Search

Copyright of Journal of Shenyang Pharmaceutical University is the property of Shenyang Pharmaceutical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To study the interactions between analgesic and antiemetics in postoperative combined application by isothermal titration calorimetry, and to determine whether the same device can be administered. METHODS: The experimental samples were divided into four groups according to the clinical practice, and the compatibility of sufentanil, tramadol, oxycodone, flurbiprofen, dexmedetomidine and ondansetron was observed by isothermal titration calorimetry. The temperature of the simulated operating room was 25 °C. The thermodynamic parameters of each drug were measured for Gibbs free energy ΔG, binding constant ΔH and entropy ΔS, the corresponding reactivity spectra were obtained, qualitative analysis of data plotting was used to determine the type of reaction by comparing ΔH with T ΔS . RESULTS: The process of pairwise fusion of four groups of test samples was ΔH

OBJECTIVE: To investigate the application status of parecoxib and flurbiprofen in surgical patients from the First Affiliated Hospital of Nanjing Medical University (hereinafter referred to as ("our hospital"), to probe into the administration time, dosage and treatment course of parecoxib and flurbiprofen in different surgeries, so as to provide reference for the rational drug use in clinic. METHODS: 987 medical records were extracted from department of general surgery, cerebral surgery, thoracic surgery and orthopaedics during 2014-2015. Retrospective analysis was conducted on the application of parecoxib and flurbiprofen in patients during perioperative period. RESULTS: Parecoxib was used in before operation, during operation and after operation, single administration was mainly for before operation and after operation, and during operation was mainly for drug combination. Flurbiprofen often used in after operation, and mainly as drug combination. CONCLUSIONS: Our hospital attached more importance on the combination of non-steroidal anti-inflammatory drugs. However, the long-term observation and exploration by the clinical and pharmacy department is still necessary in order to further design the best drug combination for analgesia and obtain the most significant effect of analgesia and minimal adverse reactions. [ABSTRACT FROM AUTHOR]

Objective The purpose of this study was to investigate the preventive effect of flurbiprofen axetil or small-dose ketamine for remifentanil-induced postoperative hyperalgesia. Methods 120 anesthetized patients with ASA Ⅰ or Ⅱ were randomly divided into three groups. Group A（40 cases） was given 0.5 mg/kg of ketamine by intravenous injection，and 5 滋g/(kg.min) vein to maintain，group B（40 cases） was given 100 mg of preoperative flurbiprofen axetil by intravenous injection and group C（40 cases） had no flurbiprofen axetil or ketamine which was served as controls. After the treatment，all groups were given continuous intravenous tramadol controlled analgesia （PCIA） . Results After 1 h，2 h，4 h and 8 h， the visual analog scale（VAS） of group C was significantly higher than that of group A and group B（ < 0.05）；after 24 h， there was no statistically significant difference among the three groups in VAS scores（ > 0.05） . The number of fentanyl analgesia were 25 cases and postoperative 24 h PCIA self-control were（8.6±4.2） times，which were more than 7 cases and （3.3±2.8） times of group A，and 6 cases and （3.2 ± 2.2） times of group B（ < 0.05） . Conclusion The preoperative administration of flurbiprofen axetil or intraoperative continuously administered ketamine is able to prevent the occurrence of remifentanil-induced postoperative hyperalgesia， and it will not affect the patient regained consciousness. The method is safe and reliable，so it is worth promoting and popularizing. [ABSTRACT FROM AUTHOR]

