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The experiment aimed to investigate the protective effects of Lycium barbarum polysaccharides (LBP) on aspirin (ASA) -induced intestinal injury in mice. The twenty-four 7-week-old male Kunming mice were randomly divided into a control group, aspirin model group (ASA group), and Lycium barbarum polysaccharide group (LBP group) after seven days of adaptive feeding, with eight mice in each group. The experimental period was 12 days. In the first six days of the experiment, the control group was gavage 200 mg/kg normal saline, and the ASA group and the LBP group were gavage the same amount of aspirin. On the last six days of the experiment, the LBP group was gavage 75 mg/kg LBP, and the control group and ASA group were gavage the same amount of normal saline. The results showed that compared with the control group, the jejunal villus height (VH) of the ASA group was significantly decreased ( P<0.05) and villus height/crypt depth (VH/CD) was extremely decreased (P<0.01), the activity of superoxide dismutase (SOD) in the ileum was extremely decreased (P<0.01), the content of malondialdehyde (MDA) in the jejunum and ileum was extremely increased (P<0.01). Compared with the ASA group, the LBP group significantly decreased kidney index (P<0.05), extremely increased VH/CD in jejunum and SOD activity in jejunum and ileum (P<0.01), and extremely decreased MDA content in jejunum and ileum (P<0.01). The study indicates that LBP can enhance the antioxidant capacity of jejunum and ileum in ASA-induced intestinal injury in mice, improve intestinal morphology, and alleviate intestinal injury in mice. [ABSTRACT FROM AUTHOR]

Due to its own implicit difficulties, the local wave decomposition (LWD) algorithm cannot guarantee the completeness and orthogonality of the components, and may produce redundant components and affect the accuracy of decomposition. In order to reduce the components redundancy in LWD, independent component analysis (ICA) is introduced into LWD, so that the components are orthogonal to each other and the components redundancy can be reduced. Finally, a much better decomposition performance can be obtained. It is employed to analyze the vibration signal of rotor system with early rub-impact for extracting the weak impulsive feature. The signal is decomposed into intrinsic mode functions accurately, then the high-frequency components are analyzed by Hilbert envelope demodulation. The modulating fault feature of vibration signal of a rotor system with rub- impact fault can be extracted exactly. Analytical results of experimental data show that the proposed method is accurate and efficient. [ABSTRACT FROM AUTHOR]

Panel acoustic power contribution analysis is put forward according to panel acoustic contribution analysis methodology investigation. According to gearbox noise radiation, finite element method and boundary element method are used to construct gearbox calculation model. According to the partition regions of gearbox, panel acoustic power contribution can be obtained by every panel calculation. Then, main contribution regions of the power and peak frequency are found according to calculation results. Improvement design and analysis are carried Out based on acoustic power analysis for gearbox. It can be concluded that this method is helpful for gearbox noise control investigation and realization. [ABSTRACT FROM AUTHOR]

The frequency resolution is a very important parameter of Hilbert time-frequency spectrum analysis. Different frequency resolutions will lead to different analysis results for the same signal. But how to determine the best frequency resolution of Hilbert time frequency spectrum is seldom investigated by researchers. To determine the best Hilbert spectrum frequency resolution, a new performance estimation model is put forward for impact signal analysis in this paper. It can be used to determine the best frequency resolution of Hilbert time-frequency spectrum. In the end, signal analysis is used to testify the effectiveness of this model. [ABSTRACT FROM AUTHOR]

Combined with local wave method and graph theory, a new fault diagnosis method for reciprocating compressor is proposed based on fuzzy duality tree. Firstly using local wave method, the vibration signal from reciprocating compressor is disposed to local wave time-frequency spectra, in which the fault property of the running system is confirmed, then the vector of maximal fault information is located here. Analyzing the fuzzy duality tree, certain piece of the compressor suited to the path with, maximal fault information is found out. Application of the method to the fault diagnosis for a certain reciprocating compressor illustrates its project practicability. [ABSTRACT FROM AUTHOR]

According to signal feature extraction, Hilbert spectrum entropy(HSE) by combining local wave time-frequency analysis and information entropy is used for diesel engine vibration signal feature extraction, then for the fault diagnosis. Firstly, vibration signal is decomposed by using local wave method. Then, Hilbert spectrum can be calculated according to several intrinsic mode functions. Finally, Hilbert spectrum entropy is obtained according to time-frequency distribution. It is used as feature characteristics for diesel engine pattern recognition. The diesel engine piston-liner wear is used as an example to testify the effectiveness of this method. Compared with time information entropy and frequency information entropy, it can be concluded that the HSE is effective to evaluate the condition of diesel engine. It puts forward an effective tool for diesel engine preventative maintenance. [ABSTRACT FROM AUTHOR]

