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Background and objective Thoracoscopic surgery has gradually become the major procedure for lung cancer surgery in our department. Its characteristics are minimal trauma and quick recovery, which make approximately 90% of patients discharge from the hospital after surgery. However, the postoperative complications still happen now and then. We analyzed the patients who had been hospitalized for longer than 7 days after thoracoscopic lung cancer surgery, aiming to summarize the types and risk factors of complications, and improve postoperative safety of patients. Methods The data were come from the prospective database of Thoracic Surgery Unit One in Peking Cancer Hospital, and patients that underwent thoracoscopic pulmonary surgery between Jan. 2010 and Dec. 2014 with length of stay more than 7 days were included in the study. The classifications of the complications were investigated and graded as mild or severe complications according to modified Claviengrading, the relationship between clinical factors and degrees of complications was also analyzed. Results The hospitalization of 115 cases were longer than 7 days after surgery, accounting for 10.3% (115/1,112) of the whole patients that underwent surgery during the same period. Eighty-one cases had mild complications, accounting for 7.3% (81/1,112) of the whole cases that underwent surgery during the same period and 70.4% (81/115) of the cases with prolonged length of stay; the proportions of severe complications in both groups were 3.1% (34/1,112) and 29.6% (34/115), respectively; and the proportions of complications that caused perioperative deaths were 0.18% (2/1112) and 1.7% (2/115), respectively. Among all the postoperative complications, the most common was air leakage for more than 5 days after surgery, with a total of 20 cases (1.8% and 17.4%). The other common complications were: atelectasis (19 cases, 1.7% and 16.5%), pulmonary infection (18 cases, 1.6% and 15.7%), etc. The less common complications was bronchopleural fistula (4 cases, 0.36% and 3.5%) with very high risk, and 2 cases died perioperatively due to the combination of acute respiratory distresssyndrome (ARDS). In the clinical factors, only preoperative low pulmonary function (FEV1%

Background and objective Currently, there is no consensus on the follow-up strategy (follow-up time interval and content) of non-small cell lung cancer (NSCLC) in the world, and the relevant clinical evidence is also very limited. In this study, we aimed to summarize the recurrence/metastasis sites and timings of stage I NSCLC patients based on their follow-up data, aiming to provide a basis of follow-up time interval and content for this group of patients. Methods We retrospectively analyzed the 416 stage I NSCLC patients that underwent continuous anatomic lobectomy between Jan. 2000 to Oct. 2013 in our prospective lung cancer database. According to the recurrence/metastasis sites and timings, the long term follow-up time interval and content were explored. Results The 5-yr disease free survival (DFS) and overall survival (OS) in the whole group were 82.4% and 85.4%, respectively. There were 76 cases (18.3%) had recurrence/metastasis during follow-up, among which the most frequent site was pulmonary metastasis (21 cases, 5.0%), followed by brain metastasis (20 cases, 4.8%), bone metastasis (12 cases, 2.9%), and mediastinal lymph node metastasis (12 cases, 2.9%). Among the factors that could influence recurrence/metastasis, patients with pT2a suffered from a higher recurrence/metastasis rate compared to patients with pT1 (P=0.006), with 5-yr DFS being 73.8% and 87.3%, respectively (P=0.002), and the 5-yr OS being 77.7% and 90.3%, respectively (P=0.011). Conclusion The commonest recurrence/metastasis sites of stage I NSCLC after anatomic lobectomy are lung, brain and mediastinal lymph nodes, the risk of recurrence/metastasis within 2 years were equal to that between 3 years and 5 years. The follow-up frequencies and content within 2 years could be adjusted according to T stages.

Background and objective The bone and soft tissue sarcoma can metastasize to distant sites, most commonly the lungs. Some cases can be cured by radical metastasectomy, but its role, indication and prognostic factors remains controversial. The rarity of the disease combined with the diverse number of subtypes can make bone and soft tissue sarcomas very difficult to study. There are few randomized control studies or international high volume results, and such reports in China are seldom seen. The aim of this study is to investigate surgical treatment outcomes and prognostic factors of pulmonary metastatic bone and soft tissue sarcoma patients. Methods From January 2007 to December 2015, patients with bone and soft tissue sarcoma who underwent multimodality therapy including definitive surgery for the primary lesion and at least one pulmonary metastasectomy were enrolled in the retrospective study. All the relevant clinical variables were collected, and then statistically analyzed and interpreted with the aid of univariate and multivariate Cox proportional hazard regression method. Results Totally 155 pulmonary metastasectomies in 144 patients were analyzed. Incomplete R0 resection, a less than 1-year interval from a previous surgery, more than three detected nodules; and the summed maximum diameter of more than 45 mm for pulmonary metastases were independent prognostic indicators by multivariate analysis. Conclusion We suggest that metastatic bone and soft tissue sarcoma patients can benefit most from aggressive surgical intervention of pulmonary metastasectomy. Its prognostic factors include R0 resection, a longer interval from a previous surgery, smaller total number and total size of pulmonary metastases.

