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1. [Recent advance in the discovery of allosteric inhibitors binding to the AMP site of fructose-1,6-bisphosphatase].

Author

Li ZM, Bie JB, Song HR, and Xu BL

Subjects
Allosteric Site, Animals, Binding Sites, Blood Glucose metabolism, Diabetes Mellitus, Type 2 blood, Enzyme Inhibitors pharmacology, Fructose-Bisphosphatase metabolism, Fructosediphosphates metabolism, Fructosephosphates metabolism, Humans, Adenosine Monophosphate chemistry, Enzyme Inhibitors chemistry, Fructose-Bisphosphatase antagonists & inhibitors, Fructose-Bisphosphatase chemistry
Abstract

Fructose-1, 6-bisphosphatase (FBPase), a rate-limiting enzyme involved in the pathway of gluconeogenesis, can catalyze the hydrolysis of fructose-1, 6-bisphosphate to fructose-6-phosphate. Upon inhibiting the activity of FBPase, the production of endogenous glucose can be decreased and the level of blood glucose lowered. Therefore, inhibitors of FBPase are expected to be novel potential therapeutics for the treatment of type II diabetes. Recent research efforts were reviewed in the field of developing allosteric inhibitors interacting with the AMP binding site of FBPase.

Published
2011

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