1. [Detection of Borna disease virus-p24 specific antibody in the sera of schizophrenic patients of China by means of Western-blot].
- Author
-
Yang AY, Zhang FM, Li JH, Li GM, Ma PL, Gu HX, and Ikuta K
- Subjects
- Blotting, Western, Humans, Antibodies, Viral blood, Borna disease virus isolation & purification, Schizophrenia virology, Viral Proteins immunology
- Abstract
Background: To investigate whether Borna disease virus (BDV) infection is related to the schizophrenic patients from China., Methods: A reliable Western-blot method for detection of BDV-p24 antibody was established by adjusting the reaction conditions of BDV-p24 recombinant protein and specific antibodies. The sera of schizophrenic patients and normal controls from Heilongjiang Province were screened for specific BDV-p24 antibody by this method, and the BDV-p24 antibody positive sera were confirmed by the Western-blot method with sera-GST protein absorption., Results: Ten of 116 (8.6%) schizophrenic patients were found to be positive for BDV-p24 specific antibody, while no BDV-p24 specific antibody was found in sera of normal controls., Conclusions: The results demonstrate that the Borna disease virus infection also exists in China, and the infection is possibly associated with schizophrenia in some way.
- Published
- 2003