by the host-guest interaction of cyclodextrin and adamantane functional groups, with hyaluronic acid grafted cyclodextrin and graphene oxide (GO)as the main polymers and four-arm polyethylene glycol grafted adamantane as guest polymers. The elastic modulus of GHCAP-functionalized hydrogel is significantly increased compared with that of hyaluronic acid-polyethylene glycol supramolecular hydrogel (HCAP)without graphene oxide, and the loading rate of GHCAP-functionalized hydrogel for cichoric acid drugs reached 43. 38% under the same conditions. Hence, the supramolecular hydrogels of GHCAP are expected to have wide application in the fields of medical biomaterials such as tissue dressings and drug carriers. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Tiangong University is the property of Journal of Tianjin Polytechnic University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Textile Leader is the property of China Textile Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shenyang Pharmaceutical University is the property of Shenyang Pharmaceutical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Polymer Materials Science & Engineering is the property of Sichuan University, Polymer Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this study, combining the characteristics of nano-Fe3O4, mesoporous silica, and graphite phase carbon nitride quantum dots, a core-shell nano-carrier material Fe3O4@SiO2-NH2@g-C3N4 with a dual response of magnetic and photothermal control for drug release was synthesized. The mesoporous silica shell（SiO2） provides a loading space for the drug, and the organic carbon chain and amino groups on the inner surface of the material play the role of adsorbing the drug and blocking the pores.In the magnetic field,the drug carrier can maintain a very low release amount.When the temperature of the carrier was increased by photothermal action,the active ingredient of the drug released quickly.The X-ray diffraction,transmission electron microscopy,infrared spectroscopy, N2 isothermal absorption and desorption,VSM magnetic intensity and Zeta potential analysi were employed to characterized the relevant properties of the materials.And the effect of controlled drug release was analyzed by in vitro release experiments.The results show that pH regulation,magnetic field and infrared light can effectively regulate the release rate of drugs,and the temperature also plays a synergistic role in the release rate of drugs,and plays an on-off switch release role in the magnetic field. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Pulp & Paper is the property of China Pulp & Paper Magazines Publisher and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Formyldeoxycholic acid modified Fe3O4 nanoparticles (FDCA-MNPs)have been successfully constructed. The structure, morphology and magnetic properties of FDCA-MNPs are characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM)and vibrating sample magnetometer. Oxytetracycline (OTC) is used as a model drug to evaluate the drug loading and release behaviors of FDCA-MNPs. The maximum loading of OTC is 59. 7 mg/g, and the loading behavior follows Freundlich adsorption balance equations with multilayer adsorption．Furthermore, FDCA-MNPs@OTC shows a higher release rate at pH=9 (11. 8%)than that of pH=7 (8. 8%). The bacteriostatic activities of FDCA-MNPs, OTC, FDCA-MNPs@OTC against E. coli are compared in vitro. The results show that FDCA-MNPs have no inhibition-activity for E. coli, meanwhile, FDCA-MNPs@OTC displays better sterilization ability than OTC at the same concentration. The minimum antibacterial concentration is 3 μg/mL, and the antibacterial rate reaches 97. 8%. It is proved that the synergistic effect of drug carrier and drugs reveals good antibacterial properties and reduce the dosage of antibiotics. [ABSTRACT FROM AUTHOR]

