11 results on '"Li, Hong-ru"'
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2. The method of grey Markov remaining service life prediction specific to generalized mathematical morphological particle.
- Author
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LI Hong-ru, WANG Yu-kui, WANG Bing, XU Bao-hua, and LI Xing-lin
- Abstract
In the domain of rolling bearing condition monitor and fault prognosis, to solve the key problem of rolling bearing degenerate feature extraction, a new approach based on generalized mathematical morphological particle is proposed in the paper, the new approach, which is founded on the mathematical morphological particle analysis, introduces corrosion and dilation operators in morphological calculation and takes the calculated generalized mathematical morphological particle as feature indicator, therefore, the performance degenerate degree could be reflected in quantity. The effectiveness of this approach is test and verified with simulation and actual signal. On this basis, in order to describe the whole tendency and random fluctuating feature for rolling bearings, grey Markov model is applied in the remaining service life prediction for rolling bearing, A method of remaining service life prediction based on generalized mathematical morphological particle and grey Markov model is proposed thereby. Rolling bearing fatigued life testing was proceeded with Hangzhou Bearing Test & Research Center, the approach is proved effective with the collecting bearing inner race whole life data in fatigued life testing. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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3. [Effect on follicular development and pregnancy outcome treated with acupuncture and moxibustion therapy of Tiaochongren Gushenyuan in patients with luteal phase defect].
- Author
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Yang LJ, Wu J, Yang L, Zhou T, Li HR, and Miao RQ
- Subjects
- Acupuncture Points, Female, Humans, Luteal Phase, Pregnancy, Pregnancy Outcome, Acupuncture Therapy, Infertility, Female therapy, Moxibustion
- Abstract
Objective: To observe the effect of acupuncture and moxibustion therapy of Tiaochongren Gushenyuan on ovulation and embryo implantation in luteal phase defect patients with spleen-kidney yang deficiency., Methods: A total of 80 patients were randomly divided into an observation group and a control group, 40 cases in each one.In the observation group,acupuncture was applied at Shenting (GV 24), Shenque (CV 8), Guanyuan (CV 4), Qixue (KI 13), Lieque (LU 7), Gongsun (SP 4), Taixi (KI 3), Zusanli (ST 36) and Taichong (LR 3). And moxibustion was given at Taixi (KI 3) using moxibustion box during follicular phase, the stimulation of Taichong (LR 3) was strengthened during ovulatory phase, moxibustion was adopted at Shenque (CV 8) to Guanyuan (CV 4), Zusanli (ST 36) and Taixi (KI 3) during luteal phase. In the control group, acupuncture was applied at Guanyuan (CV 4), Dahe (KI 12), Sanyinjiao (SP 6), Ciliao (BL 32), Zhibian (BL 54) and Shenque (CV 8). Moxibustion was given at Sanyinjiao (SP 6) using moxibustion box during follicular phase, and moxibustion was adopted at Shenque (CV 8) to Guanyuan (CV 4) during luteal phase. The treatment were given every Monday, Wednesday and Friday, and the treatment were stoped during menstrual period in the two groups. Totally 3 menstrual cycle treatment were required, and 3 menstrual cycles were followed up. The pregnancy rate was observed after treatment, the ovulation rate, maximum folliclular diameter and difference of maximum folliclular diameters in ovulatory phase, serum progesterone (P) and basal body temperature (BBT) were compared before and after treatment in the two groups., Results: In the observation group, 6 cases of successful pregnancy during treatment,10 cases in follow-up, the clinical pregnancy rate was 40.0% (16/40). In the control group, 1 case of successful pregnancy during treatment, 5 cases in follow-up, the clinical pregnancy rate was 15.0% (6/40). The clinical pregnancy rate in the observation group was higher than the control group ( P <0.05). The ovulation rate after treatment in the observation group was 90.0% (36/40), and the control group was 70.0% (28/40), compared before treatment, the ovulation rates were increased after treatment in the two groups ( P <0.05). The observation group was higher than the control group, but there was no significant difference between the two groups ( P >0.05). Compared before treatment, the maximum folliclular diameter and difference of maximum folliclular diameters in ovulatory phase, serum P after treatment were improved in the two groups ( P <0.05), and the improvements of the observation group were significant compared with the control group ( P <0.05). The BBT after treatment were superior to before treatment in the two groups ( P <0.05). After treatment, the normal BBT in the observation group was 33 cases, while the control group was 22 cases ( P <0.05)., Conclusion: Acupuncture and moxibustion therapy of Tiaochongren Gushenyuan can promote folliclar development, improve dominant follicle morphology, increase the level of serum P. The therapeutic effect is superior to routine acupuncture in increasing ovulation rate and improving pregnancy outcome.
