Search

Objective To study the relationship between waist-to-height ratio (WHtR) and new-onset cerebral infarction in the elderly with hypertension. Methods A total of 9 096 elderly hypertensive patients were enrolled from the Kailuan study population. Using the first occurrence of cerebral infarction as the endpoint event, a prospective cohort study was performed. According to the WHtR value of the subjects with an interval of 0.05, the subjects were divided into G1 group (WHtR < 0.45, G2 group (0.45 ≤ WHtR < 0.50), G3 group (0.50 ≥ WHtR < 0.55, and G4 group (WHtR > 0.55). The cumulative incidence rate of endpoint event in each population were statistically analyzed using the life table method. Cox proportional hazards regression analysis was used to explore the role of WHtR in the occurrence of new cerebral infarction. Model 1 was a single factor Cox proportional hazards analysis model, only considering the influence of WHtR on the risk of cerebral infarction. After adjusting sex, age, body weight, serum hypersensitive C-reactive protein, systolic blood pressure, serum triglycerides, smoking history, fasting blood glucose, alcohol consumption, high-density lipoprotein cholesterol, diastolic blood pressure, exercise, low-density lipoprotein cholesterol, educational level, antihypertensive drug history, model 2 was established to observe the influence of WHtR on the occurrence of new-onset cerebral infarction. Results The follow-up lasted (9.3 ± 2.7) years. Compared to the G2 group, multivariate Cox proportional hazards regression model showed that the hazard ratio HR(95%CI) for cerebral infarction in model 1 was 1.00(0.67 ~ 1.50), 1.29 (1.05 ~ 1.60) and 1.36(1.12-1.66) respectively in G1, G3 andG4; and that in model 2 was 1.09 (0.72 ~ 1.65), 1.24(0.99 ~ 1.54) and 1.31 (1.05 ~ 1.62) respectively in G1, G3 and G4. Conclusion The risk of cerebral infarction in the elderly with hypertension is the lowest when WHtR between 0.45 s; WHtR < 0.50, and WHtR greater than or equal to 0.55 is associated with an increased risk of new-onset cerebral infarction. [ABSTRACT FROM AUTHOR]

Macrophages play multiple roles in atherosclerosis. The progression of atherosclerosis is associated with morphological and functional changes in the lymphatic vessels of the diseased arteries, but the mechanism is not fully understood. This paper mainly reviews the origin and classification, the markers and the function of macrophage in atherosclerosis, the origin, the structure function and the markers of lymphatic vessels in atherosclerosis, the changes of arterial wall lymphangiogenesis in different stages of atherosclerotic lesions, the functional role of lymphangiogenesis in atherosclerosis, the lymphatic migration of macrophages and its mechanism involved in lymphangiogenesis, in order to provide a basis for the mechanism research and clinical treatment of atherosclerosis. [ABSTRACT FROM AUTHOR]

In order to obtain films with better mechanical properties and fracture toughness, the (TiAlCrZrNb)- Six-N (x=0, 4%, 8%, 12% and 16%) high entropy ceramic nanocomposite films with different Si contents were deposited on Si substrate by magnetron sputtering technology. The effects of Si doping on the microstructure, mechanical properties! and fracture toughness of the films were investigated by X-ray diffractometry, scanning electron microscopy, high-resolution transmission electron microscopy and Nano indentation apparatus. The results show that the mechanical properties and fracture toughness of the films increase first and then decrease with the addition of Si element, which can be attributed to the formation of nanocomposite structures. When Si content is 4%, (TiAlCrZrNb)-Six-N film has the best comprehensive mechanical properties, and Us maximum hardness and elastic modulus are 22.7 GPa and 192.0 GPa, respectively. In this case, the fracture toughness reaches the best, and the radial crack length C as 6.760 µm, The K1C was 1.77 MPa • m1/2. [ABSTRACT FROM AUTHOR]

Liver cirrhosis is the final outcome of various chronic liver diseases. In recent years, along with the rapid development of molecuar biology and cell biological engineering technology, liver regeneration based on stem cell transplantation technique has become a new research hotspot for treatment of acute and chronic hepatic failure. Here we review basic and clinical studies on different types of stem cells for the treatment of liver cirrhosis and optimal choices of the stem cell type used for transplantation based on specificity of patients' particular status. A arge number of experimental studies reveal that the technology of stem cell for the treatment of liver cirrhosis has gradually become mature with a broad prospect of application n the field of liver regeneration. This technology that holds enormous potential for treatment will bring hopes to the patients with end - stage liver cirrhosis. [ABSTRACT FROM AUTHOR]

