Search

Your search keyword '"Hematologic Neoplasms physiopathology"' showing total 3 results
Start Over Descriptor "Hematologic Neoplasms physiopathology" Language chinese
3 results on '"Hematologic Neoplasms physiopathology"'

1. [Research progress on autophagy in hematopoietic malignancies].

Author

Tong Y, Li L, Liu H, and Qian WB

Subjects
Apoptosis physiology, Hematologic Neoplasms physiopathology, Signal Transduction, Autophagy physiology, Cell Death physiology, Hematologic Neoplasms pathology
Abstract

Autophagy is a process of bulk degradation of proteins and organelles in cytoplasm.Autophagy has many normal physiological functions in cellular catabolism; therefore is essential for cell homeostasis. In some circumstances autophagy can induces cell death, namely autophagic cell death. Recent studies have suggested that autophagy plays an important role in both normal tissue development and a variety of diseases, including cancer. Therefore, the strategy targeting autophagy pathway may represent a new way of cancer treatment.

Published
2010
Full Text
View/download PDF

2. [Experimental hematology bridging the gap between laboratory and clinic: hope of hematology].

Author

Chen Z, Chen SJ, and Zhou GB

Subjects
Animals, Humans, Clinical Laboratory Techniques trends, Hematologic Diseases genetics, Hematologic Diseases metabolism, Hematologic Diseases physiopathology, Hematologic Neoplasms genetics, Hematologic Neoplasms metabolism, Hematologic Neoplasms physiopathology, Hematology trends
Abstract

This article summarizes the progress of hematology in the recent tens years to show that experimental hematology used to pick up the 'hints' from clinical problems as the renewal of research directions and targets in experimental studies continuously. As the feedback, the results from lab investigations inserted into clinical practice and eventually made a quick modernization of hematology, which was actually a good model for the "translational research". The past few decades have witnessed tremendous advances in our understanding of normal hematopoiesis where genes dictate, epigenetics regulate, transcription factors mediate, and stem cells self-renew and differentiate. Dissection of disease pathogenesis not only elucidates molecular basis of disorders including hemoglobinopathy, aplastic anemia, hemophilia, hematopoietic malignancies such as leukemia and myeloproliferative disorders, but also provides therapeutic targets for drug development. Introduction of targeted therapies and combinatory targeting therapies greatly benefits hundreds of thousands of patients, and even turns acute promyelocytic leukemia from highly fatal to highly curable. In the 21st century the experimental hematology is entering the era of genomics and system biomedicine, and the pace of progress extrapolates to a prediction of hematologic neoplasms control in this century.

Published
2008

3. [Alterations in coagulation in patients during transplant conditioning regimen before allogeneic hematopoietic stem cell transplantation].

Author

Jiang Q, Huang XJ, Liu KY, Chen H, Chen YH, Gao ZY, and Lu DP

Subjects
Adolescent, Adult, Antilymphocyte Serum therapeutic use, Child, Cyclophosphamide therapeutic use, Female, Hematologic Neoplasms surgery, Humans, Male, Middle Aged, Partial Thromboplastin Time, Prothrombin Time, Young Adult, Blood Coagulation drug effects, Hematologic Neoplasms physiopathology, Hematopoietic Stem Cell Transplantation, Transplantation Conditioning
Abstract

Objective: To evaluate the alterations in coagulation in patients during conditioning with modified busulfan plus cyclophosphamide (BU/CY) +/- antithymocyte globulin (ATG) regimen before allogeneic hematopoietic stem cell transplantation (allo-HSCT), and to assess the effect of ATG on coagulation system., Methods: Thirty-five patients with various hematological malignancies undergoing allo-HSCT were assessed. Of them, 19 patients with HLA-matched sibling donors (group A) were conditioned with modified BU/CY regimen, 16 with HLA-mismatched family members or HLA-matched unrelated donors (group B) were conditioned with modified BU/CY + ATG regimen. Blood samples were collected before the beginning of conditioning till d + 1 after allo-HSCT. The following parameters were measured: prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fg), antithrombin (AT), D-Dimer, fibrin degradation product (FDP), platelet (BPC), liver enzymes and bilirubin. FVIII: C, FIX: C, FXI: C and FXII: C in prolonged APTT blood samples were also determined. Clinical hemorrhagic symptoms were monitored., Results: During conditioning, temporary lengthening of APTT, persistent rising in Fg and declining of BPC were observed in the two groups. Alterations of Fg and BPC were more significant in group B than in group A. Transient D-Dimer increase occurred only in group B on administration of ATG. Among intrinsic pathway coagulation factors, FXII: C and FXI: C were commonly decreased while APTT prolonged. No difference between the two groups was found with regard to PT, FDP, AT and liver parameters which remained in normal ranges. Most of patients in the two groups did not have overt bleeding manifestations., Conclusions: Modified BU/CY +/- ATG conditioning regimen can induce subclinical alterations in coagulation. The regimen containing ATG has more significant effect on coagulation parameters.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results