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Objective: Investigate the effects of Lonicera caerulea anthocyanin complex liquid preparation (compound made of Lonicera caerulea L., Polygonatum sibiricum, Inonotus obliquus, LPI) on glucose and lipid metabolism in type 2 diabetes mellitus (T2D) mice. Methods: T2D model in mice was constructed by high-fat feeding combined with streptozotocin. The mice were randomly divided into 6 groups: Blank control group, diabetes model group, low, middle and high dose sample group and metformin positive control group. After continuous intervention for 28 days, the body mass data and physiological and biochemical indexes of mice were measured and recorded, and the pathological observation of the organs of mice was performed. Results: Each dose group of LPI could increase the weight of T2D mice, improve the symptoms of organ injury, significantly reduce serum insulin level (P

An improved method was developed for the detection of 16 polycyclic aromatic hydrocarbons (PAHs) in mainstream cigarette smoke during combustion. The methodological approach involved matrix matching standard solution preparation, direct injection of the extraction solution, and measurement of standard linearity curves to quantitatively analyze the release of target compounds. Considering the diverse physical and chemical properties as well as distribution patterns of the 16 PAHs in cigarette smoke, the impact of room temperature and high-temperature ion sources on the response of target compounds was investigated. Additionally, the preparation methods of matrix solvents and the matrix effects on the quantitative results of target compounds were also explored. Furthermore, a systematic study was conducted on the smoke release distribution of commercially available cigarettes with different circumferences. The results demonstrated that direct injection of sample extract eliminates the need for sample purification, concentration, and other processing steps employed in current detection methods. This simplifies sample pretreatment procedures while reducing organic solvent usage and consumables consumption. Moreover, it resolves issues related to low operational efficiency when dealing with large quantities of samples. The use of matrix solvent to prepare standard solution effectively reduces the influence of matrix effect, and solves the technical problem of low recovery of target substance in flue gas caused by no purification treatment when using gas chromatography-tandem mass spectrometry (GC-MS/MS) to analyze 16 kinds of PAHs. Under the normal working parameters of the instrument, the electron impact ion source (EI) was used under high temperature to improve the ionization efficiency of the targets in complex matrix and to ensure the accurate analysis of targets with low concentrations. The correlation coefficients (R2) of the calibration curves for 16 PAHs are 0.996 4-0.999 8, the limits of dectection and the limits of quantification are 0.29-1.48, 0.95-4.94 ng/cigarette, respectively. Under different concentration levels, the average recovery is 87.71%-123.26%, and the precision is within 1.58%-9.45%. By analyzing the reference cigarette 3R4F, there is no significant difference between this method and those reported in the literature. The total amount of PAHs released from 58 brands of cigarette samples are 742.76-1 505.99 ng/cigarette. At the same time, with the decrease of tar content in cigarette, the release of PAHs will be reduced accordingly. This method is simple, practical, stable, and accurate, providing more technical means for the detection of trace PAHs in cigarette smoke.

Based on the latest results of near-source exploration in the Middle and Lower Jurassic of the Tuha Basin, a new understanding of the source rocks, reservoir conditions, and source-reservoir-cap rock combinations of the Jurassic Shuixigou Group in the Taibei Sag is established using the concept of the whole petroleum system, and the coal-measure whole petroleum system is analyzed thoroughly. The results are obtained in three aspects. First, the coal-measure source rocks of the Badaowan Formation and Xishanyao Formation and the argillaceous source rocks of the Sangonghe Formation in the Shuixigou Group exhibit the characteristics of long-term hydrocarbon generation, multiple hydrocarbon generation peaks, and simultaneous oil and gas generation, providing sufficient oil and gas sources for the whole petroleum system in the Jurassic coal-bearing basin. Second, multi-phase shallow braided river delta–shallow lacustrine deposits contribute multiple types of reservoirs, e.g. sandstone, tight sandstone, shale and coal rock, in slope and depression areas, providing effective storage space for the petroleum reservoir formation in coal-measure strata. Third, three phases of hydrocarbon charging and structural evolution, as well as effective configuration of multiple types of reservoirs, result in the sequential accumulation of conventional-unconventional hydrocarbons. From high structural positions to depression, there are conventional structural and structural-lithological reservoirs far from the source, low-saturation structural-lithological reservoirs near the source, and tight sandstone gas, coal rock gas and shale oil accumulations within the source. Typically, the tight sandstone gas and coal rock gas are the key options for further exploration, and the shale oil and gas in the depression area is worth of more attention. The new understanding of the whole petroleum system in the coal measures could further enrich and improve the geological theory of the whole petroleum system, and provide new ideas for the overall exploration of oil and gas resources in the Tuha Basin.