Dehydroabietol polyoxyethylene（10）ether（DA（EO）10H）is condensated with epichlorohydrin in the presence of boron fluoride diethyl etherate firstly，and then dehydroabietyl polyoxyethylene glycidyl ether （DA（EO）10GE）is obtained through dehydrochlorination of the condensation product in the presence of NaOH. DA（EO）10GE grafted hydroxyethyl chitosan （DA（EO）10GE-g-HECTS） is prepared through grafting DA（EO）10GE to hydroxyethyl chitosan（HECTS）. The hydrogels based on DA（EO）10GE-g-HECTS are prepared through cross-linking reaction between Genipin and DA（EO）10GE-g-HECTSs. The increase of molar ratio of DA（EO）10GE versus sugar unit could result in the increase of grafting degree（DG）of DA（EO）10GE-gHECTSs，the gelation time of DA（EO）10GE-g-HECTS/Genipin with high DG is longer than that with low DG， and increasing the Genipin amount could improve the capability of DA（EO）10GE-g-HECTS/Genipin to form hydrogel. The relation between the cumulative release rate of Chloramphenicol loaded in DA（EO）10GE-g-HEC/ GE gel and times in artificial intestinal fluid could be well described by Boltzmann function，and the final cumulative release rate could be improved by increasing the DG or decreasing the Genipin dosage. The release behavior of drug loaded in the hydrogel which is formed by the cross-linking reaction between DA（EO）10GE-gHECTS with low DG and Genipin accords with the characteristics of first-order kinetic equation. [ABSTRACT FROM AUTHOR]

BACKGROUND: In recent years, studies have found that statins have significant effects on regulating bone metabolism, repairing bone microstructure, inhibiting inflammation, promoting cell proliferation, repairing vascular endothelium, and regulating signal pathway conduction. OBJECTIVE: To optimize the preparation parameters of atorvastatin calcium sustained-release microspheres, to prepare sustained-release microspheres with large drug loading and regular morphology. METHODS: The bovine serum albumin sustained-release microspheres loaded with atorvastatin calcium were prepared by desolvent method. The main factors affected the preparation of the microspheres were screened out. The four key related factors were bovine serum albumin concentration (40, 70, 100 g/L), pH value (7, 8, 9), dosage of atorvastatin calcium (200, 300, 400 μg), and ethanol addition rate (0.2, 0.5, 1 mL/min). The optimal preparation conditions of large drug loading were screened by orthogonal test. Atorvastatin calcium-loaded bovine serum albumin sustained-release microspheres were prepared under optimal parameters and placed in PBS for sustained-release performance testing. RESULTS AND CONCLUSION: (1) The optimum preparation parameters were as follows. The concentration of bovine serum albumin was 100 g/L; the pH value was 7; the dosage of atorvastatin calcium was 400 μg; the addition rate of ethanol was 0.2 mL/min. (2) The microspheres prepared under this parameter had regular morphology and smooth surface. The particle size was (425.0±13.8) nm and the encapsulation efficiency of drug loaded microspheres was up to 85.70%. The in vitro release time could last for more than 48 hours, and the cumulative release reached 73% which had a relatively good sustained release effect. (3) It is indicated that the stable sustained-release microspheres loaded with atorvastatin calcium were successfully prepared. The sustained-release microspheres with high drug loading and stability can achieve sustained drug release. [ABSTRACT FROM AUTHOR]

Polyelectrolytes (PEs) are a class of polymers with ionizable groups on molecular chains and could dissociate into a highly charged polymeric molecule in ionizing solvent. According to their surface charges, PEs can be classified into three groups: cationic PEs, anionic PEs and amphoteric PEs. PEs have received the attention of scientists for nearly a century ever since the discovery that some natural PEs could interact in water to form colloidal complexes known as polyelectrolyte complexes (PECs). PECs with three-dimensional macromolecule structure can be formed by mixing opposite charged PEs in solution. Formation of PECs will significantly influence the solubility, rheology, turbidity and conductivity of polymer solution and as-formed PECs contain the feature of stimulus responsiveness to change of external environment. Layer-by-layer self-assembly (LBL) of multilayers based on alternately adsorbing opposite charged PEs or multi-charged molecules on solid surfaces is a simple and multifunctional interface supramolecular self-assembly technology that developed in 1990 s. With the application of LBL technology, PECs with certain structures and properties are designed and are widely used in different kinds of industry. This review focuses on the preparation method, formation mechanism, influencing factors of PECs based on LBL technology. In addition, applications of PECs in nanoreactors, drug release, biosensor and fabric flame retardant fields were also summarized. Finally, it was pointed out that future research will focus on simplifying the production process, accurately controlling over the structure and realizing the multi-function of PECs.

