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ObjectiveThis paper analyzes and models the core logic of a strike chain in terms of time sensitivity, reconfiguration and coverage, thereby providing model and method support for improving the dynamic management ability of naval combat resources under confrontation conditions. MethodsFirst, the typical combat platforms and elements related to the cross-domain cooperative combat of naval battlefields, such as escort ships, UAVs and unmanned boats, are abstracted into four types of resource nodes, namely detection, processing, decision-making and strike. Next, taking the shortest delay as the goal and considering constraints such as wide battlespace, low transmission rate between nodes and limited communication distance, the dynamic integration optimization mathematical model of the strike chain is established. A typical air defense scenario is then designed to demonstrate the shortest delay analysis of the strike chain and the destruction reconstruction analysis under the absence or attack of nodes, and quantitatively describe the changes of the shortest delay and sector coverage index of the reorganized strike chain under countermeasure conditions. Finally, based on a typical combat example of a Ukrainian unmanned cluster attack on the Black Sea Fleet, the ability of the fleet to resist the attack is analyzed on basis of the strike chain model. ResultsThe simulation results show that the model can be used to generate multiple strike chains with the shortest delays, and the responsibility division of each strike chain can be optimized, forming a multi-target killing network at sea. The destruction reconstruction of the strike chain often needs to pay such costs as increased delay and decreased sector coverage. The model can also be used to test anti-saturation attack ability under different formations.ConclusionsThis paper studies and validates the feasibility of analyzing the naval warfare system based on the strike chain model, and can provide theoretical model support for the subsequent design of future naval joint combat systems oriented to the killing network.

As a highly prevalent disease worldwide, diabetes kidney disease （DKD） is a common complication of diabetes and a major cause of end-stage renal disease （ESRD）. One clinical symptom of DKD is persistent proteinuria with or without a gradual decrease in glomerular filtration rate （GFR）. Urinary microalbumin is currently recognized as a marker of early renal injury. However, it has some limitations. Kidney biopsy is a gold diagnostic standard for DKD. Yet its wider applications are restricted by its invasive nature. Therefore actively seeking non-invasive and reliable diagnostic modalities for DKD is of great significance. This review summarized the latest researches of early non-invasive diagnosis of DKD and provided valuable references for an early diagnosis of DKD in clinical practices.

Due to the concentrated carbon emission sources and the enormous carbon emissions in the Ningxia Hui Autonomous, it is necessary to evaluate carbon sequestration potential to support future CCUS planning and major demonstrations. Based on the basic geological conditions for carbon sequestration in Ningxia, this study used the volumetric method of the US Department of Energy (US-DOE) to assess the geological potential for deep saline aquifer sequestration in Ningxia. The results show that the predicted geological potential of carbon sequestration in the deep saline aquifers in Ningxia is approximately 86.742 billion tons, with the predicted technical capacity of about 42.334 billion tons. The main reservoirs are concentrated in the Yanchi area in eastern Ningxia and the Liupan Mountain Basin. A preliminary evaluation of the suitability of saline aquifer sequestration in Ningxia was conducted by considering many factors such as the overall sequestration potential, cap rock integrity, geological stability, and socio-environmental risks. The results indicate that the Yanchi area in eastern Ningxia has favorable reservoir and cap rock conditions, stable structures, and low population density, making it a potential region for CO2 sequestration in Ningxia.

Background Gastrointestinal dysfunction is a very common complication in peritoneal dialysis patients, which not only seriously affects the appetite and mood of patients, but also induces malnutrition, dehydration, electrolyte disorders, or systemic inflammatory reactions, and even leads to a decrease in the effectiveness of peritoneal dialysis, thus increasing the difficulty of medical treatment and lowering the patients' standard of living. Objective To analyse the clinical characteristics and influencing factors of patients with peritoneal dialysis-associated gastrointestinal dysfunction, and provide reference for the clinical diagnosis and treatment of peritoneal dialysis-associated gastrointestinal dysfunction. Methods A retrospective study was conducted to select 304 uremic patients who underwent continuous ambulatory peritoneal dialysis in the Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from 2019-09-01 to 2021-09-01. The patients were divided into the gastrointestinal dysfunction group and non-gastrointestinal dysfunction according to the combination of gastrointestinal dysfunction. General data, comorbidities, laboratory test indexes, and dialysis adequacy-related indexes of the two groups of patients were collected and compared. SPSS 23.0 software was used to statistically analyze the clinical data, the clinical characteristics of peritoneal dialysis-associated gastrointestinal dysfunction, and multivariate Logistic regression analysis was used to explore the factors influencing the occurrence of peritoneal dialysis-associated gastrointestinal dysfunction in patients with uremia. Results A total of 304 peritoneal dialysis patients were included, of which 189 (62.2%) were in the gastrointestinal dysfunction group, with the median age of 62 (52, 67) years. The differences in age, proportions of primary diabetic nephropathy and combined hypertension and coronary artery disease between the two groups were statistically significant (P

ObjectiveTo explore the intervention effects of different social media platforms on improving the knowledge of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) diagnosis and treatment among HIV-positive men who have sex with men (MSM). MethodsA total of 288 HIV-positive MSM were recruited at the Shandong Provincial Public Health Clinical Center from October to December 2020, and according to their preference, the MSM were divided into three groups to receive information on the knowledge and practice of HIV/AIDS diagnosis and treatment via short message service (SMS), WeChat, and the combination of WeChat and QQ group in six months. The generalized estimating equation used to analyze and compare the intervention effects of the interventions via different social media on the overall knowledge score of HIV/AIDS diagnosis and treatment among the all and subgroups of the participants. ResultsThe mean age of the participants was 34.67 ± 9.22 years. Six-month follow-up showed that the total score of HIV/AIDS diagnosis and treatment knowledge in the WeChat intervention group was 0.38 points higher than that in the SMS intervention group (P = 0.01), and there was no significant difference between the results of the other intervention groups (P > 0.05); in the subgroup with high school education and below, WeChat intervention (P = 0.018), WeChat and QQ group intervention (P = 0.002) were better than SMS intervention in improving the total score of AIDS diagnosis and treatment knowledge. ConclusionCompared with SMS intervention, WeChat intervention significantly improved the HIV/AIDS diagnosis and treatment knowledge score of HIV-positive MSM, and WeChat can be used as the main media for HIV-positive MSM to popularize HIV/AIDS knowledge in the future.

