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Left ventricular mechanical dyssynchrony (LVMD) is one of the manifestations of abnormal left ventricular motion. And the measured indexes related to LVMD are the indexes derived from left ventricular strain, which can predict the response to cardiac resynchronization therapy and the prognosis of the patients with acute myocardial infarction. The premise of LVMD diagnosis is to measure segmental strains of left ventricle accurately. As an emerging cardiac imaging technology, cardiac magnetic resonance (CMR) can accurately measure the strain of each left ventricle segment, which makes it valuable in both clinic and scientific research. In this article, the mechanism of LVMD, the measurement by CMR and its clinical application to heart diseases are reviewed. [ABSTRACT FROM AUTHOR]

Objective To understand the malaria epidemic characteristics in Hubei Province from 2015 to 2019, so as to provide the evidence for adjusting the strategies in the post-elimination stage. Methods The data from the Disease Reporting Information System of Chinese Center for Disease Control and Prevention were analyzed, with the descriptive epidemiological method for the epidemiological characteristics of malaria in Hubei Province from 2015 to 2019. Results During 2015 to 2019, a total of 645 malaria cases were reported in Hubei Province, all reported cases were imported from overseas, 456 were infected with falciparum malaria (70.7%), 78 with vivax malaria (12.1%), 88 with ovale malaria (13.6%), 20 with quartan malaria (3.1%) and 3 with mixed infection (0.5%). The top 5 cities with highest number of imported malaria cases were Wuhan (222, 34.4%), Yichang (85, 13.2%), Huangshi (60, 9.3%), Huanggang (46, 7.1%), Xiangyang (45, 7.0%). The peak of disease onset mainly occurred in January to February, in July and in November. 84.3% (544/645) of the whole cases were concentrated in 20-<50 age groups. There were 621 male cases and 24 female cases, with a sex ratio of 25.9. 1. The patients first selected diagnosis units were mainly concentrated in medical institutions, 452 (70.1%) cases were diagnosed with malaria at initial doctor visited. 43.9% of the cases were diagnosed as malaria within 24 hours after seeing a doctor. The proportion of cases with a time interval of ≥4 d from initial diagnosis to confirmed showed a decreasing trend. Imported malaria cases were mainly confirmed by prefecture-level medical institutions, accounting for 33.6%. During 2015-2019, all imported malaria cases of Hubei province were came from 39 countries distributed Africa, Asia, Oceania and South America. The imported cases came mainly from Congo-Kinshasa (118), Nigeria (73), Angola (53), Ethiopia (48) and Republic of Congo (39). Conclusions During 2015-2019, the imported malaria cases were reported in Hubei Province every year, therefore the surveillance system of malaria must be continue to work for strengthen the achievement of malaria elimination in Hubei Province. [ABSTRACT FROM AUTHOR]

The unreasonable resource allocation and lower resource use efficiency for rice-wheat double cropping system in Jianghuai region resulted from climate change severely limit the coordinated development of annually high yield and high efficiency crops. Optimizing seasonal resource allocation through sowing date adjustment is an important way to tap the annual high-yield potential and improve resource use efficiency. To quantify the effects of sowing date of rice and wheat on annual yield and resource allocation and utilization efficiency, field experiments were conducted in 2013-2015. Results showed that compared with the conventional rice-wheat cropping system (T 2 ), the two seasons appropriate late-cast cropping system (T 3 ) could coordinate resource allocation in the two seasons through the sowing date adjustment, and transfer the redundant radiation and heat resources in the wheat season to the rice. The distribution rate of accumulated temperature, radiation and rainfall resources for T 3 were: rice season accounted for 60.5%, 46.5% and 56.7%, wheat season accounted for 36.3%, 50.0% and 40.9%, and the ratio between two seasons was 1.67, 0.94 and 1.39, respectively. Rice yield and its proportion of annual production were significantly increased. The wheat yield was significantly decreased, with the variation range being smaller than that of rice. The total annual yield was increased by 336.3 kg·hm -2 as compared with T 2 . The temperature, radiation and rainfall production efficiency for rice in T 3 were increased by 9.8%, 5.6% and 8.3% in compared to T 2 , respectively. There was no significant difference in the climate resource utilization efficiency of wheat season. The annual resource production efficiency of T 3 was increased by 4.8%, 3.1% and 6.0% over the T 2 , respectively. Earlier (T 1 ) or latest sowing (T 4 ) of two seasons cropping system was not appropriate for annual yield formation and resource utilization. In summary, improving resource utilization efficiency in rice season is the key way to increase annual grain yield potential in Jianghuai region. The results provided theoretical and practical bases for the excavation of yield potential of the regional annual cropping system and the adjustment of planting structure.

