1. The Relationship between Inflammatory Cytokine Levels and Airway Remodeling in Patients with Bronchial Asthma.
- Author
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SHI Guo-qiang and DING Chen-guang
- Subjects
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PHYSIOLOGICAL effects of cytokines , *AIRWAY (Anatomy) , *INFLAMMATION , *ETIOLOGY of diseases ,ETIOLOGY of Asthma - Abstract
Objective To investigate the relationship between inflammatory cytokine levels and airway remodeling in bronchial asthma patients. Methods 106 patients with bronchial asthma were divided into exacerbation group and stable groups, there were 61 cases, 45 cases, separately, 40 cases of healthy people were selected as control group. IL-2, IL-5, VEGF, bFGF, TGF-β 1 levels were detected. Results Compared with the control group, the levels of VEGF, bFGF, TGF-β1 in stable group were significantly increased ( P < 0.05) . Compared with the control group and the stable group, the levels of VEGF, bFGF, TGF-β1 in exacerbation group were significantly increased ( P < 0.05) . The levels of IL-5 in stable group patients were significantly higher than the control group (P< 0.05) . The levels of IL-2 and IL-5 in exacerbation group patients were significantly higher than than those in the control group and the stable group patients (P < 0.05) . IL-2 and TGF-β1 showed a significant positive correlation (F < 0.05), IL-5 and VEGF, bFGF, and TGF-β1 showed significant positive correlation (P< 0.05) . Conclusion The imbalance of inflammatory cytokine levels is closely related to airway fibrosis induced by VEGF, bFGF and TGF-β1 in bronchial asthma patients, these two factors work together to lead to bronchial asthma progress. [ABSTRACT FROM AUTHOR]
- Published
- 2014