为获得优质的核桃蛋白血管紧张素转化酶（ACE）抑制肽的制备原料及优化其制备工艺，采用连续提取法从脱脂核桃粕中依次分离出清蛋白、球蛋白、醇溶蛋白、谷蛋白-1和谷蛋白-2 5种组分蛋白，测定5种组分蛋白的占比及ACE抑制率，以ACE抑制率最大的组分蛋白作为原料采用酶解法制备ACE抑制肽，在筛选出最适酶解用酶基础上，采用单因素试验与响应面试验优化酶解制备核桃蛋白ACE抑制肽的工艺。结果表明：5种组分蛋白中谷蛋白-1占比仅次于谷蛋白-2，且其ACE抑制率最高，以核桃谷蛋白-1为原料，在筛选出胃蛋白酶作为酶解用酶基础上，经工艺优化得到最优的酶解法制备核桃谷蛋白-1 ACE抑制肽的工艺条件为酶解温度46 ℃、酶解时间6 h、酶用量4.2%（以底物质量计）、酶解pH 1.6，在该条件下所得核桃谷蛋白-1 酶解液的ACE抑制率为（50.08±2.34）%。因此，核桃谷蛋白-1经胃蛋白酶酶解可生产ACE抑制活性较高的核桃多肽。In order to obtain high-quality raw materials for the preparation of angiotensin converting enzyme (ACE) inhibitory peptide from walnut protein and optimize its preparation process, five component proteins including albumin, globulin, prolamin, glutelin-1 and glutelin-2 were separated from defatted walnut meal using continuous extraction method in turn. The proportion and ACE inhibition rates of the five component proteins were determined.The component protein with the largest ACE inhibition rate was used as raw material to prepare ACE inhibitory peptide by enzymatic hydrolysis. On the basis of selecting the optimal enzyme, the enzymatic conditions for the preparation of walnut protein ACE inhibitory peptide were optimized by single factor experiment combined with response surface methodology.The results showed that the proportion of glutelin-1 in the five component proteins was second only to glutelin-2, and its ACE inhibition rate was the highest. With walnut glutelin-1 as raw material and pepsin as enzyme, the optimal enzymatic hydrolysis preparation conditions of walnut glutelin-1 ACE inhibitory peptide were obtained as follows: enzymolysis temperature 46 ℃, enzymolysis time 6 h, enzyme dosage 4.2%(based on the mass of substrate), and enzymolysis pH 1.6. The ACE inhibition rate of the enzymatic hydrolysate obtained under the optimal conditions was （50.08±2.34）%. Enzymatic hydrolysis of walnut glutelin-1 by pepsin can produce walnut polypeptides with higher ACE inhibitory activity.

Objective To explore the interaction between microRNA-23 （miR-23） and mitochondrial fission protein 1 （FIS1） in human kidney-2 （HK-2） cells and examine the effect of miR-23 on inflammatory response and oxidative stress by targeting FIS1. Methods HK-2 cells were cultured in vitro and induced by lipopolysaccharide （LPS） for modeling of sepsis. Dual luciferase reporter assay was utilized for verifying the interaction between miR-23 and FIS1. HK-2 cells were randomized into groups of miR-23 mimic/inhibitor and eukaryotic expression vector and small interfering RNA of FIS1 alone or in a combination. Cell proliferation was detected by cell counting kit-8 （CCK-8） assay and apoptosis and reactive oxygen species （ROS） were examined by flow cytometry. Malondialdehyde （MDA） was detected by MDA kit and the levels of tumor necrosis factor t （TNF-α）, interleukin （IL）-1β and IL-6/10 were measured by enzyme-linked immunosorbent assay（ELISA）. ResultsThe miR-23 mRNA in HK-2 cells induced by LPS was (0.60±0.12) folds that of control group(P

Vegetation restoration is crucial for improving the ecological environment of mining areas, which could promote the development of reconstructed soil, thus regulating biogeochemical cycles, and exerting ecosystem functions. Therefore, it is essential and necessary to conduct in-depth research on the impact of vegetation restoration on soil microbial communities in open-pit mining areas. In this study, surface soil samples were collected from six typical reclamation plots, including bare land (CK), Medicago sativa (GL), Hippophae rhamnoides (BL), Pinus tabulaeformis (CF), Populus tomentosa (BF), and Populus tomentosa + Pinus tabulaeformis (MF), located in the eastern waste dump of Heidaigou mining area of Zhungeer Banner, Inner Mongolia. High throughput sequencing, co-occurrence networks, and correlation analysis were used to explore the influential mechanism of vegetation types on soil abundant, rare bacterial and fungal community structural composition and diversity. Results showed that ① there were significant differences in the effects of different vegetation restoration types on soil physicochemical properties and enzyme activity (P

Breast cancer is the most common malignant tumor in women and its early detection is decisive. Breast imaging plays an important role in early detection of breast cancer as well as monitoring and evaluation during treatment, but manual detection of medical images is usually time-consuming and labor-intensive. Recently, deep learning algorithms have made significant progress in early breast cancer diagnosis. By combing the relevant literature in recent years, a systematic review of the application of deep learning techniques in breast cancer diagnosis with different imaging modalities is conducted, aiming to provide a reference for in-depth research on deep learning-based breast cancer diagnosis. Firstly, four breast cancer imaging modalities, namely mammography, ultrasonography, magnetic resonance imaging and positron emission tomography, are outlined and briefly compared, and the public datasets corresponding to multiple imaging modalities are listed. Focusing on the different tasks (lesion detection, segmentation and classification) of deep learning architectures based on the above four different imaging modalities, a systematic review of the algorithms is conducted, and the performance of each algorithm, improvement ideas, and their advantages and disadvantages are compared and analyzed. Finally, the problems of the existing techniques are analyzed and the future development direction is prospected with respect to the limitations of the current work.

Although the reclamation activity could effectively promote the ecological service function of mining areas, the microbiological mechanism of functional reconstruction of reclaimed soil is still unclear. Clarifying how reclamation affects the characteristics, assembly mechanisms, and carbon sequestration functions of soil bacterial communities, is crucial for reshaping the ecological self-sustaining capacity of mining areas. To shed light on this purpose, combined with zero model analysis, MiSeq high-throughput sequencing and qPCR SmartChip technologies were used to explore the assembly processes and carbon sequestration functional variations of soil bacterial community in Dongtan mine area at four reclamation years (reclaimed 9 a, 12 a, 15 a, and 18 a). The results showed that: ① Reclamation activity and time presented significant impacts on soil physicochemical properties and enzyme activities. Soil pH, ammonium nitrogen (AN), catalase (CAT), and alkaline phosphatase (PO) showed the significant increasing trends with the incremental reclamation time (P

In order to explore the corrosion mechanism of dual-phase X80 pipeline steel in the coastal soil simulation solution environment, the stress corrosion and electrochemical corrosion behavior of dual-phase X80 pipeline steel under different applied potentials (-750,-900 and -1 050 mV vs. saturated calomel electrode (SCE)) were studied by using polarization curve, slow strain rate tensile test (SSRT) and electrochemical impedance spectroscopy (EIS). The results show that dual-phase X80 pipeline steel is the most sensitive to stress corrosion (SCC) under -1 050 mV potential. SSRT exhibits brittle fracture, with circular or elliptical pits visible on the fracture at the ferrite region. This is due to the diffusion of hydrogen atoms generated by excessive cathodic reaction into the steel and aggregation at the boundaries of ferrite grains. When the hydrogen pressure generated by hydrogen gas precipitation exceeds the material strength, circular pits are generated and become elliptical under tensile stress. Meanwhile, EIS of sample, under-1 050 mV has the smallest simulated resistance, indicatingits worst corrosion resistance. The external potential of-750 mV can provide some electrochemical protection, yet it is not enough to reduce the stress corrosion of dual-phase X80 pipeline steel. The external potential of-900 mV can effectively inhibit the anodic dissolution of X80 pipeline steel. The strength and ductility of X80 pipeline steel after SSRT under-900 mV are both higher than those without external potential, exhibiting ductile fracture characteristics . Its EIS simulationresistances are the highest.Therefore, the optimal cathodic protection potential of dual-phase X80 pipeline steel in simulated coastal soil environment is about -900 mV vs. SCE. The study on the stress corrosion behavior of the dual-phase X80 pipeline steel in the simulated coastal soil environment can provide a theoretical basis for its safe service and provide a reference for corrosion suppression and protection in practical application.