More steel scrap consumption in the iron and steel industry can not only mitigate the shortage of iron ore resources but also greatly lower production costs and carbon emissions to the atmosphere, which is a crucial link in low-carbon metallurgy. Because of the drawbacks of different factors, the amount of steel scrap consumed in the current converter steelmaking process is restricted, and the technology of multipoint adding scrap comes into play. Thus, steel scrap addition into ladles has gradually garnered attention from metallurgical experts, but there are few reports on the three-dimensional melting behavior of steel scrap in a real ladle environment with argon blowing. To examine the melting law of steel scrap in a ladle, in this study, the flow field, temperature distribution, and melting behavior of steel scrap in a 70 t refining ladle at various argon blowing rates with steel scrap addition of different specific surface areas and preheating temperatures were numerically investigated and compared using a mutiphysical mathematical model. The results revealed that the melting rate of steel scrap increases with increasing specific surface area, and bottom argon blowing can accelerate the melting of steel scrap, while the promoting effect gradually decreases with increasing specific area. With bottom argon blowing, the core temperature of steel scrap with specific surface areas of 120, 130.22, and 160.81 m2·m–3 increased by 7.06, 6.51, and 3.73 K·s–1, the melting rate was increased by 0.92, 0.88, and 0.28 cm3·s–1, and the melting time was shortened by 17, 15, and 3 s, respectively, compared with those without bottom blowing. When the initial temperature of steel scrap increases from 300 to 1000 K, the melting rate increases from 2.97 to 3.26 cm2·s–1 and the melting time is shortened by 3 s accordingly. The argon blowing rate significantly influenced the melting rate of steel scrap. When the argon blowing rate increases from 100 to 200 L·min–1, the melting time of steel scrap with specific surface areas of 120, 130.22, and 160.81 m2·m–3 is reduced from 44 to 35 s, 42 to 34 s, and 34 s to 31 s, respectively. Thus, on the premise of smooth production, the melting speed of the steel scrap in the ladle can be significantly increased by increasing the argon blowing rate and adding the slab scrap at higher initial temperatures and specific surface areas. This work offers a reference for developing steel scrap rapid-melting technology for ladles in steel plants.

The goal of palliative care is to help patients and their families improve their quality of life,reflect the core content of professional ethics of medical care,and respect the life value and personality dignity of patients,including relieving physical,mental,and psychological pain and meeting the needs of patients to prolong their lives through analgesia and controlling various symptoms.This article expounds the integration of palliative care concept into geriatric medical education,provides a sustainable development teaching mode and practical experience for the training of geriatric medical workers,improves the quality of geriatric medical education,improves the post competence of geriatric specialists,and provides certain ideas for the establishment of comprehensive and standardized geriatric medical education.

To study the effect of resting on the quality of frozen dough, the changes in the moisture state of the dough during the resting process (0, 30, 60, 90, 120 min), the moisture distribution of dough and their effects on ice crystal distribution, microstructure, and creep recovery characteristics after dough freezing were investigated. The results showed that the freezable water content in the dough was decreased by 0.96% with the extension of the resting time. The pores and number of ice crystals formed in the dough during the freezing process gradually decreased and the distribution of ice crystals became more and more uniform. The average pore area decreased from 22.65 to 11.80 with the extension of the resting time from 0 min to 120 min, and the number of pores decreased from 22.65 to 11.80 with the extension of the resting time. The maximum creep flexibility Jmax increased significantly (P