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diselenide bond is a kind of stimulus-responsible chemical bond with sensitive redox response, which can be in respone to oxidants or reducers, leading to breakage of their chemical bonds. It will be of great potential and research significance to develop new stimulus responsive materials by combining the responsive redox characteristics of selenium with degradable polymers, which has aroused great concern among academic circles. It is still a challenge to introduce diselenide bond into polymeric carriers. Herein, a series of diselenide. containing carbonate copolymers were designed and synthesized by ring opening polymerization (ROP) through adjusting the feeding ratio during polymerizing. The structure and molecular weight of the obtained copolymers were characterized by different methods such as nuclear magnetic resonance spectroscopy (NMR) and gel permeation chromatography (GPC). Results showed that they had suitable molecular weight, narrow molecular weight distribution and adjustable selenium mass content. Then the diselenide polycarbonates were self-assembled into micelles by dialysis method, film dispersion method and ultrasonic emulsification method, respectively. Morphology of micelles was confirmed by transmission electron microscopy (TEM). Advantages and disadvantages of these different micelle preparation methods were investigated by comparing the particle size and particle-size distribution measured by dynamic light scattering (DLS), as well as drug loading ability measured by ultraviolet spectrophotometer (UV-Vis). Dialysis method and film dispersion method were suitable in preparing the diselenide-containing polycarbonate into micelles. The average particle size of these prepared micelles was less than 200 nm. In vitro drug release experiments showed that this kind of diselenide containing polycarbonate could release drugs under the stimulation of glutathione (GSH) effectively, and the cumulative release percentages and release rates were related to the selenium content of copolymers. These results laid a solid foundation for the development and application of diselenide-containing polymers as drug carrier materials. [ABSTRACT FROM AUTHOR]

BACKGROUND: In the scheme of titanium surface modification and coating modification, the drug sustained-release system constructed by surface nanotube modification and hydroxyapatite coating modification has broad clinical application prospects. OBJECTIVE: To construct composite drug loading coating of titanium dioxide nanotube/hydroxyapatite loaded with vancomycin hydrochloride, and analyze the drug release performance and cytotoxicity of the composite coating in vitro. METHODS: A two-step anodic oxidation method was used to construct titanium dioxide nanotubes on the titanium surface, and the prepared hydroxyapatite was loaded on the surface of the nanotubes by electrophoretic deposition, so as to obtain a nanotube/hydroxyapatite composite coating structure. Subsequently, the composite coating was used as a drug-loaded platform, and vancomycin hydrochloride was loaded by physical adsorption to finally obtain a composite drug-loaded coating. The in vitro drug release properties of hydroxyapatite/vancomycin hydrochloride, titanium dioxide nanotubes/vancomycin hydrochloride, titanium dioxide nanotubes/hydroxyapatite/vancomycin hydrochloride coating were measured. Human osteoblasts were cultured with titanium dioxide nanotubes/hydroxyapatite/vancomycin hydrochloride coating extracts of different concentrations. MTT assay was used to detect cytotoxicity. Human osteoblasts were inoculated on the surface of hydroxyapatite, titanium dioxide nanotubes, titanium dioxide nanotubes/hydroxyapatite/vancomycin hydrochloride, and the changes of cell morphology were observed. RESULTS AND CONCLUSION: (1) Compared with hydroxyapatite/vancomycin hydrochloride, titanium dioxide nanotube/vancomycin hydrochloride coating, titanium dioxide nanotube/hydroxyapatite/vancomycin hydrochloride coating had a longer drug sustained-release effect. The release time exceeded 150 hours. (2) The 10%, 50%, and 100% concentration of titanium dioxide nanotubes/hydroxyapatite/vancomycin hydrochloride coating extract had no obvious cytotoxicity. The relative activity of osteoblasts was more than 70%. (3) The osteoblasts on the three kinds of coating surface grow well; the cytoskeleton was intact; and the nucleus-cytoplasm ratio of the cells was normal, which was not significantly different from the morphology of the cells in pure culture. (4) The results show that the coating of titanium dioxide nanotubes/hydroxyapatite/vancomycin hydrochloride has good drug release properties in vitro without obvious cytotoxicity. [ABSTRACT FROM AUTHOR]

