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Objective: To study the effect of Lentinan Injection on the fibrin level and immune function of rectal cancer patients after radical surgery. Methods: Rectal cancer patients received radical surgery in our hospital from May 2010 to October 2014 were randomly assigned into two groups, patients in the observation group received lentinan combined with FOLFOX-4 chemotherapy, the control group received FOLFOX-4 chemotherapy. The incidence of adverse reaction during chemotherapy process were observed, the fiber protein level and immune function index before and after chemotherapy were determined. Results: The incidence of gastrointestinal reactions. bone marrow suppression, liver damage, peripheral neurotoxicity, oral mucosa damage, hair loss dining chemotherapy process in observation group were lower than those of control group (P<0.05). After chemotherapy, the CD3+CD4+CD8+ cells. CD3+CD4-CD8+cells. CD19+cells. CD3-CD56+cells contents in peripheral blood and the serum IgM, IgA, IgG, FIB contents of control group were significantly lower than those before chemotherapy (P<0.05): the CD3T D4T'D8‘ cells. CD3+CD4+CD8-cells. CD3-CD56+ cells. CD3"CD56+cells contents in peripheral blood and the serum IgM. IgA. IgG contents of observation group had no difference compared with those before chemotherapy (P>0.05), the serum FEB content was significantly lower than that before chemotherapy (P<0.05): the CD3+CD4+CD8- cells. CD3+CD4-CD8+ cells. CD19+ cells. CD3-CD56+ cells contents in peripheral blood and the serum IgM. IgA. IgG contents of observation group after chemotherapy were higher than control group, FIB content was lower than those of the control group (P<0.05). Conclusion: Lentinan injection adjuvant therapy could reduce the toxic effects of FOLFOX-4 chemotherapy and improve the immune function in the treatment of rectal cancer patients after radical operation. [ABSTRACT FROM AUTHOR]