The ship compartment partition and arrangement is the constantly repetitive work with a broad range of knowledge. Most of the previous ways are using man-machine interaction provided by software, complete the ship compartments partition by repeated design and stepwise refinement, or build equipment graphics library based on menu management through secondary development of some aided softwares, and finish the ship compartment partition by calling the graphics. Computer aid design/made (CAD/CAM) application has improved the design accuracy and contributed to improve the ship design and construction efficiency, but still these are try design methods. With the intelligent technology, expert system on ship compartment partition and arrangement design is established. Cabin intelligent design expert system based on parallel design method is a combined design process and evaluation process, and it unifies the knowledge engineering and computer aided software which is mainly based on the knowledge of the expert system, and the use of computer aided software realizes the intelligent ship design. This paper provides a theoretical basis for the solution of the main design parameters, laid a theoretical and technical foundation for seeking a new way of ship compartment arrangement design. Due to too much repetitive work, wide range of knowledge, and rules and regulations in design process being often ignored by designer, this paper puts forward an intelligent design method of fishing vessel cabin compartments, explores the cabin intelligent design method based on expert system applied in the design of the fishing vessel, provides a design method for a ship compartment design. In this paper, the overview of the development and its application in shipbuilding is analyzed, and domestic and international situation and development trend of intelligent design technology system as well as the basic theory and key technology of intelligent design such as composition, acquisition, representation and usage of knowledge are studied. According to the design features of ship compartment partition and arrangement, using expert system to solve such problems is proposed. And the theory and application genetic algorithm is introduced. Knowledge base and reasoning systems on ship compartment partition and arrangement is built. And compartments channel design is optimized using genetic algorithm. CATIA V5 software is secondary development in this system of knowledge engineering module. The overall structure and basic process framework of intelligent design is built according to compartment design features, and knowledge-based intelligent design system of ship compartments partition is developed using VB (visual basic), which is then applied to a 49.5 m tuna fishing vessel design and its accuracy and practicability of the procedures is verified. The development of the program realizes that the less data is needed to input to promote the rapid modeling ability, make the compartment in the fishing rules satisfy the specification at the same time, and at least can shorten the whole ship design cycle by 5-10 working days. It provides the theory and technology reference for the intelligent design of fishing boats. [ABSTRACT FROM AUTHOR]

Aiming at fingertip detection in a complex environment, from the two aspects of hand image segmentation and fingertip detection, a fingertip detection method based on human skeleton and depth image information is proposed. Firstly, Kinect is used to obtain the human skeleton and depth image information, the objective user is locked by the human skeleton information, and then the hand joint position of the locked user is used to extract the hand area image from the depth image. Secondly, the skeleton endpoints are searched from the hand skeleton, and the local optimal search method is proposed to optimize the results of contour convex hull computation. Finally, the fingertip position is found by combining the feature of hand contour. The experimental results show that the proposed method has good detection effect, meets the real-time requirements and can realize robust detection in a complex environment. [ABSTRACT FROM AUTHOR]