- Published
- 2019
- Full Text
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4. [Discussion on opposing needling combined with dragon-tiger fighting needling for chronic pelvic inflammation].
- Author
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Yang LJ, Yang M, Miao RQ, Yu L, and Li HR
- Subjects
- Acupuncture Points, Female, Humans, Inflammation, Medicine, Chinese Traditional, Acupuncture Therapy, Moxibustion, Pelvic Inflammatory Disease therapy
- Abstract
Opposing needling is an acupoint selection method of acupuncture recorded in Huangdi Neijing ( Yellow Emperor ' s Internal Classic ). And the first record of dragon-tiger fighting needling is found in the Zhenjiu Daquan ( Great Compendium on Acupuncture and Moxibustion ), it is a compound reinforcing and reducing manipulation of tonification-purgation method. Both of them are widely used in the treatment of pain syndrome, which are mainly for nerve system and musculoskeletal diseases and seldom for gynecological diseases. By analyzing the pathogenic characteristics of chronic pelvic inflammation, the clinical application of opposing needling combined with dragon-tiger fighting needling for chronic pelvic inflammation is expounded based on the theory of treating different diseases with the same treatment in TCM.
- Published
- 2019
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- View/download PDF
5. [Diagnostic investigation of the detection of granulocyte-macrophage colony stimulating factor antibody in serum for pulmonary alveolar proteinosis].
- Author
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Li YQ, Chen YS, Li HR, Shang Y, and Gao ZC
- Subjects
- Adult, Biomarkers blood, Biopsy, Bronchoalveolar Lavage Fluid chemistry, Bronchoalveolar Lavage Fluid immunology, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Lung pathology, Lung Diseases, Obstructive diagnosis, Lung Diseases, Obstructive immunology, Lung Diseases, Obstructive pathology, Male, Middle Aged, Pulmonary Alveolar Proteinosis immunology, Pulmonary Alveolar Proteinosis pathology, Sensitivity and Specificity, Severity of Illness Index, Autoantibodies blood, Granulocyte-Macrophage Colony-Stimulating Factor immunology, Pulmonary Alveolar Proteinosis diagnosis
- Abstract
Objective: To evaluate the diagnostic value of granulocyte-macrophage colony stimulating factor (GM-CSF) antibody in serum for pulmonary alveolar proteinosis (PAP)., Methods: Twelve PAP patients visiting Peking University People's Hospital or Fujian Provincial Hospital from January 1, 2002 to December 31, 2012, 25 patients with other pulmonary diseases (disease control), and 25 healthy volunteers (healthy control) were recruited in the study. The titer level of GM-CSF antibody in serum was determined with enzyme-linked immunosorbent assay (ELISA), and the clinical characteristics were collected in the PAP patients., Results: The geometric mean titers of GM-CSF antibody in the PAP patients, the disease controls and the healthy controls were 1: 25 349, 1: 311 and 1: 256, respectively. The differences between the disease controls and the healthy controls were of no statistic significance (t = -1.14, P = 0.261) . With 3 times standard error (3s) above the mean value as the higher limit of X value(X = lgT, T standing for the reciprocal of the titer), the upper limit for T was 1698. With the T value ≥ 1698 as the diagnostic threshold for PAP, both the sensitivity and the specificity were 100%. The diagnostic value of GM-CSF antibody was similar to that of surgical lung biopsy and higher than that of transbronchial lung biopsy., Conclusion: The detection of serum GM-CSF is non-invasive, convenient and efficient for the diagnosis of PAP with high sensitivity and specificity.
- Published
- 2013
6. [Association between polymorphisms of insulin-like growth factor receptor gene and susceptibility to non-small-cell lung cancer in Fujian Chinese].
