1. [Progress on the study of NLRP3 inflammasome in autoinflammatory diseases of children].
- Author
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Li Y and Lu M
- Subjects
- Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized, Caspase 1 immunology, Humans, Interleukin 1 Receptor Antagonist Protein therapeutic use, Hereditary Autoinflammatory Diseases drug therapy, Hereditary Autoinflammatory Diseases immunology, Inflammasomes immunology, NLR Family, Pyrin Domain-Containing 3 Protein immunology
- Abstract
Autoinflammatory diseases (AID) in childhood is one of refractory diseases, whose pathogenesis is not completely clear. In recent years, a large number of studies have shown that NLRP3 inflammasome plays an important role in the development of AIDs in children. Inflammasome is a cytosolic multiprotein complex that can activate cysteinyl aspartate-specific protease-1 (caspase-1), to further promote the maturation and secretion of proinflammatory cytokines IL-1β and IL-18 as well as pyroptosis and regulate innate immune response. IL-1 receptor antagonist (Anakinra) and IL-1β monoclonal antibody (Canakinumab) have good therapeutic effects in children with AIDs. This article reviews the research progress of NLRP3 inflammasome in the pathogenesis of autoinflammatory diseases.
- Published
- 2017
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