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Objective: To explore the predictive value of serum hyperhomocysteine(Hcy), uric acid(UA) and cystatin C(Cyst-C)levels in the occurrence of carotid atherosclerosis in patients with H type hypertension. Methods: A total of 163 patients with H type hypertension, who were admitted to Chongqing Zhongshan Hospital from May 2014 to May 2015, were chosen as research subjects and divided into normal carotid intima-media thickness(c IMT) group(n=51), thickened c IMT group(n=54) and carotid artery plaque group(n=58) according to the difference of c IMT. The gender, age, serum Hcy, Cyst-C, UA, blood glucose(GLU), blood lipid, blood urea nitrogen(Bun) and serum creatinine(Scr) levels among the three groups are detected and compared, and their correlation with c IMT was analyzed. The influencing factors of carotid atherosclerosis were analyzed by logistic regression analysis. Results: There were significant differences in the HDL-C, Hcy, Cyst-C and UA levels among the three groups(P<0.05). c IMT was positively correlated with the serum Hcy, Cyst-C and UA(r=0.23, 0.32, 0.30; P<0.05), negatively correlated with HDL-C(r=-0.410, P<0.05). Logistic regression analysis showed that the levels of Hcy, Cyst-C and UA were the risk factors of carotid atherosclerosis(OR=1.203, 6.395, 1.023; P<0.05).Conclusion: Serum Hcy, Cyst-C and UA levels are positively correlated with c IMT in the patients with H type hypertension. They are the independent risk factors leading to carotid atherosclerosis,which can be used to predict the occurrence and development of atherosclerosis in the early stage in clinic. [ABSTRACT FROM AUTHOR]