Copyright of Transactions of China Pulp & Paper is the property of China Pulp & Paper Magazines Publisher and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Natural flavonoid formononetin (FN) is traditional Chinese medicine extract and has anticancer effect, but the hydrophobic structure and short half-life in vivo limit their clinical applications. OBJECTIVE: To prepare FN loaded pluronic (PF)-folic acid (FA) conjugated micelles (FN-PF-FA) and to test in vitro drug release and anticancer activity. METHODS: FA coupling PF was prepared by carbodiimide crosslinker chemical method. FN-PF-FA micelles were prepared by film hydration method. The encapsulation efficiency, drug loading and drug release performance of FN-PF and FN-PF-FA micelles were measured. The in vitro anti-cancer activity of flavin, FN-PF micelles, and FN-PF-FA micelles on folic acid-overexpressing human liver cancer HepG2 cells was measured by in vitro thiohodamine B experiment. RESULTS AND CONCLUSION: (1) The encapsulation efficiency of FN-PF and FN-PF-FA micelles was (84.12±2.15)% and (82.50±1.78)%, respectively, and the drug loading was (21.33±2.27)% and (19.73±1.58)%, respectively. (2) The release rate of both micelles in acidic environment was faster than that in alkaline environment. In the same condition, the release rate of FN-PF-FA micelles was slower than that of FN-PF micelles. (3) At the same drug concentration, the ability of FN-PF micelles and FN-PF-FA micelles to inhibit the proliferation of human liver cancer HepG2 cells was stronger than that of free FN (P < 0.05). Moreover, the inhibitory effect of FN-PF-FA micelles was stronger than that of FN-PF micelles (P < 0.05). (4) The order of drug concentration required to inhibit tumors was FN-PF-FA < FN-PF < free FN, and there was a significant difference between groups (P < 0.01). (5) Results suggested that FN-PF-FA micelles had the potential to target the release of anticancer drugs. [ABSTRACT FROM AUTHOR]