An enormous amount of international floating capital has flooded the Chinese market in the recent years. There have been two stages in the development of the scale of international floating capital inflow and the characteristics of its capital investment. In the beginning, it went into those industries of rapid growth while recently it focuses on the real property industry in the Yangtze River Delta. The volume of capital in the second stage is five times larger than that in the first stage. The massive capital inflow has brought uncertain exterior impact on China's macro economy, which can be obviously seen in nominal variables and actual variables in the economy. Five nominal variables are clearly visible: (1) Because of fixed exchange system and strict exchange rate regulation, the Central Bank has to intervene with the foreign exchange market and the supply of foreign exchange. Money supply is rapidly increasing due to the influx of floating capital. (2) RMB rate has kept stable for a long time because of the government resolute attitude in recalling part of the currency issued through stare debt either via open market operation at the secondary market or refinancing by the Central Bank. The existing ternary antinomy implies that the current exchange system is not in line with the demand of the economic development in the long run and a floating exchange system should be established. (3) The floating capital has both a direct and an indirect impact on price. The indirect shock is not evident via money supply, while the direct impact is particularly evident. (4) On the one hand, interest rate impact is an indirect process due to the contra of money supply by the Central Bank's policy. It is an exogenous variable. Therefore, interest rate shock is not very obvious. (5) The influx stimulates a highly speculative stock market, which might result in domestic economy contraction. There are two actual variables: (1) Huge implicit opportunity losses have taken place in recent years due to a steep rise in the exchange reserves. (2) The economic structure can be strongly affected. The most important task today is to weaken the anticipation of RMB appreciation. Government attitude to keep RMB rate stable alone does not eliminate the anticipation. The major task is to reform the system of RMB rate and adopt a floating RMB system, to reestablish the policy of exchange reserves and, finally, to take a more cautious attitude in capital inflow liberalization in a short time. [ABSTRACT FROM AUTHOR]

Objective: To compare the clinical therapeutic effect and the impacts on recurrence rate on chronic spontaneous urticaria (CSU) between the combined treatment of bloodletting therapy and auricular point sticking on the base of xuanfu theory and the oral solution of levocetirizine hydrochloride., Methods: A total of 86 patients with CSU were randomized into an observation group (43 cases, 1 case dropped off) and a control group (43 cases, 3 cases dropped off). In the observation group, bloodletting therapy at Dazhui (GV 14), Feishu (BL 13), Geshu (BL 17) and Pishu (BL 20) was combined with auricular point sticking at lung (CO 14 ), kidney (CO 10 ), shenmen (TF 4 ) and heart (CO 15 ), etc. This combined treatment was given once every two days. In the control group, the oral solution of levocetirizine hydrochloride was prescribed, 10 mL each time, once daily. The treatment lasted for 4 weeks in the two groups. Before and after treatment, urticaria activity score 7 (UAS7), the score of dermatology life quality index (DLQI) and the levels of serum immune globulin E (IgE), interleukin 4 (IL-4) and interferon γ (IFN-γ) were compared in the patients between the two groups. The clinical therapeutic effect was evaluated in patients of the two groups and the recurrence rate was followed up 4, 8 and 12 weeks after treatment separately., Results: After treatment, the scores of UAS7 and DLQI, as well as the levels of serum IgE and IL-4 were all reduced as compared with those before treatment in the two groups ( P <0.05), and the level of serum IFN-γ was increased ( P <0.05). The total effective rate was 83.3% (35/42) in the observation group and was 85.0% (34/40) in the control group. There was no statistical significance for the difference in the clinical therapeutic effect between the two groups ( P >0.05). Eight and 12 weeks after treatment, the recurrence rates were 21.1% (4/19) and 26.3% (5/19) in the observation group, lower than 55.0% (11/20) and 65.0% (13/20) in the control group, respectively ( P <0.05)., Conclusion: The combined therapy of bloodletting and auricular point sticking on the base of xuanfu theory relieves the clinical symptoms, regulates the levels of serum IgE, IL-4 and IFN-γ and improves the quality of life in the patients with CSU. The clinical therapeutic effect of this combined treatment is similar to the oral solution of levocetirizine hydrochloride. But, the recurrence rate of the combined treatment of bloodletting and auricular point sticking is lower and its long-term curative effect is better.

