Search

[Objectives] The sortie generation capacity is an important index of the operational capability of an aircraft carrier and largely determined by the support operation scheduling of the carrier-based aircraft. Therefore a good scheduling of carrier-based aircrafts on the deck can effectively improve the operational capability of aircraft carrier. [Methods] This paper establishes the operation scheduling module by converting the carrier-based aircraft support operation scheduling into job-shop scheduling problem. And through improvement of initial solution, search strategy and tabu list length, an improved tabu search algorithm is proposed to solve the model, with the purpose of minimizing the makespan. [Results] The simulation test results show that the improved tabu search algorithm can solve the carrier-based aircraft support operation scheduling problem effectively, and it is better than the traditional tabu search algorithm in terms of speed calculation and result optimization. [Conclusions] The proposed algorithm provides an effective way to solve the carrier-based aircraft support operation scheduling problem.

The exploration of biomarkers predicting response to immune checkpoint inhibitors in microsatellite stability colorectal cancer can enable more patients to benefit from immunotherapy. Tumor mutational burden (TMB), POLE/POLD1 mutation, CMS classifications, MGMT methylation, and other indicators own the potential and value of predicting response to immune checkpoint inhibitors in microsatellite stability colorectal cancer. In this paper, we reviewed the related research on predictive biomarkers of immune checkpoint inhibitors in microsatellite stability colorectal cancer, provide a reference for the best treatment strategy for microsatellite stability colorectal cancer.