Objective: A targeted MoS2 nanodrug loading system that responds to the tumor microenvironment was prepared, and its drug loading and drug release performance were evaluated. Methods: Based on the MoS2 nanosheets synthesized by hydrothermal method, the S vacant sites of the MoS2 nanosheets were used to connect lipoic acid polyethylene glycol carboxylic acid, which was combined to the Arg-Gly-Asp (RGD) targeting molecule by amide coupling reaction. Succinimidyl 3- [2-pyridyldithio] propionate (SPDP), a linker was then chemically binding to the precedingly prepared composite material, forming the nanocarrier, MoS2-PEG-RGD-SPDP (MPRS). Further, thiolated doxorubicin (DOX) was tethered to the as-prepared nanocarrier, ultimately producing the nanodrug, MPRS-DOX. The synthesized materials were characterized by transmission electron microscope (TEM), X-ray Photoelectron Spectrometer (XPS) and nano-particle potentiometer; The drug loading performance of MPRS was tested by ultraviolet visible spectrophotometer, and the drug releasing performance of MPRS-DOX was investigated by fluorescence spectrophotometer. Results: The MPRS-DOX nanodrug-loading system was successfully synthesized. Its particle size was about 200 nm, and its Zeta potential was +28.2 mV; In addition, its drug-loading efficiency was 86.8%, and its drug-loading amount was 53.5%. In vitro drug release experiments showed that DOX release volume was the highest under the conditions of 10 mM Glutathione (GSH) and pH=5.5. Conclusion: With appropriate particle size, MPRS-DOX nanodrug delivery system is successfully prepared. Furthermore, MPRS-DOX has dual responsiveness of GSH and pH, which can realize the expected controlled drug release in simulated tumor microenvironment. This dual-response nanodrug system of GSH and pH provides a new idea for the construction of a new generation of stimuli-responsive nano-carrier system. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Multilayer films loading hydrophobic drugs usually involve synthesis and the steps are complexmplex. Therefore, we have developed a fast and simple method for multilayer films loading hydrophobic drugs. In this study, (CS/PAA),, multilayer film was constructed by layer-by-layer self-assem hly method and characterized by quartz crystal microbalance (QCM). Scanning electron microscopy (SEM) results showed that the acid treated (CS/PAA)„ multilayer film form porous structure and can spontaneously heal at 100% relative humidity. The hydrophobic drug tetracycline is loaded into the porous film by capillary action, and the micropores are blocked under the condition of 100% relative humidity, resulting in the drug molecules being encapsulated in the film and realizing a large amount of loading of the hydrophobic drug. The drug-loaded multilayer film was released in phosphate buffer solution for more than 400 h, which achieved long-term sustained release of the drug. Finally, the drug-loaded multilayer films were performed to antibacterial experiments of Escherichia coli and Staphylococcus aureus, showing good long-time antibacterial properties. This method of using acid-treated to make a pore-humidity healing properties for drug loading and sustained release provides a new idea in the field of drug release. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of East China University of Science & Technology is the property of Journal of East China University of Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Textile Leader is the property of China Textile Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Gel samples were prepared with agar and xanthan gum-locust bean gum and the rheological properties and network structures of the gels were measured. Gels including acetaminophen were also prepared and the dissolution of the acetaminophen from the gels was evaluated. When the concentration of the gels increased, the breaking stress increased in a concentration-dependent manner, while the distances between the crosslinking points of the gels became shorter. However, a relation between the breaking stress and the distance between the crosslinking points was not found by varying the kind of the gels. It is found that the difference of the gel structure decides the mesh size of the network. As a result of the dissolution characterization of acetaminophen from the gels the dissolution speed was found to be slower in xanthan gum-locust bean gum gel than in agar gel and this implies that it depends on the mesh size of the gels. This study shows that drug release is possibly controllable with the natural polymer gels by adjusting the mesh size of gels. [ABSTRACT FROM AUTHOR]

Nowadays,the advantages of traditional Chinese medicine(TCM) for treatment of tumors are increasingly prominent.Triptolide shows wide-spectrum and highly effective anti-tumor activity. Moreover,nano-carrier-based triptolide drug delivery system is more powerful in improving water solubility and pharmacokinetic behavior of the drug,but it is easy to cause toxic and side effects that should not be neglected on human body. Because of tumor vascular heterogeneity and PEGylation dilemma,nanoparticulate drug delivery systems need to overcome multiple physiological and pathological barriers from drug administration to functioning. It is difficult for traditional triptolide nanoparticulate drug delivery systems to achieve active accumulation of nano-drug in tumor tissues and specific drug release in tumor target site solely relying on enhanced permeability and retention effect of solid tumor,limiting their application and clinical transformation in treatment of tumors. Based on the traditional nano-preparation system,the new functionalized nano-drug delivery system further enhances the nano-drug enrichment,penetration and controlled release at the tumor sites,which is of great significance in improving bioavailability,anti-tumor efficacy and reducing the side effects of drugs. In this paper,we summarized and analyzed the researches on new triptolide functionalized nano-drug delivery system from four perspectives,including tumor active targeting,tumor microenvironment response,polymer-drug conjugates,and multidrug co-delivery for tumor treatment,expecting to provide ideas for in-depth research and clinical application of triptolide and some other active anti-tumor TCM ingredients.