Objective To observe effects of Jiangtang Xiaozhi Tablet (JTXZT) on homeostasis model of assessment for insulin resistance index (HOMA-IR) , insulin sensitivity index ( ISI) , expres- sions of insulin (INS) and insulin receptor (InsR) in pancreas tissues of KK-A(y) transgenic mice model of diabetes mellitus (DM). Methods KK-A(y) transgenic mice were fed with high fat forage to induce hyper- glycemic obese DM model. The C,7ice at same age were used as a normal control group (fed with e- qual volume of sterile water, n =11). Successful modeled 55 mice with DM obesity were divided into 5 groups by random digit table (11 in each group) , including the model group (fed with equal volume of ster- ile water, with no treatment) , the Pioglitazone Hydrochloride Tablet treatment group (8 mg/kg; as a posi- tive control group) , and JTXZT groups [high (10. 0 g crude drugs/kg) , middle (5. 0 g crude drugs/kg) and low dose (2. 5 g crude drugs/kg) ]. All medications were fed by gastrogavage, once per day for 8 succes- sive weeks. All mice were weighed and levels of random blood glucose (RBG) determined after 8 weeks of treatment. Blood was collected from ophthalmic vein. Levels of insulin (INS) , serum total cholesterol (TC) and triglyceride (TG) were detected. HOMA-IR and ISI were calculated. The morphological changes of pancreas tissues were extracted for performed pathological examinations. The expressions of INS and insulin receptor (InsR ) were measured by immunohistochemistry ( IHC ). Expressions of insulin receptorp βInsRP) and insulin receptor substrate-1 (IRS-1) in pancreas tissues were detected using Western blot. Results Compared with the normal control group, obesity, obviously increased blood glu- cose and blood lipids occurred in each group after modeling (P <0. 01). After 8 weeks of medication mice in the model group had put up body weight (P <0. 01) , blood glucose and blood lipids were kept on quite higher levels. Compared with the model group, body weight, serum levels of TG, INS, and HOMA-IR obvi- ously decreased in each JTXZT group (P <0. 05, P <0. 01). Besides, RBG decreased obviously lower in the high dose JTXZT group (P <0. 01). ISI obviously increased in low and high dose JTXZT groups (P < 0. 05, P <0. 01). Pathological results of HE staining in pancreas showed that atrophied islets with obvious- ly reduced numbers in the model group. They were sparsely distributed with reduced islet density.-Islet cells were compensatively hypertrophy, with degenerated vacuoles. Apoptosis of islet cells could also be seen in the model group, manifested as swollen cytoplasm and paryopyknosis. Islet number was obvious- ly increased in high and middle dose JTXZT groups, with reduced apoptosis and degenerated cells. Re- sults of IHC assay showed, as compared with the normal control group, the grey values of INS and InsR were significantly decreased in the model group (P <0. 01). Compared with the model group, IOD values of INS and InsR (IOD) were significantly increased in each JTXZT group (P <0. 05, P <0. 01). Results from Western blot showed that protein expressions of InsRP βnd IRS-1 were obviously decreased in the model group, as compared with the normal control group (P <0. 01). Compared with the model group, protein expressions of InsRP βnd IRS-1 were obviously increased in each JTXZT group (P <0. 01) , but with no statistical difference as compared with the Pioglitazone Hydrochloride Tablet treatment group (P > 0. 05). Conclusions JTXZT had obvious roles in decreasing levels of blood glucose, serum lipids, and improving insulin resistance in KK-Ayt(r) ansgenic mice model with diabetic obesity. Its mechanism might involve in increasing expressions of lnsRp and IRS-1 in pancreas cells, promoting the integration of INS to its receptors, and thereby improving glucose metabolism , lipid metabolism , and IR state.

