1. [Antianaphylactic components of Asarum forbsii Maxin].
- Author
-
Bian RL, Xie QM, Kobayashi M, Asai M, Ishiguro T, and Kishi T
- Subjects
- Animals, Benzoates chemistry, Butyrates chemistry, Cinnamates chemistry, Female, Linoleic Acid, Linoleic Acids chemistry, Linoleic Acids isolation & purification, Linoleic Acids pharmacology, Male, Rats, Valerates chemistry, Benzoates isolation & purification, Butyrates isolation & purification, Cinnamates isolation & purification, Drugs, Chinese Herbal chemistry, Passive Cutaneous Anaphylaxis drug effects, Valerates isolation & purification
- Abstract
From the ethyl acetate extract of Asarum forbesii Maxin, four new constituents, asarumin A(I), B(II), C(III) and D(IV), were isolated along with elemicin (V), trans-asarone(VI) and linoleic acid(VII). The structures of the new compounds were elucidated as methyl 3 S-benzoyloxy-2 S-hydroxy-2-isopropylbutyrate for I, methyl 2 R-benzoyloxyisopentanoate for II, methyl 2 R-trans-cinnamoyloxyisopentanoate for III and methyl 2 R-piperonyloyloxyisopentanoate for IV. Compounds I, II, III and VII showed weak inhibition of PCA in rats, but the other compounds were inactive.
- Published
- 1990