- Author
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Li HR, Chen YS, Shao H, Han LL, and Zhang XE
- Subjects
- Adult, Aged, Aged, 80 and over, Asian People, Base Sequence, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Carcinoma, Non-Small-Cell Lung genetics, Lung Neoplasms genetics, Receptors, Somatomedin genetics
- Abstract
Objective: To assess the association between polymorphisms of insulin-like growth factor receptor (IGF-1R and IGF-2R) and genetic susceptibility and non-small-cell lung cancer (NSCLC)., Methods: A case-control study of 260 patients with NSCLC and 258 cancer-free subjects from Fujian was carried out. Genotypes of polymorphisms of IGF-1R +1013 and IGF-2R +1619 were determined by DNA sequencing and polymerase chain reaction-restrictive fragment length polymorphism., Results: (1) Significant differences in allele frequency and genotypes distribution of IGF-1R +1013 (G/A) were found between the two groups (P<0.05). On multivariate analysis after controlling age and gender, compared with GG genotype of the IGF-1R +1013 (G/A), the risk of lung cancer for individuals with GA genotype was increased by 0.80 times (95%CI: 1.24-2.59, P = 0.002), those with AA genotype was increased by 2.56 times (95%CI: 1.78-7.26, P = 0.000), and those with the polymorphic A variant (GA or AA) was increased by 0.98 times (95%CI: 1.39-2.83, P = 0.000). No significant differences in genotypic or allelic frequencies of IGF-2R +1619 (G/A) were found between the two groups (P> 0.05). (2) After stratification of the clinical status, the IGF-1R +1013 A allele increased the risk of lung squamous cell carcinoma (OR = 3.20, 95%CI: 1.75-5.84, P = 0.000), lung adenocarcinoma (OR = 1.55, 95%CI: 1.00-2.41, P = 0.049) and other types of lung cancer (OR = 1.96, 95% CI: 1.10-3.49, P = 0.023), but no association was found between the two SNPs and other clinical features. (3) IGF-1R +1013 (G/A) and IGF-2R +1619(G/A) polymorphisms showed a synergic effect (P = 0.003)., Conclusion: The common IGF-1R gene polymorphism G1013A may influence the risk of lung cancer. The polymorphisms of IGF-1R +1013 (G/A) and IGF-2R +1619 (G/A) have synergistic influence on the risk of lung cancer.
- Published
- 2012
- Full Text
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7. [A case-control study on the risk factors for lower respiratory tract infection by Stenotrophomonas maltophilia in a medical intensive care unit].
- Author
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Xu NL, Shi SJ, Lai ZS, Li HR, Lian SQ, and Chen YS
- Subjects
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Cross Infection mortality, Female, Gram-Negative Bacterial Infections microbiology, Humans, Logistic Models, Male, Middle Aged, Respiratory Tract Infections etiology, Risk Factors, Gram-Negative Bacterial Infections etiology, Intensive Care Units, Respiratory Tract Infections microbiology, Stenotrophomonas maltophilia
- Abstract
Objective: To explore the risk factors for lower respiratory tract infection by Stenotrophomonas maltophilia in the medical intensive care unit (MICU) in Fujian Provincial Hospital., Methods: A 1:4 matched case-control study was carried out in the MICU in Fujian Provincial Hospital. Thirty-five patients with hospital-acquired lower respiratory tract infection by Stenotrophomonas maltophilia from 2007 to 2010 were included as cases, and 140 patients without lower respiratory tract infection served as controls. The case group included 22 cases with respiratory diseases, 4 with cerebrovascular diseases, 4 with cardiovascular diseases, 1 with hemorrhage of the digestive tract, 1 with acute pancreatitis, 1 with chronic kidney disease, 1 with cervical cancer and 1 with Alzheimer's disease. While the control group included 30 cases with respiratory diseases, 44 with cerebrovascular diseases, 14 with cardiovascular diseases, 2 with malignant tumors and 50 with others. Patients' information, general situation before being admitted to MICU, drug therapy, invasive procedures and hospital-acquired infection were analyzed. Conditional logistic regression was performed to identify independent risk factors., Results: Univariate analysis showed that factors such as more than 4 underlying diseases (OR = 4.63), APACHE-II score ≥ 20(OR = 10.29), stay in the general ward more than 1 week before being admitted to MICU, treatment with more than 3 kinds of antibiotics (OR = 8.03), endotracheal intubation (OR = 4.10) or tracheotomy (OR = 50.29) and mechanical ventilation (OR = 7.95) were risk factors for hospital-acquired lower respiratory tract infection by Stenotrophomonas maltophilia. Multivariate logistic regression showed that variables such as APACHE-II score (OR = 8.39), kinds of antibiotics used (OR = 5.96) and tracheotomy (OR = 28.92) were independent risk factors (P < 0.01)., Conclusions: Underlying diseases, the severity of diseases, tracheotomy, mechanical ventilation, and the use of wide-spectrum antibiotics are important risk factors for lower respiratory tract infection by Stenotrophomonas maltophilia in MICU. To identify these factors and take preventive measures earlier may be useful for decreasing Stenotrophomonas maltophilia infection-related mortality.