Objective We aimed to explore whether Taohongyin (peach seed, safflower, Sichuan lovage rhizome, Chinese angelica root-tip, and Chinese clematis root) treats atherosclerosis by regulating macrophage-mediated lymphangiogenesis. Methods The effective components of Taohongyin were identified by UPLC-Q-TOF-MS. RAW264.7 macrophages were transfected with a lentiviral vascular endothelial growth factor C (VEGFC) overexpression construct, a VEGFC knockdown construct (OE-VEGFC), and empty vector (OE-VEHICLE). The atherosclerotic cell model was constructed on RAW264.7 macrophages (ModelRAW264) or on OE-VEGFC (ModelOE-VEGFC) by intervention with human oxidized low density lipoprotein (20 mg/L) and lipopolysaccharide (100 µg/L). The optimal concentration of Taohongyin was determined by the CCK-8 method. A Transwell co-culture model of RAW264.7 macrophages and mouse lymphatic endothelial cells (MLECs) was constructed. Wound healing was assessed by the scratch test. Migration of cells was analyzed by a Transwell assay followed by crystal violet staining. Tube formation was analyzed by the tube formation assay. The contents of VEGFC, interleukin-6 (IL-6), and inducible nitric oxide synthase (iNOS) in the supernatant were determined by ELISA. The VEGFC content was determined by immunofluorescence labeling. The mRNA levels of VEGFC, lymphatic endothelial cell surface receptor (FLT4), podoplanin (PDPN), IL-6, and iNOS were determined by real-time fluorescence quantitative PCR. The protein expression levels of VEGFC, FLT4, HIF-1a, lymphatic vessel endothelial hyaluronic receptor 1 (LYVE-1), homeobox gene transcription factor 1 (Prox-1), IL-6, and iNOS were determined by Western blotting. Results UPLC- Q-TOF-MS identified 22 main active components in Taohongyin, in which hydroxysafflor yellow A (23.3%) and D-amygdalin (23.8%) were at the highest levels. A Taohongyin concentration of 20 mg/L was selected as the optimal concentration. The transfection efficiency of OE-VEGFC and OE-VEHICLE was more than 80%, indicating that the RAW264.7 macrophage VEGFC overexpression model was successfully constructed. Compared with the normal control group, the wound healing capacity of MLECs was significantly increased, cell migration and tube formation were enhanced (all P<0. 05), VEGFC fluorescence was increased (all P < 0.05), the contents of VEGFC, IL-6, and iNOS in the supernatant were increased (all P < 0.05), the mRNA expressions of VEGFC, FLT4, PDPN, IL-6, and iNOS were increased (all P < 0.05), and the protein expressions of VEGFC, FLT4, HIF-1α, LYVE-1, Prox-1, IL-6, and iNOS were increased (all P < 0.05) in the ModelRAW264.7 group. After intervention with Taohongyin of 20 mg/L, all the indicators were decreased (all P < 0.05). Compared with the ModelRAW264.7 group, all the indicators in the ModelOE-VEGFC group were increased (all P < 0.05). Compared with the Taohongyin+ModelRAW264.7 group, all the indicators in the Taohongyin+ModelOE-VEGFC group were increased (all P<0.05). Compared with the ModelOE-VEGFC group, all the indicators in the Taohongyin + ModelOE VEGFC group were decreased (all P < 0.05). Conclusion Taohongyin may reduce macrophage-mediated lymphangiogenesis by inhibiting the VEGFC pathway. [ABSTRACT FROM AUTHOR]

Different amounts of PTFE were doped in the process of Cr3+ electroplating to form Cr3+ composite coating. The effects of PTFE particles with different concentrations on the micro-structure and mechanical properties of Cr3+ composite coating were studied in this paper. The micro-structure and mechanical properties of Cr3+ coating were characterized and tested by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), nano-indenter and friction wear testing machine, respectively. The results show that different concentrations of PTFE had significant effects on the micro-structures and mechanical properties of Cr3+ composite coatings. When the concentration of PTFE in the plating solution was 12.5 mL/L, the current density was 35 A/dm², the pH was about 2.0, the temperature was 45 °C, and the deposition time was 20 min, the obtained Cr3+ composite coating had the best comprehensive performance, with the hardness of 6.8 GPa and the lowest friction coefficient value of 0.28. [ABSTRACT FROM AUTHOR]

The effects of Cu addition on the microstructure, corrosion resistance and mechanical properties of Ni-P-PTFE composite coatings were studied in this paper. The microstructure, corrosion resistance and mechanical properties of the coatings were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), electrochemical workstation, nano-indenter, and friction wear testing machine, respectively. The results show that Cu addition has great influence on the composition, microstructure, corrosion resistance and mechanical properties of Ni-P-PTFE composite coating. With the increase of Cu2+ concentration in the plating solution, Cu content in the coating first increased and then decreased, while the content of Ni, P, and PTFE first decreased and then increased. With the increase of Cu content in the coating, the corrosion resistance and hardness of Ni-Cu-P-PTFE composite coatings improved, while the friction performance decreased. [ABSTRACT FROM AUTHOR]

