Search

Objective: To observe the effect of the Yiqimingmu solutions on electroretinogram of rats with retinal photochemical damage., Methods: Twenty-four SD rats were divided into four groups randomly: control group, model group, low dose group, high dose group. All groups except the control one were continually exposed to green fluoresent light with an level of 1900 +/- 106.9 Lux for 24 hours,which was used to establish rats retinal photochemical damage model. Different doses of Yiqimingmu solutions were respectively irrigated into rats 7 days before light expose in low dose and high dose group. Saline solutions instead was used in control and model group. At 6 hours and 6,14 days after light exposed, change of electroretinogram a wave and b wave was observed., Results: It was suggested that the difference of the average amplitude of ERG a wave and b wave was not significant between left eyes and right eyes in the control group. The average amplitude of ERG a wave and b wave decreased continually at the 6th hour and 6th day and uncovered at the 14th day after light exposed in the model group. In the low dose and high dose group, Yiqimingmu solutions had protective effect on lowing ERG a wave after rats retinal photochemical damage., Conclusion: Yiqimingmu solutions has protective effect on rats retinal photochemical damage.

In the present work we investigated the effects of glycine on the electroretinograms (ERG) and light responses of ON-type bipolar cells under dark- and light-adapted conditions in superfused, isolated crucian carp retinas. It was revealed that application of 4 mmol/L glycine significantly suppressed the b-waves and the responses of ON-type bipolar cells and the effects were blocked by co-application of 20 mumol/L strychnine. In addition, glycine had no apparent action on the PIII component (photoreceptor potential) isolated by application of 3 mmol/L glutamate. These results suggest that glycine may act on bipolar cells directly and thus modulate the activity of the ON pathway in the retina.

Computer-averaged oscillatory potentials (OPs) of electroretinogram (ERG) were recorded in 54 patients affected by different hereditary forms of retinitis pigmentosa (RP) before and after three-months of traditional Chinese medicine (TCM). This study was conducted in order to investigate the alterations of physiological function in inner part of the retina affected by RP. The results showed that OP waveforms were recordable in 22 and 27 patients before and after TCM treatment, respectively. The amplitudes of summed OPs (sigma OPs) were increased significantly in patients with different hereditary modes of RP, and also in those by clinical TCM classification after the treatment. The component-specific amplitudes of OPs were observed. In particular, OP2 showed an elevation in both dominant and nondominant patient groups, while OP3 only showed an elevation in the dominant group. The results suggest that OP2, which represents mainly cone OP activity, could be improved in the patients extensively; and OP3, which represents mainly rod OP activity, could be improved only in the patients with less advanced retinal degeneration. These data provide evidence that visual function in the inner retina of patient with RP could be improved to a certain extent with TCM treatment.

23 cases including 45 eyes of diabetic retinopathy treated with nourishing Yin, tonifying Kidney and blood-activating herbs were presented. The results showed that the serum viscosity and cholesterol were markedly decreased (P less than 0.01), and the implicit times of a-wave and b-wave in flash electroretinogram(F-ERG) were significantly advanced than those of themselves before treatment (P less than 0.01 and P less than 0.05 respectively). The visual acuity in most cases was improved and the effective rate was 64.44%. The therapeutical mechanism for diabetic retinopathy used by nourishing Yin, tonifying Kidney and blood-activating herbs were discussed. The authors suggested that the Chinese herbs probably could change the chemical and physical properties of blood, promote the ocular circulation and the absorption of sludged blood and decrease the retinal ischemia.