- Published
- 2011
8. [Effects of human Livin gene down-regulation by RNA interference on xenograft of transplantation tumor induced by SPC-A1 in nude mice].
- Author
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Chen YS, Li YT, Li HR, Chen XY, and Lin LF
- Subjects
- Adenocarcinoma pathology, Adenocarcinoma of Lung, Animals, Cell Line, Tumor, Cell Proliferation, Down-Regulation, Female, Humans, Lung Neoplasms pathology, Male, Mice, Mice, Inbred BALB C, Mice, Nude, RNA, Small Interfering, Xenograft Model Antitumor Assays, Adaptor Proteins, Signal Transducing genetics, Adenocarcinoma genetics, Inhibitor of Apoptosis Proteins genetics, Lung Neoplasms genetics, Neoplasm Proteins genetics, RNA Interference
- Abstract
Objective: To explore the in vivo inhibitory effect of Livin gene silencing by RNA interference on xenograft of lung adenocarcinoma SPC-A-1 cells in BALB/C nude mice., Methods: Three different BALB/C nude mice models were established by subcutaneously inoculating differently treated SPC-A-1 cells into 3 nude mice groups: the blank control group was inoculated with blank SPC-A-1 cells, while the negative group was inoculated with cells transfected with lentivirus-delivered negative shRNA, the experimental group was inoculated with cells with lentivirus-delivered Livin shRNA. Then the growth of tumors was observed, and the volume and weight of the tumors were measured at different time points. The curve of tumor growth was then described, and the inhibition rate was calculated. Livin gene expression in the tumor tissues was determined by RT-PCR and Immunohistochemistry. Cell apoptosis of tumor tissues was detected by TUNEL., Results: Slower tumor growth, smaller tumor volume and lighter tumor weight were observed in the experimental group as compared to the blank and negative groups (F = 70.509, P < 0.01; F = 12.821, P < 0.01). The inhibition rate of tumor volume was (59.5 ± 3.4)%, and the inhibition rate of tumor weight was (71.1 ± 5.6)%. Livinα mRNA and Livinβ mRNA expressions in the experimental group were significantly lower than the 2 control groups [(37.2 ± 1.6)% versus (63.3 ± 3.8)%, (66.1 ± 2.6)%; (29.4 ± 1.1)% versus (53.2 ± 3.4)%, (52.3 ± 3.1)% (F(α) = 45.309, P < 0.01; F(β) = 30.076, P < 0.01)]. Livin protein expression level was also significantly lower than the blank and the negative groups [(15.3 ± 2.8)% versus (51.3 ± 2.1)%, (52.5 ± 2.5)%, F = 78.92, P < 0.01]. The apoptosis rate in the experimental group was significantly higher than that in the 2 control groups [(35.4 ± 3.2)% versus (5.4 ± 1.3)%, (8.6 ± 1.5)%, F = 14.509, P < 0.01]., Conclusion: The lentivirus-delivered Livin shRNA was shown to inhibit the proliferation of transplantation tumor of lung carcinoma effectively, and Livin may be a target for gene therapy in lung cancer.
- Published
- 2011
9. [Clinical features of 127 cases of novel influenza A (H1N1) infection in Fujian Province].
- Author
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Chen YS, Weng H, Pei XY, Lin ZS, Lin TY, Lin QC, Hong XC, Li HR, Miao Y, and Chen WY
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- Adolescent, Adult, Child, Child, Preschool, China epidemiology, Female, Humans, Infant, Influenza A Virus, H1N1 Subtype, Influenza, Human epidemiology, Influenza, Human virology, Male, Middle Aged, Prognosis, Retrospective Studies, Young Adult, Influenza, Human diagnosis
- Abstract
Objective: to investigate the clinical features of 127 cases of the novel influenza A/H1N1 infection in Fujian Province., Methods: this study included 127 human cases with the novel influenza A/H1N1 infection in Fujian Province from May 2009 to July 2009. Data were collected and reviewed from hospital medical records. The statistical analyses were performed with SPSS 11.5., Results: the median age of the 127 patients (55 were females) was 21 years (range 0.4 - 58). The median incubation period was 2 d (range 1 - 12 d). The typical clinical symptoms included fever, cough, sputum, and sore throat. The duration of symptoms in patients less than 5 years old and in patients more than 5 years old were (8.2 +/- 4.1) and (5.4 +/- 3.0) d respectively, the difference between these 2 groups being significant (z = 3.182, P < 0.01). There was also a statistically significant difference in the duration of symptoms between the high-temperature group and the low-temperature group [(6.8 +/- 3.2) vs (4.8 +/- 2.1) d, Hc = 9.729, P < 0.05]. The duration of symptoms in the high, the normal and the low white blood cell groups were (6.3 +/- 4.7) d, (5.4 +/- 2.8) d, and (8.5 +/- 4.2) d respectively, but the differences were not statistically significant (Hc = 4.729, P = 0.094). However, the duration of symptoms in the higher lymphocyte count group was significantly longer than that in the lower and normal lymphocyte count groups [(6.8 +/- 3.3) vs (5.4 +/- 3.4), (5.2 +/- 3.2) d, Hc = 10.105, P < 0.01]. Chest radiography showed patchy infiltrates in 6 patients, and their duration of symptoms was longer than patients with normal chest radiography [(8.1 +/- 5.7) vs (5.6 +/- 3.1) d], but the difference was not statistically significant (z = 1.286, P > 0.05). 