Objective To evaluate the effectiveness and safety of postoperative analgesia with flurbiprofen on patients with vocal cord polyps after CO2 laser endolaryngeal microsurgery. Methods A total of 60 patients with vocal cord polyps after CO2 laser endolaryngeal microsurgery from March 2010 to March 2014 Changsha were randomly divided into the observation group and the control group, 30 of each group. The observation group were received 50 mg flurbiprofen intravenously for 3 consecutive days as of the first day after the operation while the patients in the control group with intravenously normal saline as the control group. The pain condition of throat and neck wasobserved by visual analogue scale (VAS) on the first, second and third days after the operation respectively, as well as the side effects related to it were also assessed. Results The VAS scores of the observation group after the operation[( 1.9±0.3), (0.5±0.1)points] were lower than those of the control group[( 3.4±0.2) , (2.0± 0.2)points] on the second and third days respectively,which had significantly statistical difference(P<0.01 ). There was no significant statistical difference (P>0.05) between the two groups concerning the total incidence rate of side effects of postoperative anal gesia such as nausea, emesis, rash respiratory depression and postoperative bleeding[26.78(8/30), 30.08(9/30)]. Conclusion Flurbiprofen injection has a good postoperative analgesia effect and low side effect rate for the patients with vocal cord polyps after CO2 laser endolaryngeal microsurgery. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the efficacy of patient-controlled intravenous analgesia (PCIA)with hydromorphone hydrochloride plusflurbiprofen axetil after endoscopic sinus surgery(ESS). Methods: One hundred patients of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, scheduled for ESS under total intraveous anesthesia with postoperative PCIA in Beijing Tongren Hospital from October 2015 to April 2016 were randomly divided into 3 groups according to the different formula of PCIA pumpin each group: Group A (hydromorphone hydrochloride 1 μg·kg(-1)·h(-1)+ flurbiprofen axetil 200 mg), Group B(hydromorphone hydrochloride 2 μg·kg(-1)·h(-1)), Group C( hydromorphone hydrochloride 1 μg·kg(-1)·h(-1)). The dosage of PCIA in each group was calculated for 50 h, and was diluted in 100 ml normal saline. All the pump was set up background infusion at a rate of 2 ml/h with a 2 ml bolus dose and a 15 min lock-time.Visual analogue scale (VAS) and Ramsay sedation scores at time points of postoperative 1, 4, 8, 12, 24, 48 h, the number of attempts to press bolus and rate of adverse effects within 48 h were recorded. The differences were compared among the groups. Results: VAS at postoperative 1, 4, 8, 12 h in Group A was (1.9±0.6), (1.8±0.6), (1.6±0.6), and (1.2±0.4) respectively, in Group B was (1.8±0.4), (1.7±0.7), (1.6±0.6), and (1.3±0.5) respectively, in Group C was (2.5±0.9), (1.7±0.7), (1.6±0.6), and (1.3±0.5) respectively. The difference among each group were statistically significant ( F =8.661, 3.105, 4.903, 13.846, P <0.05). VAS in Group A was similar to that in Group B( P >0.05), but was lower than that in Group C( P <0.05). The number of attempts to press bolus within 48 h in group A was 1.4±1.0, which was less than in Group C(2.2±1.8 , P <0.05). Ramsay sedation score at postoperative 1, 4, 8 h in Group A was (2.4±0.6), (2.2±0.6), and (2.2±0.4) respectively, in Group B was (2.8±0.7), (2.6±0.7), and (2.4±0.6) respectively, in Group C was (2.3±0.6), (2.1±0.4), and (2.1±0.2) respectively. The difference among each group were statistically significant ( F =5.660, 6.782, 7.141, P <0.05). Ramsay sedation score in group A was similar to that in Group C( P >0.05), but was lower than that in Group B( P <0.05). The total rate of adverse effects in Group A was 8.8%, which was similar to that in Group C (9.1%, χ(2)=0.001, P >0.05), but was significantly lower than that in Group B (42.5%, χ(2)=9.99, P <0.05). Conclusion: 1 μg·kg(-1)·h(-1) hydromorphone hydrochloride plus 200 mg flurbiprofen axetil is effective on PCIA for patients after ESS and can reduce the dosage of hydromorphone hydrochloride and the rate of adverse effects as well.

Chromatographic behaviors for enantiomeric separation of arylpropionic acid drugs were systematically developed by reversed phase-high performance liquid chromatography (RP-HPLC) using cellulose-tris-(4-methylbenzoate) (CTMB) as chiral stationary phase (CSP). The effects of the composition of the mobile phase, additives and temperature on chiral separation of flurbiprofen, pranoprofen, naproxen, ibuprofen and loxoprofen were further investigated. The enantiomers had been successfully separated on CSP of CTMB by the mobile phase of methanol-0.1% (v/v) formic acid except naproxen by acetonitrile-0.1% (v/v) formic acid at 25 °C. The mechanisms of the racemic resolution for the above mentioned five drugs are discussed thermodynamically and structurally. The resolutions between respective enantiomers for arylpropionic acid drugs on CTMB had significant differences due to their chromatographic behaviors. The order of resolutions ranked pranoprofen, loxoprofen, flurbiprofen, ibuprofen and naproxen. The method established has been successfully applied to the determination of the enantiomers of the five drugs in commercial preparations under the optimized conditions. It proved that the method is simple, reliable and accurate.