Objective: To understand the malaria epidemic situation in Hubei Province from 2010 to 2014, so as to provide the evidence for formulating the effective malaria elimination strategies and measures in this province., Methods: The data from the Disease Reporting Information System of Chinese Center for Disease Control and Prevention were collected and analyzed with the descriptive epidemiological method for the epidemiological characteristics of malaria in Hubei Province from 2010 to 2014., Results: A total of 997 malaria cases were reported in Hubei Province from 2010 to 2014, there were 618 cases of vivax malaria, 352 cases of falciparum malaria, 18 cases of Plasmodium ovale infection, and 9 cases of Plasmodium malariae infection. Among all the reported cases, 479 were local cases and 518 were imported cases. No local malaria cases were reported from Hubei Province since 2013. The overall imported malaria cases showed a gradual increasing trend from 2010 to 2014, the proportion of falciparum malaria increased quite significantly from 2010 to 2014. The malaria cases were mainly distributed in Xiangyang, Wuhan, Xiaogan, Yichang, Jingmen and Suizhou cities, reaching 81.85% of the cases of the whole province. There were 810 male cases and 187 female cases, with a sex ratio of 4.33:1. The local malaria cases were mainly aged from 40 to 69 years, accounted for 78.29% of the total local cases, and 88.22% (457/518) of the whole local cases were concentrated in 20-49 age groups. The local cases were mainly farmers (67.01%). Among the imported malaria cases, the occupation distribution concentrated mainly on the worker, migrant worker, and farmer (63.90%)., Conclusions: The local malaria epidemic situation has been effectively controlled in Hubei Province, which reflects the initiative achievements of malaria elimination. However, there are still many imported malaria cases from abroad. Therefore, the imported malaria from abroad still remains the key of malaria control in Hubei Province.

Objective: To predict the incidence of local malaria of Hubei Province applying the Autoregressive Integrated Moving Average model (ARIMA)., Methods: SPSS 13.0 software was applied to construct the ARIMA model based on the monthly local malaria incidence in Hubei Province from 2004 to 2009. The local malaria incidence data of 2010 were used for model validation and evaluation., Results: The model of ARIMA (1, 1, 1) (1, 1, 0) 12 was tested as relatively the best optimal with the AIC of 76.085 and SBC of 84.395. All the actual incidence data were in the range of 95% CI of predicted value of the model. The prediction effect of the model was acceptable., Conclusions: The ARIMA model could effectively fit and predict the incidence of local malaria of Hubei Province.

Objective: To explore the endemic situation of malaria in Hubei Province in 2013, so as to put forward effective elimination strategies and measures., Methods: The data of malaria cases were searched from the Disease Reporting Information System of Chinese Center for Disease Control and Prevention and analyzed with the descriptive epidemiological method for the epidemiological characteristics of malaria in Hubei Province in 2013., Results: A total of 129 malaria cases were reported in Hubei Province in 2013 with the incidence of 0.02/10,000, and all of them were imported cases, in which 86 cases with Plasmodium falciparum infection, 32 cases with P. vivax infection, 7 cases with P. ovale infection and 4 cases with P. malariae infection. The distribution of malaria cases was concentrated in Wuhan City (76 cases), Yichang City (10 cases), Xiangyang City (7 cases) and Huangshi City (6 cases), accounting for 76.74% of the total cases. There was no significant seasonal variation in the reporting time of the cases. Totally 99.22% of the cases were male, the age distribution concentrated mainly on 20-49 years. The occupation distribution concentrated mainly on the worker, farmer, cadre staff and migrant worker. The main original areas of the imported cases were Africa (111 cases, 86.05%) and Asia (17 cases, 13.18%)., Conclusions: There is no local malaria cases reported in Hubei Province in 2013, however, the imported malaria cases are increased. Therefore, it is necessary to further strengthen the multi-sector collaboration of vector control, while the health education should be intensified especially in the key population.

Objective: To observe the efficacy of electroacupuncture on sepsis and explore its mechanism., Methods: Fifty cases were randomized into an observation group (26 cases) and a control group (24 cases). The therapeutic programs of anti-infection, anti-shock, respiratory support and nutritional support were provided, but the drugs that might affect gastrointestinal motility were not prescribed in two groups. In the observation group, on the basic treatment as above, electroacupuncture was applied to Zusanli (ST 36), Tianshu (ST 25), Shangjuxu (ST 37), Xiajuxu (ST 39). The excretion ratio of lactulose to mannitol (L/M) in urine and serum D-lactic acid level were detected before and after treatment, as well as the time of target feeding of the patients in two groups. The efficacy was compared between two groups., Results: After treatment for 3 days, L/M was (0.083 +/- 0.020) and serum D-lactic acid was (0.155 +/- 0.196) mmol/L in the observation group, which were apparently reduced as compared with (0.123 +/- 0.034) and (0.193 +/- 0.377) mmol/L in the control group respectively (both P < 0.05). The time of target feeding was (93.69 +/- 27.58) h in the observation group, which was shortened apparently than (118.17 +/- 40.28) h in the control group (P < 0.05). The total effective rate was 80.8% (21/26) in the observation group, which was better than 54.2% (13/24) in the control group (P < 0.05)., Conclusion: Conventional treatment combined with electroacupuncture can improve intestinal permeability in sepsis patients, recover intestinal function as quickly as possible to achieve target feeding.