Edible jiaosu is one type of food with many bioactive substances, which is very beneficial to human health. The stability of edible jiaosu is the key and difficult point to the development to the new jiaosu products. Currently, many studies on edible jiaosu have been conducted both domestically and internationally. However, there has been no systematic induction and summary until now. Therefore, based on the existing research results, this article summarizes the detection models and evaluation indicators related to the stability of jiaosu products. It shows that the main models include the predicting shelf life dynamics models. The stability indicators mainly include the sensory evaluation, pH index, the functional evaluation, the content of activity, and the probiotic content, among which the sensory evaluation and the antioxidant activity are the main evaluation indicators for the most stability evaluation. The factors that affect the stability of edible jiaosu products include the production process conditions (breeding strain, and fermentation time), the post-processing and the storage environment. The summary shows that by selecting suitable strains or mixed strains for fermentation, reasonable adjustment of fermentation time, adopting appropriate sterilization and drying methods, other post-processing methods, and using the low temperature, dark, anaerobic conditions are all beneficial to improve the stability of jiaosu products. It is recommended to further explore the selection of advantageous strains, research on post processing techniques, and stability regulations for jiaosu processing in the future. In summary, this paper summarizes the evaluation models and indicators for the stability of edible jiaosu, pointed out that production the process conditions, the post-processing of edible enzyme products, and the storage environment have a significant impact on the stability of edible jiaosu, and proposed measures and suggestions to improve its stability. This work provides a theoretical reference basis and guidance for promoting the stability of edible jiaosu and the development of its related industries.

Objective: To elucidate the main components and mechanism of adjuvant prevention of type 2 diabetes of Citrus peel. Methods: The inhibitory activity of Citrus peel of α-glycosidase was determined in vitro. It were used to predict the material basis and potential mechanism of Citrus peel in the treatment of type 2 diabetes by network pharmacology, and verified the results by molecular docking. Results: The α-glucosidase was inhibited by 13 kinds of Citrus peel and showed a dose-effect relationship in the linear range. It was predicted that the active ingredients naringin, tangeretin and lauric acid might inhibit hyperglycemia through oxidative stress by network pharmacology and molecular docking. Citrus peel treatment of type Ⅱ diabetes was related to PI3K-Akt, Ras, HIF-1 signaling pathway in inflammation and vascular related VEGF signaling pathway. Tangeretin was the main component. Conclusion: Citrus peel had an inhibitory effect on α-glycosidase , which might play a role in the prevention of type 2 diabetes.

In the past decade, with the improvement of shale gas exploration and development theory and techno-logy, the commercial development of marine shale gas from Ordovician Wufeng to Silurian Longmaxi formations in southern China has been achieved, and the target of shale gas exploration and development is gradually shifting towards shale gas of deep and complex structural areas and new formations. In order to further promote efficient exploration and development of shale gas, a systematic review was conducted on the recent exploration and deve-lopment progress of SINOPEC shale gas and an analysis was conducted on the development trend of shale gas in China. The research results indicate that: ① The high-quality Fuling National Shale Gas Demonstration Zone has been built and a key technology system for three-dimensional development of marine shale gas has been innovatively formed. ② The large-scale and efficient development of atmospheric shale gas in Dongsheng and Baima blocks of Nanchuan has been realized, and four shale gas accumulation and dispersion models have been constructed: anticline, monocline, reverse fault blocking, and residual syncline. A fine zoning and differentiated development model and a low-cost technology system for atmospheric shale gas have been preliminarily formed. ③ The deep large-scale fields of trillions of square meters in southeastern Sichuan basin edge have been preliminarily implemented, an "overpressure rich gas" model of marine deep shale gas has been innovatively formed, and a fracturing technology system of deep shale gas in the deep range of 4 000-4 500 m has been preliminarily formed. ④ Major breakthroughs have been made successively in Jurassic of Yuanba and Puguang, Permian of Hongxing and Puguang, and Cambrian of Jingyan and Qianwei. ⑤ The future breakthrough and development of shale gas cannot be achieved without innovative research on exploration and development theory and technology. The integration of exploration and development, geological engineering, and technology and economy must be adhered to. The complexity of deep, normal-pressured, and geological characteristics of new shale gas formations should be fully understood. In addition, policy support is also required.

