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The experiment aimed to investigate the influence of rosemary extract on oxidative stress in weaned piglets. A total of 144 'Duroc x Landrace x Yorkshire' ternary hybrid piglets weighing about 8.0 kg and weaned at 26 days of age were randomly divided into four groups, with six replicates in each group and six piglets (half in male and female) in each replicate. The piglets in the control group were fed with a basal diet, and experimental groups (200, 400, 600 mg/kg RE group) added an additional 200, 400, and 600 mg/kg rosemary extract (RE) to the basal diet, respectively. The test lasted for 24 d. The results showed that compared with the control group, the addition of 200 mg/kg RE could significantly increase the average daily gain and average daily feed intake of weaned piglets (P<0.05), and significantly reduce the feed to gain ratio (P<0.05). On the 10th day, compared with the control group, the serum GSH-Px and SOD activity of weaned piglets in the experimental groups were significantly increased (P<0.05), CAT activity in serum of weaned piglets in 600 mg/kg RE group was significantly increased (P<0.05), and the content of MDA in the 600 mg/kg RE group was decreased significantly (P<0.05). On the 10th day, the serum levels of IGF-I and Ghrelin in weaned piglets in the 200 mg/kg RE group were significantly increased (P<0.05), and the GH levels in the serum of weaned piglets in 400 mg/kg RE group were significantly increased (P<0.05). On the 24th day, the serum levels of IGF-I and GH in the weaned piglets in the 200 mg/kg group were significantly increased (P<0.05), and the serum levels of IGF-I in the weaned piglets in the 600 mg/kg group were significantly increased (P<0.05). The study indicates that the addition of RE to the diet can alleviate the oxidative stress caused by early weaning of piglets, promote the growth and development of weaned piglets, and enhance the antioxidant ability of piglets, and the suitable amount of addition is 200 mg/kg. [ABSTRACT FROM AUTHOR]