A safe and stable electro-polished solution containing concentrated sulfuric acid and ethylene glycol was investigated in this paper, which can be used to electro-polish NiTi alloy. The effects of different conditions on the microstructure and surface roughness of the electro-polished samples were investigated by changing the concentration of sulfuric acid, the electro-polishing voltage and temperature. The trend of the corrosion resistance and the radial force about electro-polished samples and the ground samples was investigated as well. The results show that the best electro-polishing condition was 7 mol/L concentrated sulfuric acid, 10 V voltage and 20 °C, respectively, which got the minimum surface roughness (112.9 nm) of the electro-polished samples. While the corrosion resistance could be improved obviously after electro-polishing by forming the passivation layer and the radial force was also controlled effectively by electro-polishing. [ABSTRACT FROM AUTHOR]

Application of the idea and spirit of delicacy management into the construction and management of the chemical experiment center has been iilustrated from aspects of experimental chemistry teaching management, equipment management and safety management, etc. The paper shows the importance, necessity, urgency and feasibility of delicacy management, and iilustrates that it is a basic approach to enhance the culture soft power of the center. Remarkable changes and effect have been obtained by the execution of delicacy management by the center, and the effective practice and experience are of universal meaning for other experiment teaching centers. [ABSTRACT FROM AUTHOR]

This paper presents quasi-static tests of six large-scale steel tube-reinforced concrete (ST-RC) composite column specimens under high axial force ratio. The effects of the number of loading cycles and the volumetric transverse reinforcement ratio on cumulative damage performance of the ST-RC columns were investigated. The test results indicate that the number of loading cycles has minimal effect on the strength capacity of the specimens. The number of loading cycles has limited effect on the deformation capacity for the specimens of which the transverse reinforcement is designed based on the volume of all stirrup-confined concrete, while it obviously affects the deformation capacity for the counterpart specimens of which the transverse reinforcement is designed based only on the volume of the stirrup-confined concrete of RC encasement. When the lateral loading reverses ten cycles at each displacement level, the former specimen shows obviously larger deformation and cumulative energy dissipation capacities than the latter. The ultimate displacement and failure displacement of the former are 25% and 41% larger than those of the latter, and the total cumulative energy dissipated by the former is 2.8 times that of the latter. Allowing for the effect of cumulative damage of structures subjected to ground motions, the recommendation is made that the transverse reinforcement for the ST-RC columns should be designed based on the volume of all stirrup-confined concrete for ensuring adequate deformation capacity of the columns. [ABSTRACT FROM AUTHOR]

"Psychocardiological disease" is a common and frequently-occurring disease in the department of cardiology with dysfunction of spleen in transportation as the important pathogenesis. In recent years, a large number of studies have found that mitochondrial energy metabolism disorders are related to the occurrence of psychocardiological disease. The characteristics of the function of " spleen" and mitochondria are similar to a large extent. The essence of spleen deficiency is mitochondrial dysfunction. In clinical practice, invigorating the spleen and replenishing qi, and activating the spleen and draining dampness can significantly improve the symptoms of psychocardiological disease and alleviate mental disorders while improving mitochondrial function. This paper will explore the mechanism of treating psychocardiological disease from the perspective of spleen based on energy metabolism disorder of mitochondria so as to provide reference for the clinical treatment of the psychocardiological disease. [ABSTRACT FROM AUTHOR]

In order to explore the influence of the thickness of Ni-P transition layer on the preparation of Ni-P-PTFE coating on stainless steel surface. Ni /N-P /Ni-P-PTFE three-layers structure gradient coating was prepared on stainless steel by electroplating combined with electroless plating. Scanning electron microscopy (SEM), X-ray diffraction (XRD), nano indentation, friction and wear tester, scratch tester and contact angle tester were used to characterize and test the microstructure, mechanical properties, adhesion and anti-adhesion property of the gradient coating. The results showed that, with the increased of N-P transition layer deposition time, the transition layer gradually thickened, the PTFE content in N-P-PTFE first decreased and then increased, the hardness and adhesion of N-PTFE coating first increased and then decreased. The maximum values of hardness and adhesion reach to 4.18 GPa and 13.49 N respectively when the N-P deposition time was 20 min. When the N-P deposition time was 25 min,the friction coefficient reached the minimum value of 0.17, and the contact angle between the surface of Ni-P-PTFE coating with water-based and oil-based liquid reached the maximum value of 101.1° and 60.06° respectively. At this time, the Ni-P-PTFE coating showed excellent adhesion resistance. [ABSTRACT FROM AUTHOR]