【Objective】By detecting the natural variation of Auxin Up-regulated F-box protein2 (AUF2) gene and exploring the elite alleles associated with agronomic traits in order to provide theoretical references for molecular marker assisted breeding of flowering Chinese cabbage.【Method】PCR amplification and sequencing was used to detect the natural variations in AUF2 gene among 156 flowering Chinese cabbage accessions. By using the mixed linear model (MLM) of Tassel 5.0 software, the correlation between the variation sites of AUF2 gene and six agronomic traits of flowering Chinese cabbage was analyzed, including plant height, single plant weight, maximum leaf length, maximum leaf width, maximum petiole length and chlorophyll content (SPAD), and the polymorphic sites significantly associated with agronomic traits would be identified. Then, elite alleles and excellent haplotypes were determined.【Result】Through sequencing analysis, a total of 34 mutation sites were detected in the 2 996 bp amplification region of AUF2 gene, including 36 haplotypes. The AUF2 gene showed high nucleotide diversity (π = 0.00503) and haplotype diversity (Hd = 0.780). Among them, 2 InDels and 26 SNPs were in the 1 498 bp upstream non-conding region, and 1 InDel and 5 SNPs were in the 960 bp coding region. No mutation sites were detected in the 538 bp downstream non-conding region. Neutral test analysis showed that Tajima's D value, Fu and Li's D* value, and Fu and Li's F* value of the AUF2 gene were positive, and deviated significantly from neutral evolutionary model. One plausible reason was that flowering Chinese cabbage population was subject to balancing selection. The association analysis showed that 4 SNPs were significantly associated with at least one of the four agronomic traits, including single plant weight, maximum leaf length, maximum leaf width and maximum petiole length. The phenotypic variation of a given trait explained by each associated SNP ranged from 5.04% to 6.52%. The haplotype Hap2, which contained elite alletes of the four SNPs mentioned above, could significantly raise the single plant weight, and remarkably increase the length of the maximum petiole.【Conclusion】There are abundant variations in the AUF2 gene, which has a significant impact on the agronomic traits of flowering Chinese cabbage. These elite alleles and excellent haplotypes of AUF2 gene will benefit the genetic improvement of flowering Chinese cabbage.

In this study, ultrasonication was applied in the whole process of dough freezing and in the maximum ice crystal formation zone, respectively, to explore the effects of ultrasonic-assisted freezing on the physicochemical and structural properties of wheat starch in dough. The results showed that compared with the frozen samples without ultrasonication, the peak viscosity of wheat starch in the dough decreased by 8.6% and 14.5%, the trough viscosity reduced by 17.1% and 13.7%, and the final viscosity increased by 11.3% and −3.6%, respectively, when ultrasonic-assisted freezing was applied in the maximum ice crystal formation zone and the whole process. The consistency coefficient and shear resistance of wheat starch system in dough were maintained to a certain extent by applying ultrasonic in the maximum ice crystal formation zone and the whole process. The consistency coefficient of starch decreased by 19.0% and 23.3%, and the shear structure resilience increased by 4.0% and 7.2%, respectively. Compared with the frozen samples without ultrasonication, the relative crystallinity of wheat starch in the sonicated dough was reduced, and the short-range ordered structure of starch molecules was reduced to a certain extent. In summary, the application of ultrasonic field refines the ice crystals and slows down the damage to the internal structure of wheat starch in the dough during the freezing process. A comparison between the two ultrasound processes, it can be speculated that the effect of ultrasonic application in the whole process of dough-freezing is significantly better than that in the maximum ice crystal formation zone.

Stroke has a high disability rate and fatality rate. It is of great clinical significance to study the automatic recognition and segmentation of stroke lesions. Convolutional neural network can not make use of time sequence correlation of medical image data, and has the problem of low feature utilization. Therefore, a bidirectional recurrent U-Net (BIRU-Net) model was proposed for segmentation of lesions. First, a recurrent neural network is introduced to replace part of the convolutional layer in U-Net with an improved attention convolutional gate recursive unit (ACGRU), so that the segmentation model is not only suitable for small-scale annotated medical image data sets, but also has the characteristics of long-term memory. Second, a dual-channel fusion training mechanism is adopted to input the forward and reverse slice data of a single view into BIRU-Net at the same time, and realize bidirectional feature fusion in the process of model forward propagation, effectively utilizing the bidirectional dependence of slice sequence. Finally, the segmentation results of each single view are refused to effectively utilize the spatial context information of data. The experimental results of ATLAS data set show that the DSC value of the proposed method reaches 62.58%. Compared with other methods at the present stage, the proposed method can segment the lesion region more accurately.