Background and objective It has been drawn much attention to identify the molecular markers by immunohistochemistry (IHC) for evaluating the prognosis of non-small cell lung cancer (NSCLC) following resection. The aim of this study is to retrospectively associate ever tested IHC markers and prognosis of NSCLC after resection. Methods A total of 722 NSCLC patients underwent surgery by single surgeon team from 2008 to 2013. Twelve molecular markers had been examined by IHC and the staining signals was re-scored with unified standard. Survival analysis by univariate and multivariate was carried out to assess the significance of these markers in prognosis of NSCLC in our prospective database with strict follow-up. Results The following twelve IHC markers had been tested between 2008 and 2013, including platelet-derived growth factor receptor (PDGFR)(n=124), excision repair cross complementing 1 (ERCC1)(n=124), epithelial growth factor receptor (EGFR)(n=131), vascular endothelial growth factor receptor 3 (VEGFR3)(n=142), NM23 (n=129), MRP (n=109), P170 (n=104), TS (n=143), Tubulin (n=133), ribonucleotide reductase M1 (RRM1)(n=131), ribonucleotide reductase M1 (COX2)(n=138), and TOPII (n=127). Only VEGFR3 expression was correlated with prognosis of the patients by univariate analysis, with 5-yrs survival rate being 77.6% and 65.0% (positive vs. negative) respectively (P=0.042). However, VEGFR3 was not an independent prognostic factor for this series of NSCLC patients in multivariate analysis. Conclusion These twelve IHC markers could not predict prognosis of NSCLC patients after surgery in our series.

Background and objective It has still been controversial to treat N2-IIIa non-small cell lung cancer (NSCLC) patients by surgery or non-surgery. We retrospectively analysed the survival of 121 stage N2-IIIa NSCLC patients treated with surgery and explored their postoperatively long-term prognostic factors. Methods All of 1,290 patients in Beijing Cancer Hospital underwent resection by single-surgeon-team, among which 121 cases with stage N2-IIIa were enrolled in the study. We retrospectively analysed the impact of gender, age, smoking, perioperative chemotherapy, incision, histological type, vascular tumor emboli, pTstage and tumor size on survival of stage N2-IIIa patients, and compared the survival between patients with single-and multi-station N2 metastasis, and between intraoperatively or postoperatively pathological N2 (IIIa1/a2) and preoperative N2 (IIIa3/a4). Univariate analysis was conducted by Kaplan-Meier curve, and significance test was performed by Log-rank test and Cox regression factor analysis was applicated for multivariate analysis. Results The 5-yr of all the 121 cases was 43.6%, with a median survival time being 50.3 mo. Univariate analysis showed the 5-year survival rate in patients with single- and multi- station N2 metastasis were 58.3% and 25.5%, respectively (P=0.001), 5-year survival rate in patients with stage IIIa1/a2 and stag IIIa3/a4 were 52.7% and 38.4%, respectively (P=0.020). Multivariate analysis demonstrated that only single station N2 (HR=0.326, 95%CI: 0.186-0.572, P

Background and objective A debate has been ongoing whether non-small cell lung cancer(NSCLC) with neuroendocrine(NE) differentiation likely indicates malignant behavior, poor prognosis, and sensitivity to chemotherapy. In response to this issue, we retrospectively investigated NE differentiation in NSCLC patients who underwent anatomical pulmonary surgery. Methods A total of 274 patients who met the inclusion criteria through January 2000 to December 2008 were enrolled in this study because they had the detailed material and enough paraffin tumor samples for tissue microarray. The recommended antibody panel consisted of CgA, Syn, NCAM, Leu-7, PGP9.5, and MAP-2. We also counted Ki-67 in the tissues to present the nuclear proliferation index. The Kaplan–Meier estimator and the Cox proportional hazard model multivariate analysis were applied to observe the relationship between NE differentiation and postoperative survival of the patients. Results The Cox analysis of different NE score combinations on the prognosis of NSCLC after surgical treatment did not reach statistical significance (score 1, score 2, and score≥3 vs score 0, P=0.527; score 0 vs score ≥1, P=0.791; score