125 patients received antiviral treatment with oseltamivir and they all had a good prognosis. There was a statistical difference in the duration of symptoms between the patients who used oseltamivir within 48 h after disease onset and patients who used the drug beyond 48 h [(4.7 +/- 2.2) vs (7.4 +/- 4.1) days, z = 4.907, P < 0.01]. All of the patients survived., Conclusions: the clinical symptoms of this series of patients with the novel influenza A (H1N1) infection appeared to be mild. There were several factors associated with longer duration of symptoms, including aged 5 years or younger, higher fever (body temperature > 38 degrees C), higher white blood cell count and lymphocyte count. The early use of anti-retroviral treatment with oseltamivir was useful in shortening the duration. The novel influenza A (H1N1) infection was a self-limited disease, and patients with no complications had a good prognosis.
- Published
- 2010
10. [Preparation of liposomes containing extracts of Tripterygium wilfordii and evaluation of its stability].
- Author
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Li HR, Li SF, and Duan HQ
- Subjects
- Alkaloids chemistry, Cholesterol chemistry, Drug Carriers chemistry, Drug Stability, Drugs, Chinese Herbal isolation & purification, Hydrogen-Ion Concentration, Particle Size, Pentacyclic Triterpenes, Temperature, Time Factors, Triterpenes chemistry, Drug Compounding methods, Drugs, Chinese Herbal chemistry, Liposomes chemistry, Tripterygium chemistry
- Abstract
Objective: The liposomes containing extracts of Tripterygium wilfordii were prepared and the possibility of entrapment of complex chemicals by liposomes were studied., Method: The liposomes containing extracts of T. wilfordii were prepared by thin-film dispersion method, the effect of process parameters and composition of materials on the entrapment efficiency of the main components were studied. The stability of the liposomes dispersion was also evaluated., Result: The liposomes made by thin-film dispersion method were mostly small unilamellar vesicles and their particle size was 30 nm to approximately 50 nm. The optimum entrapment efficiency of tripterine and the total alkaloids were respectively 98.10% and 88.63% but the liposomes dispersion was unstable when kept at 4 degrees C., Conclusion: The complex chemicals can be entrapped by the liposomes, but its stability need to be improved furtherly.
- Published
- 2007
11. [Study on chromatographic fingerprint of extractive from Tripterygium wilfordii with supercritical carbon dioxide].
- Author
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Zhou W, Li HR, Li SF, Takaishi Y, and Duan HQ
- Subjects
- Chromatography, High Pressure Liquid methods, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Roots chemistry, Plants, Medicinal chemistry, Reproducibility of Results, Spectrometry, Mass, Electrospray Ionization methods, Carbon Dioxide chemistry, Chromatography, Supercritical Fluid methods, Plant Extracts analysis, Tripterygium chemistry
- Abstract
Objective: To establish the chromatographic fingerprint of supercritical carbon dioxide extract of Tripterygium wilfordii., Method: HPLC method was applied for quality assessment of T. Wilfordii, HPLC analysis was performed on Kromasil C18 (4. 6 mm x 250 mm, 5 microm) with the mixture of acetonitrile-1% per thousand H3PO4, as mobile phase in gradient mode. The samples were detected at UV of 267 nm with column temperature of 35 degrees C, analytic time was 80 min; Flow-rate was 1.0 mL x min(-1). The chromatographic fingerprint of ten batches of samples was determined, for establishing the chromatographic fingerprint of T. Wilfordii., Result: Indicating 27 peaks in common, identified 21 peaks with chemical reference and HPLC-MS, and the HPLC fingerprint was established., Conclusion: The method is steady and accurate with a good repeatability and can be used as a quality control method for T. Wilfordii.
- Published
- 2007
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