Background and objective microRNAs play an important role in the development and biological phenotype of lung cancer. The present study was to investigate miR-367-3p level in non-small cell lung cancer (NSCLC) patients and its biological function of NSCLC cells. Methods Twenty-two patients with NSCLC (13 cases of adenocarcinoma and 9 cases of squamous carcinoma) admitted to our hospital and treated by surgery were included. During the operation, cancer tissue, paracancerous tissue and 5 mL peripheral blood were collected. Meanwhile, 22 healthy controls were selected and 5 mL peripheral blood was taken. Real-time PCR was applied to detected the expression of miR-367-3p in cancer tissues, peripheral blood of patients with NSCLC and healthy controls. miR-367-3p was detected in lung cancer cell lines (A549) and normal bronchial epithelial cells (BEAS-2B). The proliferation and invasion ability of A549 cells before and after infection were detected by MTT and Transwell assay after transfection with exogenous miR-367-3p. The downstream target gene of miR-367-3p was analyzed by bioinformatics. Zinc finger E-box binding homeobox 2 (ZEB2) was detected by Real-time PCR and Western blot. Results miR-367-3p in cancer tissues of 22 NSCLC patients was lower than corresponding normal tissues (P0.05). ZEB2 expression was positively correlated with infiltration of B lymphocytes (r=0.32, P

The general characteristics of karst collapse in Yunnan plateau is comprehensively influenced and determined by the specific geological environment, karst development, hydrogeology, hydrometeorology and human engineering activities. This article analyses these factors and its mechanism, deepen the understanding on the basic characteristics and development law of karst collapse. The karst collapse in Yunnan Plateau is sporadically distributed, showing "point" characteristics, and mainly develops in karst geological environment units such as karst faulted basin, karst trough valley (depression) land, karst platform or ancient plateau surface.The main reason is that most of the plateau is exposed bedrock mountainous area, with deep rivers, vertical karst zones and deep groundwater.In basin, valley, depression and other areas inhabited by human beings, the overburden of loose soil is thicker, the proportion of cohesive soil layer is higher, and the degree of soil consolidation is higher, except for the marginal zone.Karst development is not uniform, karst caves and tubes are developed, but the underground karst rate is not high in general, and the caves and tubes that cause karst collapse are isolated and scattered.

Network security is an important part of the national security, and network security threat intelligence work has become an important part of the network security protection.Aiming at the problems of power enterprise carrying out network security threat intelligence, such as many sources, many types, wide range, many vulnerability risks, many subordinate departments and personnel, the network security threat intelligence work plan of power enterprise was put forward.The scheme includes five aspects: information source, information research and judgment, information disposal, information platform and information performance.The evaluation method of network security vulnerabilities, information emergency disposal process and information performance evaluation method were puts forward.The preliminary application results show that the proposed scheme has important reference value for power enterprise to improve the emergency response ability of network security information and the level of network security protection ability.

Objective: In this study, Tuber liyuanum was used as the experimental material to optimize and determine the extraction process of polysaccharides, and analyze the monosaccharide components. Methods: On the basis of single factor experiment, L9(34) orthogonal experiment was used to design, optimize and determine the optimum technological conditions for extracting polysaccharides by water extraction and alcohol precipitation, and the monosaccharide components of T. liyuanum were analyzed by 1-phenyl-3-methyl-5-pyridine pre-column derivatization HPLC with oxazolinone. Results: The optimum process conditions of extracting polysaccharides from T. liyuanum were as follows: Extraction temperature was 90 ℃, extraction time was 60 min, and solid-to-liquid ratio was 1:25 g/mL. Under these conditions, the yield of polysaccharides was 10.57% ± 0.31%. The polysaccharides of T. liyuanum were mainly composed of D-glucose and a small amount of D-mannose and D-galactose. And the ratio of its substances was 1:0.023:0.006. Conclusion: The water extraction and alcohol precipitation method could obtain a higher yield of T. liyuanum polysaccharides under the optimal extraction process conditions, which was simple, stable and feasible. The determination of monosaccharides composition in T. liyuanum polysaccharides by pre-column derivatization HPLC was simple, reproducible and accurate, which could provide a theoretical basis for further research on T. liyuanum polysaccharides in pear orchards.