The fertility of reclaimed soil in the Huang-Huai plain mining area is low, which is closely related to nutrient cycling. However, the microbiological mechanism of the effect of reclamation on soil nutrient cycling is still unclear. A total of 65 topsoil samples were collected from 4 reclamation areas and 1 control area in Dongtan mining area located in Zoucheng City, Shandong Province. High-throughput sequencing, PICRUSt2 and FUNGuild analysis tools were used to explore the effects of reclamation on soil microbial community structure and function, as well as unravel the environmental driving mechanism of microflora succession. The results showed that ① soil physical and chemical properties, and enzyme activities were significantly affected by reclamation (P

Anthocyanins are the main color substances in fruit juice beverages. However, they are susceptible to degradation and fading, particularly in the presence of ascorbic acid (VC), which harms the quality of fruit juice beverages. In this study, the cyanidin-3-O-glucoside (C3G)-VC simulation system was used to examine the effect of gelatin on the stability of C3G during storage. The interactions between gelatin and VC, gelatin and C3G were investigated, and the corresponding mechanisms were elucidated using fluorescence spectra and molecular docking. Additionally, the effect of gelatin on the stability of C3G in the simulation system without VC was also examined. The results demonstrated that gelatin could significantly improve the stability of C3G under coexisting VC, as the half-life of C3G increased from 121 h to 191 h when the mass concentration of gelatin in the system was 0.5 g/L. However, gelatin could not improve the stability of C3G in the absence of VC. Fluorescence measurements demonstrated that both C3G and VC could effectively quench the intrinsic fluorescence of gelatin via static quenching. Moreover, the binding constants between C3G and gelatin were significantly greater than those between VC and gelatin (105 vs 104), indicating that gelatin would preferentially bind to C3G in the presence of all three. In addition, molecular docking also confirmed that the interaction between C3G and gelatin was stronger than the interaction between VC and gelatin, and the interaction forces were proved to be hydrogen bonding and hydrophobic interactions. Therefore, it is hypothesized that gelatin competes with VC to bind C3G and form a complex, reducing the accessibility of VC to C3G and enhancing the stability of C3G.

The serious water pollution of coal mining subsidence areas in the eastern plains, greatly restricted the wetland self-purification and the formation of carbon sink functions. Therefore, this study starts from the causes of hydrops pollution in the coal mining subsidence areas in eastern plain, to elaborate the practical demands for collaborative remediation of pollution reduction and carbon sequestration. Meanwhile, the study provides a fascinating insight into the key processes and carbon sink formation mechanism of new formed wetland for pollution reduction and carbon sequestration, and estimate the potential of collaborative remediation, as well as put forward the adaptive managerial approach and crucial technical system for collaborative remediation. The results show that: ① Complex water supply, diverse pollution sources, and unstable ecosystem transformation are the primary causes of pollution in newborn wetlands in the eastern plain mining areas. The collaborative remediation of pollution reduction and carbon fixation can be achieved during the procedure of nitrogen, phosphorus, and organic matter degradation, as well as heavy metal detachment. The essential processes such as photosynthetic carbon fixation, carbon distribution, carbon deposition, and carbon loss, affect the carbon sink in the newly formed wetlands. ② The carbon pool stability of newly formed wetland shows significant relationships with plant root exudates, plant dead residues, wetland hydrological processes, active organic carbon components, and microbial community structure. ③ The existing carbon sink potential of the newly formed wetland in the eastern mining subsidence areas is about 4.43×106 t/a, which could reach 3.27×107 t/a up to 2060. After artificial restoration, the remediation capacity nitrogen and phosphorus pollution of newly formed wetlands can be elevated by 32.7 and 42.5 times, respectively. ④ Establishing the standing navigation mark of resources and protection, and the adaptive management strategies for synergistic and dynamic adjustment of pollution control and carbon fixation effects and schemes, is an important guarantee for implementing coordinated remediation of carbon sequestration and pollution reduction in the eastern coal mining subsidence plain. ⑤ In the future, it is necessary to gradually form a key technology system for enhancing microbial restoration of environmental materials, screening of advantageous vegetation and/or functional bacteria, and targeted proliferation of carbon fixing microorganisms, providing scientific support for ecological restoration, farmland protection, and high-quality development in coal mining subsidence areas of the eastern plain, China.

The influence of the location and the flux of the exhaust outlet on the supersonic aircraft by CFD method was studied. The optimum location was confirmed, and the research of the influence of angle of attack on exhaust effects was further carried out. The results show that: 1) the main stream has strong interference with the gas discharged by the turbopump, and the separation zone on the aircraft surface increases with the increase of the exhaust volume, resulting in drag increase and lift decrease. 2)the exhaust on the upper and lower surfaces can lead to drag increase, and the drag on the lower surface is larger than that on the upper surface under the same exhaust volume due to the upwind conditions; 3) the exhaust position should be set on the upper surface in order to reduce the drag when the aircraft is at the positive angle of attack; 4) when exhausting on the upper surface, the drag increases gradually with the increase of the angle of attack, but the difference from the reference state decreases gradually with the increase of the angle of attack.

Objective: To analyze the clinical and laboratory features of patients with acute tubulointerstitial nephritis (ATIN) and its differential diagnosis with acute tubular necrosis (ATN). Methods: From January 2009 to December 2018, patients with ATIN or ATN confirmed by renal biopsy in the Department of Nephrology, Ruijin Hospital ，Shanghai Jiao Tong Universtiy School of Medicine were included. The clinical manifestations and laboratory examination data were collected and analyzed comparatively. Results: During the period, there were 5 537 patients receiving renal biopsy,inclu-ding 135 ATIN cases [2.4% (135/5 537)] and 109 ATN [2.0%(109/5 537)].ATIN accounted for 21.4% (135/630) of the acute kidney disease (AKD) patients. The median age of ATIN patients was 53 years old and the female proportion was 57.0%. Main clinical manifestations of ATIN included fever, rash and arthralgia. Infection, and medicine use and toxic exposure were common inducements of ATIN. Compared with the ATN group, ATIN patients had higher female proportion (57.0% vs 33.9%) and lower BMI (22.9±3.6 vs 24.6±3.9, P

In order to compare the corrosion characteristics of X70 pipeline steel in acidic (pH=3) and near neutral (pH=77) simulated seawater solutions, the corrosion behaviors of X70 pipeline steel in simulated seawater solutions were studied by polarization curve, electrochemical impedance spectroscopy (EIS) and corrosion weight loss experiment. The results show that the corrosion weight loss of X70 pipeline steel immersed in acidic solution for 168 h is about 16 times as much as that in near neutral simulated seawater solution. Most of the surfaces are uniformly corroded, and corrosion circles centered on inclusions are formed locally. With the prolongation of immersion time, the radius of capacitive reactance arc and |Z|[BFQB] are both increased with adsorption first and then weak diffusion occuring. Rct increases and the corrosion rate decreases. A thick corrosion product film is formed in the near neutral simulated seawater solution. The chloride ions are aggregated and destroyed the corrosion product film. Tiny corrosion pits form and locally aggregate to induce large pits. The charge transfer resistance decreases, the corrosion rate increases and then tends to be stable. X70 pipeline steel is active in the simulated seawater solution. Compared with that in the acidic seawater solution, the Ecorr of the steel in the near neutral simulated solution moves positively by 137 mV, and icorr is about 0047 times of that in the acidic seawater solution. The corrosion laws of X70 pipeline steel in acidic and neutral simulated seawater solutions can provide theoretical support for its application in corrosion control of submarine pipelines, which is of great significance for its safe service.