In the context of cooperative vehicle-infrastructure systems (CVIS), vehicles often offload computational tasks to roadside units (RSUs) for execution due to their own constrained computing resources. A novel approach that has garnered increased attention involves the "vehicle-edge-cloud" framework, wherein RSUs decide whether to process tasks locally or to offload them to the cloud. The open and unpredictable nature of the wireless channels on the "edge-cloud" interface necessitates the incorporation of a security mechanism to safeguard the integrity of information transmission. However, integrating such a security mechanism can escalate the energy consumption of RSUs. Addressing the challenge of jointly optimizing roadside energy consumption and information security utility, without compromising task delay constraints, is a complex issue. To tackle this, an energy-packets queue tradeoff of task scheme and encryption strategy (EPTS) was introduced. This approach involved the development of a vehicle speed state model, a task encryption model, a data cache queue model, and a task calculation model, along with the formulation of an optimization objective function. The optimization model was subsequently transformed using Lyapunov optimization theory and was reformulated as a knapsack problem for resolution. The simulation results confirm the EPTS's commendable convergence and effectiveness. The average objective value achieved by the proposed EPTS was found to be 17% superior to that of the Equal Allocation Strategy (EAS) and 21% superior to the queue-weighted strategy (QS).

In this study, a mixture of ultrasound or microwave pretreated walnut meal protein peptides and CaCl2 was used for the preparation of walnut peptide-calcium chelate. The effects of different pretreatments on the calcium chelating capacity, structural changes and stability of walnut meal protein peptides were analyzed. The results showed that compared with walnut meal protein peptide-calcium chelate (WPP-Ca), the chelation rates of ultrasound-pretreated walnut meal protein peptide-calcium chelate (UP-WPP-Ca) and microwave-pretreated walnut meal protein peptide-calcium chelate (MP-WPP-Ca) were enhanced, which indicated that ultrasound and microwave pretreatments improved the calcium-chelating capacity of the peptides effectively. Using ultraviolet-visible (UV-Vis) absorption spectroscopy and Fourier transform infrared (FTIR) spectroscopy, it was found that ultrasound and microwave pretreatments mainly affected the calcium ion binding sites such as amino groups, carbonyl groups, carboxyl groups, amide bonds and carboxylate groups of walnut meal protein peptides. The results of X-ray diffraction (XRD) showed that ultrasound and microwave treatments changed the molecular arrangement of walnut meal protein peptides, thereby making the structure of walnut peptide-calcium chelate more ordered. Fluorescence spectroscopy showed that ultrasonic and microwave treatments promoted the chelation between aromatic amino acids and calcium ions. In addition, UP-WPP-Ca and MP-WPP-Ca showed good stability toward different pH values, temperatures, and gastrointestinal digestion. In short, ultrasonic and microwave pretreatments can improve the calcium-chelating capacity and stability of walnut meal protein peptides, which is of guiding significance for the processing of walnut peptide-calcium chelate and the development of calcium supplements.

Objective: To research the chemical constituents from the aerial parts of Medicago sativa., Methods: Various column chromatographies were emoployed to isolate and purify the constituents. Their structures were elucidated by spectral analysis (IR, UV, MS, 1H-NMR, 13C-NMR) and chemical evidence., Results: Two constituents were obtained and identified as soysaponin I (I), azukisaponin V (II)., Conclusion: These two compounds are isolated from the arial parts of Mesicago sativa for the first time. Moreover,the compounds are found to have hypolipidemic activity.

Objective: To observe the effects of Cinnamyl aldehyde (CA) on NIH3T3 cell cycle and explore the possible mechanism further., Method: Flowcytometry was used for observing cell cycle distribution. Expressions of proliferation cell nuclear antigen (PCNA) and Cyclin D1 protein in NIH3T3 cells were assessed by immunocytochemistry., Result: After culture with CA for 24 hours, the percentage of populations of S phase was enhanced by 3% (P < 0.05) and cell proliferation index (PrI, S + G2/M) was increased by 3.5% (P < 0.01) , but G2/M phase had no obvious changes. The expressions of Cyclin D1 and PCNA proteins were improved markly by CA compared with controlgroup (P < 0.01)., Conclusion: CA could promote more cells in G0/G1 phase into S phase, which may be related to the regulation of the expressions of PCNA and Cyclin D1.