In order to investigate the corporate effect of vacuum mixing and freezing-thawing treatment on microstructure and quality of quick-frozen Youtiao dough and fritters, frozen Youtiao dough was prepared under the vacuum mixing (0~0.08 MPa) and freezing-thawing treatment (0~3 times). Combined analytical methods covering multiple instruments (e.g., low field nuclear magnetic resonance, scanning electron microscopy, and fourier infrared spectrum analyzer) were used to investigate the water distribution, microstructure, and secondary structure of treated frozen Youtiao dough. Meanwhile, the oil content, water content, specific volume and textural quality of Youtiao were analyzed. Results showed that freezing-thawing treatment destroyed the structure of the dough, declined the strong bonding water content of dough and α-helical content in gluten (14.80%~13.61%), resulting in the loose and disordered protein structure. However, with the increase of vacuum degree, the strong bonding water content in quick-frozen Youtiao dough gradually increased, and the ordered degree of protein network structure in dough also improved. Furthermore, freezing-thawing treatment could also decrease the volume (1.82 cm3/g~1.47 cm3/g), increase the oil content (15.08%~16.88%) and reduce the textural quality of Youtiao, while vacuum mixing could effectively decrease the oil content (15.08%~12.64%), improve volume (1.82 cm3/g~2.38 cm3/g), reduce hardness and improve other qualities of Youtiao. These results indicated that vacuum mixing could reduce the quality deterioration caused by freezing-thawing treatment by regulating the water distribution and protein structure in quick-frozen Youtiao dough. Therefore, this study can provide theoretical basis and guidance for large-scale production of quick-frozen Youtiao.

5G deterministic network is a new type of industrial communication technology vigorously promoted by the international industry.3GPP had introduced the time-sensitive communication technology to facilitate deterministic transmission.Compared with ultra-reliable and low-latency communication technology, time-sensitive communication technology further enhanced the 5G network in terms of delay jitter and time synchronization to realize the end-to-end time sensitive communication.Characteristics of time sensitive communication technology were analyzed.Based on the time-sensitive networking and 5G network converged architecture, the time-sensitive communication technology reduces the time synchronization error through the accurate time synchronization mechanism.Additionally, the scheduling enhancement mechanism was introduced to reduce the transmission delay.Furthermore, the Ethernet header compression mechanism was proposed to improve transmission efficiency.

Background and objective Malignant pleural effusion is one of the common clinical manifestations of patients with lung adenocarcinoma. Patients with pleural effusion at the initial diagnosis of lung adenocarcinoma usually indicate poor prognosis. Epidermal growth factor receptor (EGFR) mutations mainly occur in patients with lung adenocarcinoma. Patients with different mutant subtypes have different prognosis. The clinical characteristics and prognostic factors of patients with EGFR mutated lung adenocarcinoma of different molecular subtypes combined with pleural effusion at initial diagnosis are still unclear. This study was designed to explore the clinical characteristics and prognostic factors of these patients in order to provide management recommendations for them. Methods A retrospective analysis of the clinical characteristics, treatment, outcomes and progression-free survival (PFS) of first-line treatment in patients with EGFR mutated lung adenocarcinoma combined with pleural effusion at initial diagnosis admitted to Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital from January 2012 to June 2021 was performed. Pearson's chi-square test or Fisher's exact test were performed for comparison between groups. Kaplan-Meier method was performed for survival analysis and Cox proportional risk regression model was performed for multivariate analysis. Results 76 patients met the inclusion criteria in this study. The incidences of EGFR classical mutations 19del, 21L858R and non-classical mutations were 46.0%, 38.2% and 15.8%, respectively among these patients. There was no significant difference between the three mutations in terms of gender, age, presence of dyspnea at presentation, whether other distant metastases were combined, site of pleural effusion, volume of pleural effusion, presence of other combined effusions, tumor-node-metastasis (TNM) stage, presence of other gene mutations, and treatment of pleural effusion (P>0.05). In patients with EGFR classical mutations 19del or 21L858R or non-classical mutations subtype, the proportion of chemotherapy in first-line regimens were 17.1%, 20.7% and 58.3%, respectively (P=0.001); and first-line disease control rates were 94.3%, 75.9% and 50%, respectively (P=0.003); pleural effusion control rates were 94.3%, 79.3% and 66.7%, respectively (P=0.04); PFS were 287 d, 327 d and 55 d, respectively (P=0.001). Univariate analysis showed that EGFR mutation subtype, control of pleural effusion, first-line treatment agents, and first-line treatment efficacy were significantly associated with PFS (P

