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Objective: To analyze the clinical characteristics, treatment, and survival of adult patients with renal leiomyosarcoma treated at our institution during the past 13 years., Methods: A retrospective review was performed to collect the demographic distribution, clinical manifestation, treatment, and outcome data about 13 adult patients of renal leiomyosarcoma treated at our institution from January 1996 to January 2008. The clinical parameters were analyzed to determine the effects on survival by logistic regression., Results: Mean age at diagnosis was 45.7 years (range 20 to 71), and 61.5% (8/13) were female. Mean tumor diameter was (11.1 +/- 10.2) cm (range 3 to 34 cm), 53.9% (7/13) had direct invasion of renal capsule, and 23.1% (3/13) had lymphovascular invasion. The follow-up information of 11 cases was available, and duration of follow-up was an average of 39.2 (range 9-81) months. The overall survival (OS) rate at 1, 3, and 5 years was 81.8%, 54.5%, and 16.2% respectively. 8 (72.7%) patients developed metastasis, and 9 (81.8%) patients eventually died. The survival of the patients did not show correlations with age, pathologic grade, extrarenal component, lymphovascular invasion, complete resection or not and chemotherapy or not., Conclusion: Primary renal leiomyosarcoma has a poor survival prognosis regardless of the underlying histological and clinical features.

Objective: To compare the operative outcomes and complications between an anterograde versus retrograde approach to open radical retropubic prostatectomy (RRP);, Methods: Retrospectively analyze the clinical data and follow-up results of 76 prostate cancer patients who received radical retropubic prostatectomy from April 2006 to May 2011. According to the resection approach of prostate, the patients were divided into two groups, antegrade RRP group (45 cases) and retrograde RRP group (31 cases). The operative outcomes and complications between two groups were analyzed., Results: There was no peri-operative death and cancer specific death during the follow-up. Eleven cases were found positive surgical margin, 5 (11.1%) in antegrade group, 6 (19.3%) in retrograde group. The estimated blood loss of these 76 operations were 230-1200 mL [mean (367.2 +/- 132.4) mL], (324.0 +/- 70.3) mL in antegrade group and (429.8 +/- 172.3) mL in retrograde group, respectively. The volume of blood loss between the two groups was significantly different. The durations of follow-up for the patients were 2-63 months [(24.22 +/- 13.21) months), 4 cases showed biochemical failure with criterion as prostate specific antigen > 0.2 microg/L, 2 patients had stress incontinence of antegrade RRP group and 1 patient had permanent incontinence of retrograde RRP group, there were no significant difference between the two groups., Conclusions: Antegrade radical prostatectomy provides a low incidence of complications, reduced blood loss for localized prostatic cancer.