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Objective: To investigate the clinical characteristics of pregnancy with pneumonia. Methods: A retrospective review of all admissions from January 1,2005 to December 30,2013 included 23 women who had been hospitalized with pneumonia during pregnancy in our hospital. 23 cases were divided into three groups according the first trimester, the second trimester and the third trimester. Data of clinical manifestations, laboratory examinations, treatment and prognosis of these patients were obtained and studied. Results: The incidence of respiratory system disease during pregnancy was 3.652%,pneumonia accounted for 0.965%,the incidence of community-acquired pneumonia (CAP) was 78.3% (18/23), hospital-acquired pneumonia (HAP) was 21.7% (5/23). 2 cases (8.7%) were in the first trimester, 10 cases (43.5%) were in the second trimester, and 11 cases (47.8%) were in the third trimester. It suggested that the incidence of pregnancy with pneumonia accompanied with the trimester. The incidences of cough, fever, and shortness of breath and expectoration were 82.6% (19/23), .2% (15/23), 60.9% (14/23) and 43.5% (10/23), and shortness of breath is particularly evident in the third trimester, the difference was statistically significant (P<0.05), but cough, expectoration, chills, fever and other symptoms has no significant differences in different trimesters (P>0.05), the differences of blood count and biochemistry index were not statistically different in the different trimesters (P>0.05). On the other hand, cases with anemia was 43.5%(10/23), which was one of the risk factors of pregnant with pneumonia. The incidence of spontaneous abortion and premature delivery were 8.7% (2/23), and mature delivery were 82.6% (19/23),and no neonatal death. Conclusions: Pneumonia may be more severe in the pregnant woman, and carries significant risk to both mother and fetus. The incidence of CAP in the third trimester is higher than in the first and second trimester, and the clinical manifestations were similar with nonpregnant women, but has higher asthma incidence in the third trimester with pneumonia. Anemia is one of the risk factors of pregnancy complicated with pneumonia. [ABSTRACT FROM AUTHOR]

The increase in intra-abdominal pressure (IAP) will lead to multiple organ dysfunctions. There will be often complicated with abdominal compartment syndrome (ACS) or intra-abdominal high pressure (IAH), if pregnancy with serious internal medical or surgical diseases, or with serious complications. Furthermore, it will lead to an increased risk of maternal and perinatal mortality. Key measures for the diagnosis and prevention of ACS or IAH is monitoring IAP, the pregnancy maternal normal IAP standards and testing methods are not yet clear, that the bladder pressure method is still the gold standard of detection maternal IAP. For severe maternal IAP monitoring, we should do early detection and early treatment to avoid the occurrence of ACS. Once diagnosis of ACS, we should do early intervention, and the surgical decompression if it proves necessary. [ABSTRACT FROM AUTHOR]

Thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening disorder. It is characterized by microan-giopathic hemolytic anemia, progressive thrombocytopenia, central nervous system disorder, fever and acute renal failure. It is caused by the absent or severe deficiency of the von Willebrand factor-cleaving protease named ADAMTS13. The pathogenesis of TTP is unknown, usually triggered after pregnancy. It causes maternal morbidity and fetal loss. Prompt aggressive management should include timely termination of pregnancy, plasma transfusion and/or plasma exchange. [ABSTRACT FROM AUTHOR]

Objective: To study the relationship between gene p53 codon 72 polymorphism and pathological scar formation occurrence after caesarean section., Methods: The method of molecular beacon with real-time PCR was applied to detect gene polymorphism of p53 codon 72 in blood samples taken from 303 pregnant women (within a week after caesarea section). The clinical visits were taken 3 times for 12th to 18th months to ascertain clinical formation of pathological scar and its relationship to genotype of p53. The chi-square method was used to analyze the relationship of p53 gene polymorphism and abnormal scar formation occurrence by statistical software SPSS 13.0., Results: Total of 303 pregnant women were assayed. 30 patients were found with pathological scar by clinical visit in the total 303 pregnant women. The genotype frequencies of total three types (C/C, C/G and G/G) of p53 gene codon 72 in patients with pathological scar are significantly different from that of normal pregnant woman. The frequency of C/C genotype in patients are higher than that of normal pregnant women (P < 0.01). The frequency of C/C genotype in these patients with pathological scar is higher (46.7%, 14/30) than C/G (33.0%, 10/30, P < 0.01) or G/G (20%, 6/30) genotype (P < 0.01). The C allele frequency in the patients is 63.7%. It is also higher than G allele (36.7%, P < 0.01). The OR value is 2.30. Therefore the C allele of p53 gene codon 72 is a risk factor for pathological scar., Conclusions: There was a certain relationship between p53 gene codon 72 C allele and pathological scar formation after caesarean section.