Background: The literature recommends that reduced dosage of CPT-11 should be applied in patients with UGT1A1 homozygous mutations, but the impact of UGT1A1 heterozygous mutations on the adverse reactions of CPT-11 is still not fully clear. Methods: A total of 107 patients with UGT1A1 heterozygous mutation or wild-type, who were treated with CPT-11 from January 2018 to September 2021 in Peking University Third Hospital, were retrospectively enrolled. The adverse reaction spectra of patients with UGT1A1*6 and UGT1A1*28 mutations were analyzed. Adverse reactions were evaluated according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) 5.0. The efficacy was evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. The genotypes of UGT1A1*6 and UGT1A1*28 were detected by digital fluorescence molecular hybridization. Results: There were 43 patients with UGT1A1*6 heterozygous mutation, 26 patients with UGT1A1*28 heterozygous mutation, 8 patients with UGT1A1*6 and UGT1A1*28 double heterozygous mutations, 61 patients with heterozygous mutation at any gene locus of UGT1A1*6 and UGT1A1*28. Logistic regression analysis showed that the presence or absence of vomiting (P=0.013) and mucositis (P=0.005) was significantly correlated with heterozygous mutation of UGT1A1*28, and the severity of vomiting (P

In order to enrich the functionalities of existing learned multidimensional indexes and improve the efficiency， the dynamic data segmentation algorithm DDSA was proposed， which could preserve the data distribution characteristics.A hybrid spatial index was constructed by combining the QuadTree and Z-order curve （QML）.The range query algorithm were designed and KNN query algorithm respectively.The proposed index allowed flexible fast queries and updates with preserving the characteristics of data distribution.Experimental results show that QML optimizes the query efficiency on the premise of achieving rich functionalities， and the time complexity of data update is O（1）.Compared with R*-tree， the storage consumption of QML is reduced by about 33%， and the update efficiency is improved by 40%～80% .The query efficiency is similar to the optimal tree Index.

Traditional small module spiral bevel gear milling needs to use a large number of cutting fluid，which will not only cause environmental pollution，but also increase production costs，the new technology of high speed dry cutting does not use cutting fluid，which reduces environmental pollution and improves production efficiency. Based on the theory of bevel cutting，combining the equivalent plane method of oblique cutting with the machining theory of spiral bevel gear，the high speed dry cutting technology of small module spiral bevel gear is studied. Aiming at the characteristics of high speed dry cutting technology of small module spiral bevel gear，the thermal mechanical coupling model of bevel cutting is established，and the influence of different process conditions on cutting force is simulated and analyzed by using Abaqus finite element software. The cemented carbide is selected as the tool material，and the high speed dry cutting technology process of small modulus spiral bevel gear is discussed. The feasibility of this technology is verified by machining test. The research provides a reference basis for the implementation of this technology.

The vulnerability detection model of Android application based on learning lacks semantic features.The extracted features contain noise data unrelated to vulnerabilities, which leads to the false positive of vulnerability detection model.A feature extraction method based on code information slice (CIS) was proposed.Compared with the abstract syntax tree (AST) feature method, the proposed method could extract the variable information directly related to vulnerabilities more accurately and avoid containing too much noise data.It contained semantic information of vulnerabilities.Based on CIS and BI-LSTM with attention mechanism, a context-aware Android application vulnerability detection model VulDGArcher was proposed.For the problem that the Android vulnerability data set was not easy to obtain, a data set containing 41 812 code fragments including the implicit Intent security vulnerability and the bypass PendingIntent permission audit vulnerability was built.There were 16 218 code fragments of vulnerability.On this data set, VulDGArcher’s detection accuracy can reach 96%, which is higher than the deep learning vulnerability detection model based on AST features and APP source code features.