Curcumin-loaded poly (α-isobutyl cyanoacrylate) microspheres (Cur-HP-β-CD-PiBCA) were prepared by one-step emulsification with α-isobutyl cyanoacrylate as materials, poloxamer 188 as emulsifier, and curcumin complex with hydroxypropyl-β-cyclodextrin (Cur-HP-β-CD) as drug prepared by kneading method. Effects of emulsifier and drug concentration on microspheres size and distribution, drug loading and encapsulation efficiency were investigated in detail. And the curcumin release of drug-loaded microspheres was also studied. Results showed that as the emulsifier concentration increased from 0.01% to 0.07%, particle size of the drug-loaded microspheres decreased while particle size distribution, drug loading and entrapment efficiency increased. The optimized concentration of surfactant was 0.05%. With increasing the concentration of drug from 0.03% to 0.07%, drug loading of Cur-HP-β-CD-PiBCA increased, but encapsulation efficiency decreased. Additionally, the results of drug release experiments revealed that the higher drug loading of Cur-HP-β-CD-PiBCA was, the lower cumulative release percentage was. Drug-loading of cumulative inclusions in HP-β-CD by PiBCA can improve its wettability, and increase the degree of dissolution and bioavailability.

Quercetin has a variety of biological activities and pharmacological effects, but its clinical application is limited due to its low water solubility, low bioavailability and poor chemical stability. In order to overcome the above shortcomings of quercetin and achieve better clinical efficacy, many new drug delivery systems have been studied and developed in recent years, of which nano drug delivery system has become a research hotspot. Nano drug delivery system includes nanoparticles, nanocapsules, nanoliposomes, nanomicelles, nanosuspensions and nanoemulsions, with the advantages of reducing particle size, enlarging surface area, increasing drug permeability, improving intracorporeal circulation and distribution of the drug, enhancing drug targeting and so on. This article reviewed the latest progress at home and abroad about the studies and application of quercetin in nano drug delivery system, such as increasing solubility and dissolution, elevating bioavailability, raising drug stability, delaying drug release, enhancing skin permeability, promoting antioxidant capacity and improving therapeutic effect, in the hope of providing references for further research of quercetin preparations., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)

A multiple-stimuli-responsive drug-conjugated cross-linked micelles was prepared by radical copolymerization. The chemical structure, morphology, and size of the cross-linked micelles were characterized, and the drug loading of the micelle was calculated. The experimental results indicated that the hydrodynamic size of the drug-loaded micelles were about 100 nm, and the as prepared micelles could be degraded and swelled in presence of reducing glutathione (GSH). The low critical solution temperature (LCST) of the micelle was around 39.4℃. According to the experimental results, the micelles will shrink at temperature above the LCST. Subsequently, the accumulative drug release rate was up to 91.78% under acidic (pH 5.0), reductive (GSH 10 mmol/L) and high temperature (42.0℃) conditions mimicking the tumor microenvironment, while a relatively low release rate of 1.12% was observed without stimulation. The drug-conjugated cross-linked micelles showed a strong cell uptake behavior. In the cytotoxicity assay, the micelles exhibited effective anti-cancer activity and excellent biocompatibility. In brief, the experimental results show that the as-prepared drug-conjugated cross-linked micelle exhibits multiple stimuli-responsiveness, which holds great promise for anti-cancer drug delivery.

Objectives: Development in vitro test methods for drug release and particle release from drug coated balloon to address the disadvantages and inadequacy of existing assessment methods., Methods: In vitro drug transfer test were carried out using the isolated porcine vessel as target site in the self-designed iliofemoral artery model, drug loss experiment during dilatation and retraction were added in drug release test, the particle test channel was subdivided and the size and number of the large particles were measured by microscopy combined with Image-Pro Plus software., Results: The result shows that the method is feasible and the discrimination is good. The material balance can be achieved. More detailed data can be obtained., Conclusions: The developed in vitro evaluation method provides a reference for formulation screening, in vitro bench testing and in vivo pre-clinical animal testing.