Objective: To explore the intervention of aspirin and the changes of CX3CL1 and its receptor CX3CR1 in a rat model of acute pulmonary embolism (APE)., Methods: The autologous blood clot method was employed to establish the animal model of APE. A total of 64 rats were randomly divided into 4 groups: normal group (control), sham operation group (sham), model group (model) and aspirin group (aspirin). The profiles of pathology and tissue immunohistochemistry of CX3CL1 and CX3CR1 were compared at 4 h versus 72 h post-embolization., Results: At 4 h and 72 h post-embolism, hematoxylin and eosin staining of lung tissue showed a high degree of expansion of alveolar wall vessels and congestion. Furthermore, several rats had hemorrhagic infarction under light microscope. After the dosing of aspirin, hyperemia of lung tissue and the number of rats with infarction significantly decreased. Immunohistochemistry: CX3CL1 was predominantly expressed in cytoplasm and membrane while CX3CR1 in cytoplasm and nuclear membrane. Both showed strongly positive expression in the model group (++++) and slightly positive expression in the aspirin group (+). At 4 h and 72 h post-embolization, the CX3CL1 and CX3CR1-positive cell counts of the control, sham and aspirin groups were significantly less than those of the model group (P < 0.05)., Conclusion: Aspirin may improve the pathology and inhibit the expression of CX3CL1 and CX3CR1 in APE lung.

Objective: To observe the effect of intensive insulin therapy on improving the condition of critically ill patients., Methods: A prospective, randomized, controlled study involving adults receiving mechanical ventilation was performed. On admission, critically ill patients were randomly assigned to receive intensive insulin therapy (infusion of insulin only if the blood glucose level exceeded 6.1 mmol/L and maintenance of blood glucose at a level 4.4-6.1 mmol/L, IT group) and conventional treatment (infusion of insulin only if the blood glucose level exceeded 11.9 mmol/L and maintenance of blood glucose at a level 10.0-11.1 mmol/L, CT group). The blood glucose was detected every 4 hours. The days of stay in the intensive care unit (ICU), time of the ventilatory support needed, the time for retention of tracheal intubation, the morning blood glucose level (6 am), the intake of nonprotein calories per day, the dosage of required insulin per day,therapeutic intervention scoring system-28 (TISS-28) score,human leukocyte antigen (locus) DR (HLA-DR), CD4+/CD8+, the mortality rate,acute renal failure (serum creatine >221 micromol/L), bilirubinemia (total bilirubin >34.2 micromol/L),the number of patients who received red-cell transfusions,fever (temperature in mouth >38.5 centigrade) and the rate of hypoglycemia were determined and registered., Results: In a total of 116 patients enrolled, intensive insulin therapy reduced mortality rate (44.83 % with conventional treatment, compared with 12.07 % with intensive insulin therapy,P< 0.01). Intensive insulin therapy reduced the days of stay in ICU, TISS-28 score per day, time of the ventilatory support needed, time for retention of tracheal intubation, mean morning blood glucose levels (6 am) compared with those in CT group (P<0.05 or P<0.01), and patients receiving intensive insulin therapy were less likely to require intensive care. Intensive insulin therapy also raised consumption of insulin per day, HLA-DR and CD4+/CD8+ obviously (P<0.05 or P<0.01). Compare with the morbidity between two groups, the incidence of fever due to infection, acute renal failure and red-cell transfusions were higher in CT group (all P<0.01)., Conclusion: Intensive insulin therapy maintaining blood glucose at a level 4.4-6.1 mmol/L reduces mortality rate among critically ill patients.

Objective: To explore whether the nerve growth factor has protective effects on PC12 cells from injury induced by 2, 5-hexanedione., Methods: With PC12 cells as the model of neurons, different concentrations of NGF were added into the culture of PC12 cells. Then cell viability was tested with MTT. The DNA fragment was observed with agarose gel electrophoresis. The apoptosis ratio was tested with flow cytometry (FACS). The p53 protein was detected with western blot. The differences among the groups were compared., Results: Cell viabilities were increased with the increase of the concentrations of NGF (P < 0.05). The DNA fragment, the apoptosis ratio and the expression of p53 were all decreased with the increase of the concentrations of NGF (P < 0.05)., Conclusion: The NGF might have direct nutritional effects on PC12 cells, and protect them from injury induced by 2, 5 HD. Moreover, it might also have anti-apoptosis effect to some extent.