There are a large number of earthquake networks under the management of cities and counties，which have made historical contributions to reducing earthquake disasters and promoting the development of earthquake prevention and disaster reduction. In recent years，the development of earthquake networks managed by cities and counties lags behind the development level of the same industry，exposing problems such as unclear positioning，low efficiency and cognitive deviation. Taking Yangzhou Earthquake Networks Center as an example，the advantages and disadvantages before and after the institutional reform in 2019 are summarized and compared. The objectives and tasks of the modernization development of earthquake prevention and disaster reduction are combined. In order to promote the development of work，this paper puts forward suggestions from four aspects：self-orientation，work implementation，coordination of multiple relationships，scientific understanding of reform and development.

The processing of traditional small module spiral bevel gears is duplex spread-blade method， on the specialized gear milling machine. The gear and pinion are generated normally by the method of duplex， which has high processing efficiency， but the meshing quality on their surface is controlled in difficulty， which fundamentally limits the improvement of its transmission performance. For the bad contact zone of spiral bevel gears with duplex processing， the gear machining parameters are modified and optimized by using the TCA technology， thus the contact condition and meshing quality of the gear pair are improved. This can not only ensure the production efficiency of common modulus spiral bevel gear which is machined by duplex method， but also improve the meshing quality of the gear pair.

The analysis method of tooth flank mismatch meshing is studied for the spiral bevel gear of automobile drive axle. Firstly，the mathematical model of tilt cutting method is established，and the cradle angle is derived according to the meshing equation，so the tooth flank equation can be simplified. Secondly，the gear meshing angle is derived based on the equality unit normal vector of the gear meshing mathematical model（TCA），so the TCA solving equations can be simplified. On this basis，the tooth flank mismatch values are calculated by calculating the deviations between the pinion actual tooth flank and pinion reference tooth flank which is fully conjugated with the gear，and the tooth flank Ease off topology is constructed by graphical expression. Compared with the traditional tooth flank meshing analysis method，the proposed method not only reduces the number of equations，but also makes the algorithm more stable. The Ease off topology can visually display the whole tooth flank mesh state and improve the current TCA output.

Taking the construction of Changdu earthquake intensity quick report system in Tibet as an example，and comparing with the experience of foreign countries，this paper discusses the related problems from aspects of network density，communication transmission and construction cost，which can provide reference for the construction of other regions’earthquake intensity quick report system.

Aiming at the dual duplex spread blade method for cutting spiral bevel gears, the midpoint of the tooth space of pinion is treated as the reference point for the bilateral modification tooth surfaces. The target tooth surface is constructed to meet with the meshing performance by predetermining of the meshing parameters. The mathematical model and constraint function of the target tooth surface errors based on the optimization of machining tool setting are constructed. The nonlinear constrained optimization function is used to derive the machining parameters of the gear. The optimized method is verified by tooth contact analysis and finite element contact analysis. The simulation results show that the meshing performance meets the expected requirements after the tooth surface modification.

In order to solve the difficulty in climbing stairs for the elderly and disabled， a new type of combined climbing wheelchair with planet wheel track is proposed. The combined structure with planet wheel track is used to achieve the function of stair-climbing and obstacle-surmounting. The wheelchair is driven by a motor， the planet wheel adopts chain drive to climb stairs and drive on the flat ground. Combined with the track device， this structure effectively reduces the vibration of the wheelchair with planet chair and improves the obstacle-surmounting ability of traditional wheelchair. On the basis of comparing the structural characteristics of the existing climbing wheelchair， the scheme of designing a new type wheelchair robot with a combination of with the planet wheel and track is introduced， and its operating principle is analyzed， a mathematical model is established to make a kinematics and dynamics analysis on the stair-climbing process. The results show that， the wheelchairs can safely climb most stairs. The structure design of the wheelchair is reasonable， the combination of climbing stairs and moving on the flat ground is realized.

The effective processing and deep mining analysis of data can provide manufacturers with more effective production scheduling,equipment management and other strategies to affect production yield and efficiency.The processing methods and technologies of multi-source heterogeneous data in the manufacturing process were systematically reviewed.Firstly,the multi-source heterogeneous data content and classification in the manufacturing process was clarified.Secondly,the data processing methods and techniques applied in various stages of data collection,data integration and data analysis in the multi-source heterogeneous data processing were described.And the advantages and disadvantages of various techniques and their applications were analyzed.Finally,the multi-source heterogeneous data processing methods and techniques in the manufacturing process were summarized.And the challenges and development trends were pointed out.