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Fe-Al intermetallic compounds have great potential to replace nickel-based superalloys in industry, which is attributed to their attractive properties such as low density,high specific strength,good high-temperature oxidation and corrosion resistance and especially low cost.In this paper, important advances in the application of first-principles calculations to study the effect of element doping and microalloying on the brittleness at room temperature, high-temperature strength, interface bonding, high-temperature oxidation resistance and corrosion resistance of Fe-Al intermetallic compounds and coatings were comprehensively reviewed.A theoretical calculation scheme for first-principles research on the chloride salt corrosion resistance mechanism of B2 type Fe-Al alloy was designed,and the development directions for the application of first-principles calculations to study Fe-Al alloy and coatings were prospected.

Estrogen receptor (ER) is overexpressed in approximately 2/3 of breast cancer patients’ lesions. Noninvasive detection of ER in vivo and dynamic monitoring of ER are crucial for individualized treatment decision-making. 16α-18F-17β-fluoroestradiol (18F-FES) positron emission tomography (PET) has been used in a variety of preclinical and clinical studies to detect ER expression. However, there is still a lack of technical specifications in China. This technical specification was jointly written by domestic experts who had experience of 18F-FES PET imaging and was formed through consultation based on their own experience and research progress in this field both domestically and internationally. This technical specification introduced the synthesis method and quality control requirements of 18F-FES, recommended its clinical application scenarios, and classified them. In addition, experts’ suggestions were provided throughout the entire process systemically and detailly, including pre-imaging preparation, imaging process, image analysis (normal biological distribution, determination of ER positive and negative, lesion detection, influencing factors, false negative and false positive, report requirements), and the limitations of this imaging technique were proposed. The future application prospects were also discussed. This specification aimed to promote the standardized application of 18F-FES PET in China, achieve repeatability and comparability, and provide important molecular imaging technical support for accurate diagnosis and treatment of breast cancer.

Carbonate and fluoride co-substituted hydroxyapatite powders (CFHA) are prepared via wet chemical precipitation method, XRD, high-temperature dilatometer, SEM and the universal testing machine were used to investigate the influences of carbonate and fluoride co-substitution on the high-temperature thermal stability, high-temperature sintering properties, coefficient of thermal expansion (CET) and flexural strength of CFHA compacts. The results show that the wet CO2 atmosphere is beneficial to the thermal stability of carbonate. The weight loss mainly depends on the carbonate content, and the carbonate and fluorine substitutions have no obvious effect on the decomposition temperature of the carbonate. Carbonate substitution promotes sintering, whereas fluorine substitution Is not good for sintering. The CET of CFHA samples deceases with the carbonate and fluoride substation content, while flexural strength increases. [ABSTRACT FROM AUTHOR]

Two sets of rubber isolators in different thickness were designed and tested in laboratory to verify the feasibility. Then a full-scale two-story masonry model was constructed near a subway station in Shanghai. By verifying the kinds and layout of thick rubber isolators, four different field experimental conditions were designed to verify the effectiveness of base isolation method. Results show that; Z-vibration levels of floorslabs are decreased 19 dB maximally with base-isolation; the lower the resonance frequency, the better the human comfort inside building; the ratio of the structure's vibration isolation frequency to the floorslab's resonance frequency is the key to the design of subway vibration isolated structures; the lower the ratio, the better the effectiveness; human comfort inside base-isolated structures is controlled by the low frequency vibrations of structures' movement as a whole, though the floorslab's high frequency vibrations are reduced effectively; after base isolation method, the structure's peak velocity of particle vibration at foundation is amplified, but the influences on structure's safety still be little because modern buildings' mass is great. [ABSTRACT FROM AUTHOR]

The article presents an exploration into the anti-psychiatric movement of the 20th-century in Western society. Details are given outlining the development of the social movement resisting the influence and growth of psychiatry. Discussion is given relating the anti-psychiatry movement to a broader contemporary anti-cultural movement of the era. The movement's engagement with the rhetoric of insanity is particularly addressed. Further comments are offered connecting the anti-psychiatry movement to that of the growth of consumerism.

Objective: To investigate the effectiveness of sagittal top compression reduction technique in the treatment of thoracolumbar vertebral fractures., Methods: A retrospective analysis was conducted on the clinical data of 59 patients with thoracolumbar vertebral fractures who met the selection criteria and were admitted between November 2018 and January 2022. Among them, 34 patients were treated with sagittal top compression reduction technique (top pressure group), and 25 patients were treated with traditional reduction technique (traditional group). There was no significant difference in baseline data between the two groups ( P >0.05), including gender, age, fracture segment, cause of injury, AO classification of thoracolumbar vertebral fractures, thoracolumbar injury classification and severity (TLICS) score, American Spinal Injury Association (ASIA) grading, surgical approach, preoperative vertebral body index, height ratio of the anterior margin of injured vertebra, injured vertebra angle, segmental kyphosis angle, visual analogue scale (VAS) score, and Oswestry disability index (ODI). The operation time, intraoperative blood loss, and incidence of complications between the two groups were recorded and compared. After operation, VAS score and ODI were used to evaluate effectiveness, and X-ray and CT examinations were performed to measure imaging indicators such as vertebral body index, height ratio of the anterior margin of injured vertebra, injured vertebra angle, and segmental kyphosis angle., Results: There was no significant difference in operation time and intraoperative blood loss between the two groups ( P >0.05). No complication such as dural sac, nerve root, or vascular injury was found during operation, and all incisions healed by first intention. Patients in both groups were followed up 6-48 months, with an average of 20.6 months. No loosening, breakage, or failure of internal fixation occurred during follow-up. The imaging indicators, VAS score, and ODI of the two groups significantly improved at 1 week and last follow-up when compared to preoperative ones ( P <0.05). At last follow-up, the VAS score and ODI further significantly improved when compared to 1 week after operation ( P <0.05). At 1 week after operation and last follow-up, the vertebral body index, segmental kyphosis angle, injured vertebra angle, and ODI in the top pressure group were significantly better than those in the traditional group ( P <0.05). There was no significant difference in VAS score and height ratio of the anterior margin of injured vertebra between the two groups at 1 week after operation ( P >0.05), but the two indicators in the top pressure group were significantly better than those in the traditional group at last follow-up ( P <0.05)., Conclusion: The treatment of thoracolumbar vertebral fractures with sagittal top compression reduction technique can significantly improve the quality of vertebral reduction, and is superior to traditional reduction techniques in relieving pain and improving spinal function.

The philosophy of science yields 3 important functions in the teaching of medical history. Firstly, by analyzing the development of medicine from the perspective of philosophy, we can integrate medical history into the history of human thought and clearly show the close connection between the development of humanity and the development of medical science. Secondly, philosophical analysis on the general rules of scientific discoveries involved in medical history can help medical students to understand the methodology in the research of sciences in history. Thirdly, philosophy of science offers new dimensions for understanding the relationship between medicine and the society. By making use of the relevant theory in scientific philosophy to explore the relationship between medicine and the society, the nature of medicine and the social nature and function of science can be further understood by medical students so as to exert an active role in the research and clinical work in the future.