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Objective: To investigate the clinical curative effect of rt-PA thrombolysis treatment for the early cerebral infarction. Methods: 72 cases were selected from March 2013 to April 2013, then they are randomly divided into 2 groups, experimental group and control group, 36 cases in each group. The patients in control group were treated by traditional methods. The patients in experimental group was treated with thrombolysis therapy by pushing note rt-PA 5 mg mixed by saline 10 mL in vein slowly, the remaining(0.7 mg/Kg + 0.9 % sodium chloride in 100 mL) are injected and dripped off in 60 minutes. Clinical nerve function defect in 90 days, Barthe index, the recurrence rate of stroke are scored. Results: Treatment for 90 days, the total effective rate was 91.67 % in the experimental group, while it was 72.22 %in the control group; the ESS nerve function score was 89.13 _ 4.58, 67.24_ 6.37 in the experimental group and control group respectively; the Barthel index in the experimental group was 86.53_ 4.29, and 50.45_ 6.69 in the control group; A year later the recurrence rate of stroke in the experimental group was 19.4 %, while 36.1 % in control group; all above this had a significant difference between the experimental group and control group (P<0.05). In the experimental group, there were 2 cases of cerebral hemorrhage, and got better after treatment; 90 days after treatment, the morality rate had no difference in both groups with 2.78 %. rt-PA has an important effect on the early cerebral infarction treatment, can improve patient morbidity and speed up the recovery neurologic deficits, worthy of clinical promotion. [ABSTRACT FROM AUTHOR]