There have been very few studies on the effect of Gualou Xiebai Banxia decoction combined with Xuefu Zhuyu decoction in inhibiting apoptosis in myocardial ischemial injury caused by coronary heart disease. In this experiment, Gualou Xiebai Banxia decoction combined with-Xuefu Zhuyu decoction were used to intervene the miniature swine phlegm and blood stasis type coronary heart disease model, in order to observe the effect of the combined prescription on the myocardial apoptosis and the expressions of Bcl-2, Bax, Caspase-3, Caspase-9 in the model. Totally 15 Chinese experimental miniature swine were adopted and randomly divided into the control group, the model group and the phlegm and stasis-treating group. The model group and the stasis-treating group were fed with high fat diets for two weeks, intervened with the coronary artery injury and then given drugs and high fat diets for eight weeks. The control group was fed with ordinary diets for 10 weeks, without the coronary artery injury. After the experiment, myocardia at the juncture of infracted areas were collected and made into formalin-fixed paraffin sections. The TDT-mediate dUTP nick end labeling (TUNEL) assay was used to detect the myocardial apoptosis. The immunohistochemistry (IHC) technique was applied to detect Bcl-2, Bax, Caspase-3, Caspase-9 levels in myocardial tissues. According to the findings, the apoptosis indexes (AI) for the control group, the model group and the phlegm and stasis-treating group were 0.92%, 27.68%, 17.28%, respectively. The AI of the phlegm and stasis-treating group was significantly lower than that of the model group (P < 0.01). Compared with the model group, the phlegm and stasis-treating group showed significantly higher Bcl-2 protein expression (P < 0.01) and lower Bax, Caspase-3 and Caspase-9 protein expressions (P < 0.01). In conclusion, Gualou Xiebai Banxia decoction combined with Xuefu Zhuyu decoction have a significant protective effect against the myocardial apoptosis in miniature swine phlegm and blood stasis type coronary heart disease model.

Objective: To study the protective effect of formula of removing both phlegm and blood stasis (TYTZ) on myocardial tissues of Chinese mini-swine with coronary heart disease of phlegm-stasis cementation syndrome., Method: Totally 36 Chinese mini-swine were randomly divided to six groups: the normal control group, the model group, the Danlou tablet group, and TYTZ groups with doses of 2.0, 1.0, 0.5 g x kg(-1), with six in each group. Except for the normal control group, all of other groups were fed with high-fat diet for 2 weeks. Interventional balloons are adopted to injure their left anterior descending artery endothelium. After the operation, they were fed with high-fat diet for 8 weeks to prepare the coronary heart disease model of phlegm-stasis cementation syndrome in Chinese mini-swine. After the operation, they were administered with drugs for 8 weeks. The SOD activity and MDA content of each group were observed at the 0th week (before the experiment), the 2nd week after the high-fat diet (before the operation or drug administration) , the 6th week after the high-fat diet (4 weeks after the drug administration) and the 10th week after the high-fat diet (8 weeks after the drug administration). Meanwhile, the myocardial enzymogram test and the HE staining pathological observation were performed at the end of the experiment. The changes in the myocardial cell ultra-structure were observed under transmission electron microscope., Result: Compared with the normal control group, the model group showed significant decrease in serum SOD activity and notable increase in MDA content from the 2nd week to the end of experiment (P < 0.05 and P < 0.01). In the 10th week, the CK, LDH and CK-MB levels in serum also significantly increased in the model group (P < 0.05 and P < 0.01), with obvious structural abnormality in myocardial tissue pathologic morphology and ultra-structure. Compared with the model group, TYTZ groups showed specific increase in serum SOD activity and oblivious decrease in the MDA level (P < 0.05 or P < 0.01). Meanwhile, TYTZ could significantly decrease serum CK and LDH levels in the model group (P < 0.05 or P < 0.01), attenuate the ischemia injury of myocardial tissue, and improve the ultra-structure of cardiomyocytes., Conclusion: TYTZ shows an obvious protective effect on the myocardial injury in Chinese mini-swine with coronary heart disease of phlegm-stasis cementation syndrome. Its mechanism is related to the resistance against free radical oxidation injury and the inhibition of the lipid per-oxidation.

Objective: To explore the effect of Jiangtang Xiaozhi capsule (JXC) on morphological changes of islets and liver at rat model of type 2 diabetic mellitus and provide the experimental basis for the clinical therapy of type 2 diabetic mellitus., Method: Wister rats were fed on a diet enriched in fat and glucose to induce insulin resistan, the rats were injected intrapertoneally with a low-dose streptozotocin (STZ) twice (25 mg x kg(-1)) to induce hyperglycemia, so the successful rat model of type 2 diabetes were established. The experimental rats were divided into model group, high dose JXC group, middle dose JXC group, low dose JXC group, Erjiashuanggua group, Jinqijiangtang group and normal control group. After all the treatment groups received their own medicine for two months, all the rats were sacrificed and morphological examination on their islets and livers were performed., Result: Fatty liver in various degrees was seen in the model group and all the treatment groups, but the liver steatosis in middle and low dose JXC groups was significantly milder than that in model group (P < 0.05). Islets in the high dose JXC group were significantly more than that in the model group (P < 0.05)., Conclusion: JXC can improve significantly the pathological change in islets and liver steatosis at rat model of type 2 diabetic mellitus.