Vegetation restoration is an important indicator of ecosystem health in a mining area. Understanding the impact of vegetation restoration on the characteristics and assembly process of soil microbial community is very important to explore the resilience and self-sustaining mechanism of the restored ecosystem in a mining area. Therefore, this study uses MiSeq high-throughput sequencing and zero model to detect the composition of soil microbial communities, the characteristics of molecular ecological network, the key flora and its assembly mechanism in the shrubs (BL), coniferous forests (CF), broad-leaved forests (BF), mixed forests (MF), that have been reclaimed for 18 years in Antaibao open-pit mining dump, and the control plots (CK, undisturbed surrounding poplar forests that have continued to grow for more than 30 years) in Pingshuo, Loess Plateau. The results show that: ① The effects of different vegetation restoration types on the bacterial community α-diversity are significant (P < 0.05). Compared with CK, the Sobs and Shannon index of MF and CF have increased by 35.29%, 3.50% and 25.18%, 1.05%, respectively, whereas there is no significant difference in the α-diversity of fungal community among different vegetation restoration types. ② Actinobacteria, Chloroflexi, Proteobacteria and Acidobacteria dominate in the bacterial community, and the first two dominant phylum are significantly higher than CK, while the latter two are opposite (P < 0.05). Ascomycota and Basidiomycota are the dominant fungi in the fungal community. The former is significantly higher than CK, while the latter is opposite (P < 0.05). ③ The stochastic process dominates the construction process of the soil bacterial community. In addition to the MF soil fungal community dominated by deterministic process, other fungal communities are also dominated by a stochastic process. However, no matter which type of vegetation is restored, the dominant role of the randomness process on the assembly of the bacterial community is much higher than that of the fungal community. Moreover, Proteobacteria and Acidobacteria are key taxa of the bacterial network, while Mortierellales, Thelebolales, Chaetothyriales, and Hypocreales are the key taxa of the fungal network. Vegetation restoration affects microbial community diversity, BL, CF, and MF increase the stability of the bacterial network, and MF makes fungal network more complex. The soil bacterial assembly process is dominated by stochastic processes, except for MF, and the fungal assembly process is also dominated by stochastic processes.

γ-Al2O3 is an enormously important industrial material, especially used as catalysts, catalyst supports, and adsorbents due to its attractive structural, surface, and dielectric properties. Particularly, catalytic reduction of pollutants such as nitric oxide, as well as oxidation of hydrocarbons, is accomplished with precious metals such as platinum or palladium dispersed on the γ-Al2O3 surface. γ-Al2O3 loaded with precious metals has an excellent catalytic degradation ability of organic matter and is widely used to treat exhaust gas from stationary and mobile sources. High-temperature sintering is a major cause of catalyst deactivation. For example, at higher treatment temperatures (>800 ℃), γ-Al2O3 transforms into δ-Al2O3 and θ-Al2O3, decreasing in surface area and a change in dielectric properties. Additionally, in the reaction environment, supported metal nanoparticles grow in size, leading to the loss of catalyst activity. How to improve the anti-sintering performance of catalysts is a particular concern of this field. This review analyzes the reason and mechanism of the high-temperature sintering of γ-Al2O3 loaded with precious metal. A high temperature leads to Ostwald ripening and particle migration, coalescence of precious metals, and phase transformation of γ-Al2O3, reducing the specific surface area and activity of the catalyst. On this basis, the approaches for improving the high-temperature thermal stability of catalysts were reviewed and sorted out from three aspects, namely, precious metals, supports, and the interaction between them. First, the focus is on precious metal modification, carrier modification, and changing the interaction between them to improve thermal stability. Additionally, other methods, such as the confinement method and crystal plane control, are thoroughly examined and explained. These strategies provide new insights into catalyst design. Finally, the developmental trends of γ-Al2O3-based oxidation catalysts are broadly forecasted.

In order to aovid peri-implantitis，Ti-ZnO nanocomposite coatings were prepared on the surface of pure Ti slices by reactive magnetron sputtering.The effects of nano-ZnO content on the microstructure and antibacterial performance of the coatings were studied by means of changing the splicing ratio of Ti target and ZnO target.The microstructure，roughness and wettability of the samples were characterized and measured by scanning electron microscopy (SEM)，X-ray diffraction (XRD)，atomic force microscopy (AFM) and JC2000C1 interfacial tension tester.In addition，the release of Zn ions from the coatings was measured by inductively coupled plasma-mass spectrometry (ICP-MS)，the cytotoxicity of the coatings was tested by CCK-8 method，and the antibacterial performance of the coatings was evaluated by plate colony counting method.Results showed that when the ratio of Ti target to ZnO target was 95 ∶5，the nano-ZnO content in Ti-ZnO coating was the highest，the roughness and contact angle with liquid phase of the coating reached the maximum values of 0.547 nm and 101.25° respectively，the coating had no cytotoxicity and met the standards for biosafety materials，and the antibacterial performance of the coating was the best with an antibacterial rate up to 91.05%.

In this study, a covalent complex between tamarind seed globulin (TSG) and epigallocatechin-3-gallate (EGCG) was prepared by alkali treatment. UV-visible spectroscopy was used to analyze the binding rate of TSG-EGCG covalent complex and the binding conditions were optimized. The effects of adding different amounts of TSG-EGCG covalent complex on the cooking loss, water-holding capacity and texture of emulsified sausages were studied using a color difference meter, a texture analyzer and a scanning electron microscope (SEM). The results showed that reaction at pH 9.5 and 30 ℃ with a mass ratio of TSG to EGCG of 1:0.1 gave the maximum binding rate. Compared with TSG, the microstructure of emulsified sausages added with TSG-EGCG complex was more compact, the three-dimensional gel network was more uniform and clear, and the cooking loss, water-holding capacity and texture properties were significantly improved. In conclusion, TSG-EGCG complex can improve the sensory quality of emulsified sausages, and the quality of emulsified sausages can be significantly improved by adding 2% of TSG-EGCG complex.

In order to solve the forming problems such as difficult deformation and easy cracking of high strength steel square tubes, the local induction heating technology has been introduced based on the traditional cold forming process. An electromagnetic-temperature multi-field coupling model for local induction heating is established by using ANSYS parametric design language based on the magnetic vector potential and physical environment method. A numerical simulation is conducted at different heating process parameters, and the optimized parameters are used for experimental research. The simulation results show that the induction heating efficiency can be significantly improved by using magnetizers to increase the magnetic field intensity. As the heating frequency increase, the heating speed of the outer fillet area and the temperature difference between the outer and inner fillet area increase. As the heating power increases, the high temperature area and the peak temperature increase, but the outer fillet area is more prone to be overheated. The experimental results show that a high strength steel square tube with an extremely small fillet radius, increased corner thickness, but with no crack defect can be obtained by using the optimized heating process parameters. The average error between the simulated and measured heating temperature is about 7.57%, indicating that the finite element model has a good prediction accuracy.