Using induction heating method, in this paper, a kind of operational and uncomplicated process was explored, by which large diameter thin-walled aluminum alloy and copper pipe could be welded. The effect of welding current, welding-length and welding high temperature insulation time on large diameter thin-walled copper aluminum tubes was studied. The microstructures of the interface were observed by scanning electron microscope (SEM) and polarizing microscope (PM), and the interfacial reaction products were analyzed by X-ray diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX). When the heating time was 6 s and weld length was 15 mm, the quality of copper aluminum welded pipe was the best, and the tensile strength was highest. The copper-aluminum intermediate compounds layer were only Al2 Cu and AlCu, and no Al4Cu9-type compounds had been found. [ABSTRACT FROM AUTHOR]

Objective To explore methylation CpG binding protein-2 gene mutation, s pathopoiesia effect on 4 suspected Rett syndrome (RTT) patients and gene sequencing's significance in assist diagnosing RTT. Methods Selected 4 suspected RTT patients admitted in Chengdu Women's & Children's Central Hospital from April to August,2014,i.e. case 1,2,3,4. Case 1 was family propositus,case 2 was case 1's mother,case 3 and 4 were sporadic patients,pedigree was successively A,B,C. Did clinical data analysis, pedigree investigation, karyotype analysis on 4 patients. Did polymerase chain reaction amplification sequencing on patients and their parents' MECP2 gene. Results Case 1 and 4 were confirmed by the latest 2010 Revised RTT diagnostic criteria and genetic diagnosis. Case 2 and 3' s clinical diagnosis was disconfirmed but virulence gene mutation was discovered. Case 1 and 2 were the first case that mother and daughter both had RTT in our country, and their MECP2 gene sequencing was the same mutation site that has not been reported in our country. Pathogenic site mutation that has been reported was discovered in case 3 and 4's pedigree. Conclusion RTT clinical diagnosis might be different from gene diagnosis. Gene diagnosis has a great value in confirming RTT,espe-cially those have nontypical clinical symptoms. Suspected patients can reduce medical cost, start rehabilitation training early, and assist prepotency by complete gene diagnosis at an early stage. [ABSTRACT FROM AUTHOR]

Concerning the problem of the large-scale unmanned system swarm intelligence control (SIC) method, this paper sketched the significance of swarm intelligence in large-scale unmanned system control and gave an overview of all kinds of SIC methods and related research works. The local rules control method was the basis of SIC, its key lay in the design and description of the internal local rules. The soft control method was based on without-destroying the local rules of system, added controllable individual into swarm to realize external control or interventions. The pilot control method realized SIC by the guiding action of informed information or higher degree of intelligence individuals. The artificial potential control method described the interaction among individuals and between individuals and environment by a potential function. Finally, this paper pointed out the application trend of various control methods and the problems needed to be studied further. [ABSTRACT FROM AUTHOR]

Magnified preparation of the catalyst was studied in this paper. Activity and stability of the catalyst were evaluated through long period, and deactivation mechanism of the catalyst was studied. The study result showed that average conversion of CO and H2 reached 99. 9% and 9.8% respectively, average selectivity of CH4 attained 98. 5%, and the activity of application catalyst was stable after continuous running of 1 000 hours. Deactivation mechanism study of the catalyst showed that the causes of catalyst deactivation with long period operation were carbon deposition and sintering, in which sintering is the main factor resulting in the decrease of catalyst activity. [ABSTRACT FROM AUTHOR]

The current rotor rig for single rotor test is modified for the experiment of tandem twin rotors. By the PIV technique, the measurements on the rotor blade-tip vortices for tandem rotors in both hover and forward flight have been carried out. The interactions between the twin rotors and their influences on blade-tip vortices are investigated by altering the longitudinal and axial distances between the twin rotors and thus changing the overlapping area. It is shown that the axial displacement of the tip vortex gradually increases with the longitudinal distances between the two rotors in hover, but the change of radial displacement of the tip vortex is not the same, and it reaches the minimum value when the longitudinal distance is about equal to 1.8R. On the other hand, when the axial distance between the two rotors is modified, the tip-vortex displacement in axial and radial directions are also changed, but the change are smaller. [ABSTRACT FROM AUTHOR]