In the realm of phytoremediation for heavy metal-contaminated soil, the incorporation of exogenous activator regulation and intercropping has proven to be an efficacious method. To assess this, a pot experiment was conducted, examining the impact of exogenous additions of ethylenediaminetetraacetic acid (EDTA), polyaspartic acid (PASP), and the combination of both (EDTA + PASP) on the remediation of Pb, Zn, and Cd contaminated soil using Solanum photeinocarpum and Pterocypsela indica. Our findings reveal that the introduction of these activators resulted in an increase in soil pH and soil organic matter content. Notably, EDTA and PASP exhibited activation and passivation effects, respectively, on the content of available heavy metals in the soil. While EDTA+PASP had a negligible impact on the content of available heavy metals, it was observed that the addition of PASP to the soil led to a significant increase in plant height for monocropped P. indica by 5.98%, fresh weight for monocropped S. photeinocarpum by 36.82%, and dry weight for intercropped S. photeinocarpum by 52.93%. Though EDTA showed limited influence on plant biomass, it exhibited the ability to activate heavy metals within the contaminated soil. Specifically, under both monocropping and intercropping conditions, EDTA facilitated the absorption of Pb and Zn by S. photeinocarpum and P. indica. This resulted in a notable increase in the extraction of Pb by 187.63% and Zn by 21.21% in the root of P. indica. Additionally, the Zn concentration in the shoot of P. indica increased by 62.29%. Meanwhile, the introduction of PASP into the soil led to a reduction in Cd content in the shoot of monocropped and intercropped P. indica by 38.88% and 58.86%, respectively. In terms of the total extraction of Pb, Zn, and Cd by plants, the hierarchy was as intercropping^. photeinocarpum>P. indica. Under EDTA treatment, the bioaccumulation factor (BCF) for Pb, Zn, and Cd ranged from 0.119 to 0.219, 0.118 to 0.142, and 5.36 to 6.28, respectively, while the translocation factor (TF) ranged from 0.472 to 2.17, 0.968 to 1.37, and 1.31 to 2.81, respectively. Across various activator treatments, EDTA notably increased the concentration of heavy metals in the leachate, with the concentration sequence being EDTA>EDTA + PASP>PASP>CK. The maximum concentrations recorded for Pb, Zn, and Cd in the leachate were 76.1 mg/L, 31.5 mg/L, and 1.53 mg/L, respectively. In summary, the results underscore the significant promotion of plant biomass by PASP and the enhancement of Pb, Zn, and Cd extraction and enrichment in soil facilitated by EDTA in both monocropping and intercropping scenarios. While EDTA exhibited potential for improving phytoremediation in Pb, Zn, and Cd-contaminated soil, it also increased the risk of downward migration of these heavy metals. [ABSTRACT FROM AUTHOR]