Background Helicobacter pylori (H.pylori) infection is strongly associated with peptic ulcer, gastric cancer, gastric lymphoma, and other diseases. A new dual therapy has proven effective in the eradication of H.pylori, but it has not been verified in some areas with a high prevalence of H.pylori infection in central China. Objective To explore the clinical efficacy of rabeprazole combined with amoxicillin or furazolidone dual therapy in the eradication of H.pylori infection. Methods 161 patients with a first diagnosis of H.pylori infection were recruited from Department of Gastroenterology, Henan Provincial People's Hospital during April 2020 to October 2021, and randomized into three groups with different 14-day therapies: group A (n=55) received a twice-daily quadruple therapy consisting of rabeprazole (20 mg) + bismuth potassium citrate (220 mg) + amoxicillin (1 000 mg) + furazolidone (100 mg) , group B (n=54) received a three-time daily dual therapy consisting of rabeprazole (20 mg) + high-dose amoxicillin (1 000 mg) , and group C (n=52) received a three-time daily dual therapy consisting of rabeprazole (20 mg) + high-dose furazolidone (100 mg) . The eradication rate, side effects and cost-effectiveness ratio were compared among the groups. Results Intention-to-treat analysis (ITT) revealed that, the eradication rates of H.pylori in groups A, B and C were 83.6% (46/55) , 81.5% (44/54) and 48.1% (25/52) , respectively. Per-protocol (PP) analysis found that, the eradication rates of H.pylori in groups A, B and C were 88.5% (46/52) , 83.0% (44/53) and 51.0% (25/49) , respectively. Both analyses demonstrated that groups A, B had higher eradication rates of H.pylori than group C (P

Background Helicobacter pylori (H. pylori) infection induced precancerous lesions of gastric mucosa mostly in adulthood. However, it is debatable whether these pathological changes could also occur in children. Objective To investigate the relationship between H. pylori infection and precancerous lesions of gastric mucosa in children hospitalized due to upper gastrointestinal symptoms in central plain area of China. Methods A total of 1 015 children under the age of 18 years old were enrolled. These children attended the People's Hospital of Zhengzhou University for upper gastrointestinal symptoms such as abdominal pain, bloating, nausea, vomiting, hiccups, and acid reflux from August 2018 to July 2021. All children underwent gastroscopy, from which gastric mucosal biopsy tissues were taken for rapid urease test and histopathological examination. The clinical and pathological data of the patients were collected retrospectively. The children were divided into infected and uninfected groups according to H. pylori infection status. The age, sex, endoscopic diagnosis, and H. pylori infection rate were compared between children in infected and uninfected groups. The incidence of precancerous lesions of gastric mucosa, inflammatory activity and the degree of inflammatory cell infiltration were compared between infected and uninfected groups, meanwhile these tests were also compared in children of different age groups. Results Among the 1 015 children, 854 (84.14%) were infected with H. pylori and 161 (15.86%) were not infected. H. pylori-infected children were significantly older than those of non-infected subjects (P

In order to enrich the variety of space structure materials,expand the application range of Zr alloy.Zr-Al binary alloys with Al content of 2%,3% and 4% were melted in a non-consumable arc furnace and annealed at 750 ℃ and 800 ℃ for 4 h,respectively.The microstructure and fracture morphology of the alloy were analyzed by means of optical microscope,X-ray diffractometer and scanning electron microscope,and hardness and tensile tests were carried out.The results show that the as-cast microstructure of Zr-4Al alloy changes from α-Zr and Zr2Al to α-Zr and Zr3Al phases with better plasticity after annealing at 750 ℃ for 4 h.Under the same heat treatment conditions,the hardness and tensile strength of alloy increase with the increase of Al content,but the elongation decreases.With the same Al content in the alloy,the hardness,tensile strength and elongation of alloy decrease with the increase of heat treatment temperature.A new Zr-Al alloy was prepared by adding Al to Zr and heat treatment,which provided a new idea for the development of new spatial structure materials.

In order to avoid excessive use of natural sand and gravel materials as aggregates of asphalt mixtures and to comply with the strategic policy of green development, solid waste iron tailings are used to replace sand and gravel materials to prepare a new type of iron tailings asphalt mixture. A mass spectrometer was used to analyze the chemical composition of the selected iron tailings. The penetration, penetration, softening point, ductility, viscosity and aging durability of asphalt mixture under different iron tailings content are studied. The research results show that the optimal preparation temperature of iron tailings asphalt mixture is selected as 180℃. Comprehensive analysis of economic benefits and effectiveness can determine the optimal content of iron tailings is 30%. Compared with the aged iron tailings asphalt material, the penetration and ductility of the two different asphalt mixtures before aging have a tendency to decrease under the same iron tailing content. However, under the effect of the same iron tailings content, the softening point of the two different asphalt mixtures before aging has a tendency to increase. Comprehensive analysis can be obtained: the asphalt mixture prepared with a temperature of 180°C and an iron tailing content of 30% can meet the road requirements of highways. The spectrum change law of all asphalt samples is basically the same. It shows that the structure of modified asphalt mixed with iron tailings is basically the same as that without iron tailings asphalt. However, with the increase of the iron tailings content, the FT-IR spectrum of the asphalt shows a decreasing trend under the same wave number. It shows that iron tailings can effectively improve the physical properties of asphalt.

Objective To explore expression changes of high affinity IgG receptor Fc-gamma Ⅰ type(FcγRⅠ) in brain cortex of patients with Alzheimer's disease(AD). Methods Normal human brain tissue samples and brain tissue samples with neuropathological diagnosis of AD, wild type mice and APP/PS1 mice were used. Immunofluorescence and Western blot were used to define cellular localization and expression of FcγRⅠ in cerebral cortex. Results FcγRⅠ was generally expressed in neurons of human and mouse cerebral cortex. Compared with normal human brain, FcγRⅠ expression in AD human brain cortex decreased significantly(P＜0.05). Compared with wild type mouse brain, FcγRⅠ expression in cerebral cortex of AD mouse models also decreased significantly(P＜0.05). Conclusions The expression of IgG high affinity receptor FcγRⅠ in AD human brain and cerebral cortex of AD mouse models decreases significantly that suggestes that FcγRⅠ is potentially correlated with AD neuropathological pathogenesis.

In this study, antibacterial PVA-SS-LJ-AgNPs composite films were made by using polyvinyl alcohol (PVA) and soluble starch (SS) as ingredients, glycerol as plasticizer, and lemon juice (LJ) as reducing agent to in situ reduced AgNPs from AgNO3. After single factor and orthogonal experiments, the optimum films preparation process was PVA 3 g, SS 0.5 g, glycerol 3 g, LJ 7 mL, AgNO3 130 mmol/L. Under the optimal process, the tensile strength, elongation at break, water vapor permeability coefficient, moisture absorption rate, and light transmittance of the membrane were 12.16 MPa, 1111.59%, 0.09 g/0.01 h·m2, 12.56%, 48.05%, respectively. Through the analysis of physical properties and structure of the films, lemon juice could successfully restore AgNPs in situ to films. Compared with the PVA-SS films, the tensile strength and elongation at break of the composite films were improved up to 11.51 MPa and 1470.20%, respectively. Compared with PVA-SS-LJ films, the water vapor penetration and moisture absorption were effectively balanced, AgNPs evenly dispersed in the composite films, the compound films had good inhibition effect for E. coli, Salmonella, Bacillus subtilis, S. aureus, P. aeruginosa. In summary, PVA-SS-LJ-AgNPs composite films met the current new requirements of food packaging materials, and had its potential application prospects.

A method was developed for the residual quantity determination of 12 mycotoxins in seasoning flour products by QuEChERS-SPE-ultra performance liquid chromatography-tandem mass spectrometry. The samples were extracted with formic acid acetonitrile aqueous solution and salted out by adding sodium chloride and anhydrous magnesium sulfate. The supernatant was taken and purified by Prime HLB column extraction. The purified liquid was further cleaned up by adding anhydrous magnesium sulfate, PSA, C18 and Al-N. The target compound, which was separated with Waters CORTECS C18+ column, was eluted by gradient elution. The electrospray ion source (ESI) positive ion mode and multiple reaction monitoring mode (MRM) were used for mass spectrometry. Take negative samples as ground substance whitespace along with matching standard curve. The quantification was achieved by external standard method. The results showed that within the scope of 0.3~1000 ng/mL, the linear relationships of 12 mycotoxins were very good, the determination coefficient (R2) of which were higher than 0.99. The limits of detection were 0.10~3.0 μg/kg, and the limits of quantity were 0.30~10.0 μg/kg. Under the adding levels of high and medium as well as low, the average adding standard recoveries of 12 mycotoxins were 84.2%~97.2% and the relative standard deviations (RSDs) were 3.25%~8.77% (n=6). This method with high recovery rate and high sensitivity was rapid and accurate, which would be used to simultaneously determinate the 12 mycotoxins in seasoning flour products.

The objective of this paper was to develop seabuckthorn powder chewable tablets primarily with seabuckthorn fruit powder and jujube powder mixed with edulcorants and tablet additives. The optimal formulation of seabuckthorn powder chewable tablets was determined by D-optimal mixture design, means of one-factor-at-a-time experiments, and Box-Behnken design combined with multi-index evaluation method, and its sensory index, nutritional components and total antioxidant capacity were analyzed. The results showed that the best flavor formula of mixed seabuckthorn fruit powder was: Seabuckthorn fruit powder 47.79%(percentage of mass, the same below), jujube powder 35.72% and xylosic alcohol 16.49%, sensory score was 18.5±0.2 points. The optimum formula of tablet ingredients was determined as magnesium stearate 1.3%, microcrystalline cellulose 23.0% and lactose 26.6%. The tablet weight variation, hardness and brittleness were 0.76%, 89.4 N and 1.20% respectively, and the average comprehensive score was 30.4 points. The prepared seabuckthorn powder chewable tablets meet the sensory evaluation standards of products, are rich in nutrition, high in bioactive components, and have strong total antioxidant capacity.

Recently,we are facing the increasingly large and complex intelligent applications in cloud computing.Establishing an effective quality model of cloud service is an important methodology to evaluate cloud service quality.However,due to the diversity and dynamic characteristics of intelligent cloud resources,it is very difficult to evaluate the service efficiency of intelligent cloud.At present,there is a lack of standard and unified cloud service quality evaluation and cloud service model in the field of intelligent cloud computing.In this paper,the abstract service quality of intelligent cloud is embodied as cloud service efficiency,and cloud service efficiency is defined as the service availability,reliability and performance reflecting service efficiency.That is to quantitatively evaluate the overall service capability of intelligent cloud through the output of cloud service efficiency.Moreover,this paper proposes an efficiency model of intelligent cloud based on BP neural network.The complex nonlinear relationship between input characteristics and output service efficiency of intelligent cloud is simulated by BP neural network.Once the input characteristics are determined,the output service efficiency can be computed.The efficiency model is responsible for predicting the service level of the current system in real time according to the input characteristics of the system accurately.The experimental results show that the BP neural network model,as a modeling tool of service efficiency model,has good computing efficiency and accuracy.

BackgroundPhysical activity during pregnancy has recently been considered as an essential part of reproductive health, and pregnant women are encouraged to adopt an active lifestyle instead of traditionally restricting their activities. Studies from abroad have shown that pregnancy physical activity gradually decreases with the progress of pregnancy. Domestic studies on the patterns and changes of pregnancy physical activity are still insufficient.ObjectiveTo explore the pattern of physical activity in the first, second and third trimesters of pregnancy, and its change trajectory, providing a reference for the formulation of targeted interventions.MethodsConvenience sampling was used to select low-risk pregnant women from Obstetric Clinic, Jiangmen Wuyi Hospital of Traditional Chinese Medicine from May 2017 to May 2018. All had a health file created at 6-13+6 weeks' gestation at the first antenatal examination. A self-developed questionnaire was used to collect general demographic data. The Chinese version of the Pregnancy Physical Activity Questionnaire was used to investigate physical activity in the first, second and third trimesters of pregnancy. Patterns and changes of physical activity were analyzed by the stage of pregnancy.ResultsAmong the 312 participants, except for 48 excluded cases and 15 dropouts, the other 249 who completed the survey were finally included. The average weekly metabolic equivalent of task (MET) values for the respondents in the first, second and third trimesters of pregnancy were 201.7, 188.6, and 177.2 MET-hours, respectively. Sedentary activity, light-intensive activity, moderate-intensive activity, and vigorous-intensive activity accounted for 17%, 60%, 21.2%-24.4%, and less than 1% of the energy expenditure attributable to total activity, respectively. In terms of activity type, household/caregiving, occupational, transportation and sports/exercise accounted for 48%, 40%, 9%, and less than 3% of the energy expenditure attributable to total activity, respectively. The differences in MET values of sedentary activity, light-intensive activity, moderate-intensive activity, and vigorous-intensive activity, household activity, sports/exercise, and total activity across three stages of pregnancy were statistically significant (P

Continuous glucose monitoring is important in the management of diabetes. According to statistics, diabetes is the third chronic non-infectious disease that seriously endangers people's health, followed by tumor as well as cardiovascular and cerebrovascular diseases. In 2019, globally, there were a total of 460 million diabetics aged 20–79 years, which accounted for 9.1% of the total population in this cohort. Each figure is projected to increase to 592 million and by 10.1% respectively by 2035. Currently, the methods of blood glucose monitoring can be divided into invasive, minimally invasive, and noninvasive. The main methods for blood glucose monitoring include irregular sampling of fingertip blood or consecutive measurement of interstitial fluid glucose based on implantable sensors. However, these methods have some limitations, which include pain sensation, high cost, short service life, and susceptibility. Patients need to measure their blood glucose frequently. Invasive and minimally invasive monitoring will cause physical and psychological pain. Therefore, noninvasive monitoring is one of the most promising techniques for continuous monitoring of blood glucose, and it has a broad market prospect. In this study, the electrocardiogram (ECG signals) were used to achieve the noninvasive monitoring of blood glucose levels. First, 756160 ECG periodic signals of 12 volunteers for 60 d were obtained from the experiment. Second, the ECG signals were preprocessed using an infinite impulse response filter. Furthermore, a method combining convolutional neural networks and long short-term memory networks (CNN-LSTM) was proposed for blood glucose monitoring. In Addition, two modeling methods (individual modeling and group modeling) were investigated in this study. The results show that the precision of blood glucose monitoring under the condition of individual and group modeling is 80% and 88%, respectively. The F1-score of the group modeling can reach 0.95, 0.88, 0.91, 0.85, 0.92, 0.88, 0.86, 0.86, 0.87, and 0.86. Therefore, this study indicates that the proposed method based on ECG signals can provide powerful theoretical support and technical guidance for real-time and accurate blood glucose monitoring.

The China Spallation Neutron Source (CSNS) is the first medium and high energy, high current, high power proton accelerator in China. From the linear accelerator to the rapid cycle synchrotron, it faces a lot of challenges from the physical design of the accelerator to a large number of key technologies. On the basis of overcoming these challenges and technical difficulties one by one, we officially started construction of project in September 2011, passed the test in March 2018, and successfully completed the project construction on schedule. After the facility was officially opened to users in September 2018, the beam commissioning was done according to the plan during the user operation, and the beam power increased continuously. In February 2020, the designed beam power 100 kW was reached, and it is one and a half years ahead of schedule. The beam commissioning time for the beam reaching the design target was much less than that of similar facilities. Through further efforts, the beam power reached 125 kW in February 2022. Beam commissioning plays an important role in the construction of accelerator. The meticulous research and preparation work in the early stage and the new method developed in beam commissioning, provide a guarantee for the successful beam commissioning. After the formal user operation, the operation is stable and reliable, the beam supply time and accelerator beam supply efficiency are continuously improved, and the user running time and efficiency have reached the best level among the similar facilities in the world. The second phase of CSNS project will be started soon. In the second phase, the beam power will be upgrade to 500 kW. At present, the detailed design and the R&D of the key technologies for the accelerator upgrade have been making. This paper comprehensively introduced the design, key technical challenges and devices development of the CSNS accelerator, the beam commissioning process was also introduced, and the key problems and the corresponding solutions in the beam commissioning were described.

The performance of fi ber-based FSO with multiple apertures receiver system was studied for pulse position modulation (PPM) .Expressions of PPM modulated signal-to-noise ratio (SNR) and bit-error rate (BER) for fi ber-based FSO multiple apertures receiver system were presented based on the probability density function of Gamma-Gamma intencity distribution and non–central chisquare fi ber coupling effi ciency distribution under atmospheric infl uence.Selection combining (SC), equal gain combining (EGC) and maximum ratio combining (MRC) were considered to be three signal combining methods for multiple apertures receiver system.The BER performance of 4PPM modulted SC, EGC and MRC fi ber-based multiple apertures receiver system and single aperture receiver system with the same total aperture area were comparative analyzed by Monte Carlo simulation.The BER performance of fi ber-based multiple apertures receiver systems in 4PPM and 8PPM modulation modes were directly compared for diff erent combining methods.

In order to improve the oxidation resistance of 304 stainless steel, SiO2 thin film was prepared on the surface of stainless steel by sol-gel method with tetraethyl orthosilicate (TEOS) as raw material. The effect of film layers on the high temperature oxidation resistance of stainless steel at 900 ℃ was studied by means of oxidation kinetics, XRD, SEM and EDS. The results show that the adhesion of SiO2 film to stainless steel matrix is good, which promotes the selective oxidation on the stainless steel surface and the formation of protective Cr2O3 and NiCr2O4 oxide layers. The high temperature oxidation resistance of stainless steel is improved remarkably. The oxidation resistance of the sample coated with three layers of SiO2 film proforms the best, and the oxidation weight gain and oxidation spalling of the sample are only 58.1% and 41.4% of the uncoated sample after 100 hours of cyclic oxidation at 900 ℃. The high temperature oxidation resistance of stainless steel is effectively improved through SiO2 film coating, which is another attempt of surface treatment method applied to high temperature environment, and provides reference for other thin films prepared by sol-gel method.

In order to study the effect of anisotropy on the safe service of B+F dual-phase X80 pipeline steel, the slow strain tensile and polarization behaviors of hot rolled ferrite + bainite dual-phase X80 pipeline steel at three angles(0°, 45° and 90°) with rolling direction were analyzed by metallography, scanning electron microscopy, slow strain tensile test and electrochemical polarization method in simulated seawater. The result shows that the dual-phase X80 pipeline steel is composed of polygonal ferrite and lath bainite, and the content ratio of ferrite and bainite is about 1∶1. The slow tension yield strength of X80 pipeline steel with different angles from rolling direction decreases significantly with the increase of sampling angle in simulated seawater environment, which indicates that seawater has obvious stress corrosion to X80 pipeline steel; the slow strain tensile stress-strain curve of B+F dual-phase X80 pipeline steel parallel to rolling direction(0°) shows dome shape, the yield strength and tensile strength are the highest, the yield strength ratio is 0.81, and the uniform elongation is 13.4%, which can meet the application requirement; the self-corrosion potential of B+F dual-phase X80 pipeline steel perpendicular to the rolling direction(90°) is the most negative and the self-corrosion current is the largest, which indicates the seawater corrosion resistance is the worst; the corrosion resistance of dual-phase pipeline steel in the direction of 45° from the rolling direction in simulated seawater is the best due to the most positive self-corrosion potential. The research on the slow strain tensile anisotropy of B+F dual-phase X80 pipeline steel in simulated seawater environment can improve its safe service, and has some reference value for the actual production of large deformation pipeline steel.

In order to improve the high temperature oxidation resistance of Fe-Cr alloy, cast Fe-Cr alloys with different Cr contents are treated by electrospark deposition to get microcrystalline structure. The oxidation behavior of as-cast and microcrystalline Fe-Cr alloys at 900 ℃ in air is studied. Oxidation kinetics curves, phase analysis,surface and cross section morphology results show that the diffusion rate of chromium is enhanced by microcrystallized treatment when Cr content is low. Yet the content of Cr is not enough to form continuous oxide film so that the oxidation resistance of Fe-5Cr alloy is decreased. The critical Cr content to form protective oxide scale is reduced by microcrystallized treatment when Cr content increases. The oxidation resistance of microcrystalline Fe-9Cr and Fe-13Cr alloys is obviously improved. The high temperature oxidation resistance of microcrystalline Fe-13Cr alloy is the best, which is due to the formation of continuous dense protective oxide scale on the surface after microcrystallized treatment. Therefore, Microcrystallization treatment is an effective way to improve high temperature oxidation resistance of materials which can be applied in the field of high temperature oxidation.

Background Obstructive sleep apnea-hypopnea syndrome (OSAHS) and rapid eye movement sleep behavior disorder (RBD) are two common sleep disorders in Parkinson's disease (PD). This paper aims to explore the changes of clinical features and sleep parameters, as well as the mutual effect in PD patients with concurrent OSAHS and RBD. Methods Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) Chinese Version, Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Non-Motor Symptoms Questionnaire (NMSQuest), Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), 39-Item Parkinson's Disease Questionnaire (PDQ-39) and Hoehn-Yahr stage were used to assess the motor symptoms, non-motor symptoms (cognitive function, sleep quality, autonomic function), and the severity of disease of 190 PD patients. Polysomnography (PSG) monitoring was done to record sleep parameters. Results Among those patients, 73 patients were accompanied by OSAHS, among whom 22 patients also suffered from RBD (PD + OSAHS + RBD), and 51 patients did not present RBD (PD + OSAHS - RBD). The scores of UPDRSⅠ (P = 0.015), UPDRSⅡ (P = 0.023), ESS (P = 0.002), PSQI (P = 0.048), NMSQuest (P = 0.001) and SCOPA - AUT (P = 0.026) in PD + OSAHS + RBD group were significantly higher than those in PD + OSAHS - RBD group, while MoCA score was significantly lower (P = 0.013). PSG monitoring showed mean artery oxygen saturation (SaO2, P = 0.029), mini SaO2 (P = 0.001), mini SaO2 in REM (P = 0.000), tonic EMG activity (P = 0.000) and phasic EMG activity (P = 0.000) in REM in PD + OSAHS + RBD group were significantly higher than those in PD + OSAHS - RBD group. Correlation analysis showed that apnea hypopnea index (AHI) and oxygen desaturation index (ODI) were positively correlated with the scores of NMSQuest (rs = 0.252, P = 0.032; rs = 0.229, P = 0.010), SCOPA-AUT (rs = 0.322, P = 0.005; rs = 0.247, P = 0.037) and PDQ-39 (rs = 0.340, P = 0.004; rs = 0.269, P = 0.023). Conclusions PD with concurrent OSAHS and RBD can aggravate the non-motor symptoms such as cognitive dysfunction, daytime sleepiness and autonomic dysfunction. Although RBD patients present higher SaO2 at night, it cannot release the symptom of anoxia in PD patients with OSAHS. DOI: 10.3969/j.issn.1672-6731.2017.01.007

ZnO and Fe-doped ZnO thin films are prepared on glass substrate by sol-gel method, and the surface morphology, structure and optical property are analyzed by scanning electron microscope (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD) and UV-Vis-NIR spectrophotometer. The results show that both films have a smooth surface and a hexagonal wurtzite structure with orienting along the (101) plane. Compared with the ZnO film, the surface of Fe-doped ZnO film becomes smoother, and its grain size decreases from 58.512 nm of the ZnO film to 36.460 nm. Moreover, after Fe doping, the orientation degree of (101) plane is weakened, and the optical band gap energy increases from 3.1 eV of the ZnO film to 3.4 eV.

Al2O3 thin films are deposited on the surface of 304 stainless steel by electrodeposition-pyrolysis, and the effects of electrolyte concentration and electro-deposition voltage on the oxidation behavior of Al2O3 thin film at 900 ℃ are investigated. Macroscopic surface morphologies, XRD analysis and oxidation kinetics curves show that the electrodeposition-Al2O3 thin films reduce the partial pressure of oxygen at the initial oxidation stage on the substrate surface, promoting the selective oxidation, thus the oxidation resistance of 304 stainless steel is significantly improved. The high temperature oxidation resistance of Al2O3 film prepared under voltage of 25 V and aluminum nitrate alcohol solution of 0.10 mol/L is the best.

The article presents a study which investigates the mechanism of the interaction between copper (Cu) and several multifold mutants of myoglobin, which include D44K, D60K, and K56D, by spectroscopic techniques. Topics discussed include polymerase chain reaction (PRC) site-directed mutagenesis, statistic fluorescence quenching, and conformation and function of myoglobin.

Hypertension is a kind of chronic cardiovascular system disease caused by a series of factors and carriers dysfunction, which belongs to the category of Tibetan medicine &quot;Chalong disease&quot;, and has a high rate of disability and mortality. Zuomua Decoction is a classical Tibetan medicine for Chalong disease, but its mechanism is not clear. Therefore, in this paper we explored the multi-components, multi-targets and multi-channels mechanism of Zuomua Decoction in the treatment of hypertension based on network pharmacology and molecular docking technology. First of all, the chemical components of Zuomua Decoction were obtained in the retrieval of traditional Chinese medicine systems pharmacology database(TCMSP), China National Knowledge Infrastructure(CNKI) and Wanfang database. The potential targets of Zuomua Decoction were predicted by BATMAN-TCM database, and the targets of hypertension were obtained by using DisGeNET database. The intersection of these two targets set was taken to obtain the potential targets of Zuomua Decoction in the treatment of hypertension, and then the chemical compositions-targets network was constructed. Secondly, the intersection targets were imported into STRING database to obtain the interaction relationship of intersection targets, and the protein interaction network of Zuomua Decoction in the treatment of hypertension was constructed in Cytoscape. Topological, GO, and KEGG enrichment analysis were used to construct the key targets-signal pathways-biological processes network diagram and explore the mechanism of Zuomua Decoction in the treatment of hypertension. Finally, the key targets were selected to construct the pharmacodynamic identification models to verify the effect mode of Zomua Decoction in treating hypertension. The results showed that there were 61 chemical components and 90 potential targets in the compounds-targets network. We obtained 21 key targets, 154 signal pathways, and 382 biological processes in topological, GO, and KEGG enrichment analysis of the protein interaction network, and in the comprehensive analysis, it was found that Zuomua Decoction could reduce blood pressure by regulating renin angiotension aldosterone system, balancing the concentration of intracellular calcium and sodium ions and regulating vasoconstriction and relaxation. ACE, AGTR1, and ADRB2 were used as the carriers for molecular docking study on the components of Zuoma Decoction, and the results showed that the chemical components of Zuomua Decoction had a good binding activity with key targets. The purpose of this study is to provide ideas for the in-depth study of Zuoma Decoction in the treatment of hypertension, and provide scientific basis for its clinical rational application.

Syringa pinnatifolia is an endemic species of Syringa in Oleaceae family in China, mainly distributed in Helan Mountain, which is located between Inner Mongolia and Ningxia. Its peeled roots, stems and thick twigs have been used as Mongolian folk medicine, called &quot;Shan-chen-xiang&quot; in Chinese, for the treatment of coronary heart diseases, angina pectoris and other cardiopulmonary diseases. Modern researches showed that S. pinnatifolia mainly contains lignans, sesquiterpenoids, and volatile oils, and displays anti-myocardial ischemia, sedation, analgesia, antibacterial and other effects. In the past five years, many groups have made new progress on the study of chemical constituents and pharmacological activities of S. pinnatifolia. On the basis of the previous review by our group, this paper summarizes the advances which is beneficial to the development, research and clinical application of S. pinnatifolia, particularly Shan-chen-xiang.

Objective: To investigate the effect of PPARgamma1 gene overexpression on caveolin-1 mRNA and protein expressions in a murine macrophage cell line Raw264.7., Methods: Replication-deficient recombinant adenovirus expression vector of PPARgamma1 was constructed using the AdEasy system. Raw264.7 cells were randomly treated as follows: P group (PPARgamma1 gene overexpression), T group (Troglitazone 40 micromol/L in DMSO), PT group (PPARgamma1 gene overexpression and Troglitazone) and control group. Changes of PPARgamma1 and caveolin-1 at mRNA and protein levels were investigated., Results: Caveolin-1 expression can be detected by RT-PCR in Raw264.7, by immunocytochemistry method in cell and nuclear membrane but not by immunoblotting at protein level. Caveolin-1 expression at mRNA and protein levels in Raw264.7 were significantly higher in P, T and PT groups compared to control group and the expression was also significantly higher in PT group than that in P group and T group (P < 0.05). PPARgamma expression was significantly increased in PT group and P group where remained unchanged in T group compared to control group., Conclusion: PPARgamma1 overexpression can upregulate caveolin-1 expression in macrophages. Troglitazone upregulated caveolin-1 expression in the absence of increased PPARgamma1 expressions at mRNA and protein levels.