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Quantifying similarity between nodes is a fundamental and challenging task in many fields of complex network. The similarity measure based on neighborhood nodes only considers the information of neighbors. The similarity measure based on path considers the information of path, which makes large nodes become general node. In order to more accurately measure the similarity between nodes and avoid the majority of nodes being similar to large nodes, this paper defines the distance distribution of each node, and based on this, it proposes a node similarity measurement method based on distance distribution and relative entropy (DDRE). The DDRE method generates the distance distribution of each node through the shortest path between nodes. According to the distance distribution, the relative entropy between nodes is calculated and the similarity between nodes is obtained. The experimental results of 6 real network data sets show that the DDRE method performs well in both the symmetry and the ability to affect other nodes in the SIR model.

Objective: To evaluate the clinical effect of combination of autologous tissue reconstruction of tarsal plate with temporal flap on repair of full-thickness lower eyelid defect. 
 Methods: Eleven patients (11 eyes) underwent hard palate mucosa or ear cartilage combined the emporal flap with the orbicularis oculi muscle to repair full-thickness defect of palpebra inferior. Of the 11 patients, 6 had more than 75% eyelid defect area, and 5 had more than 50% eyelid defect area. 
 Results: All 11 eyes closed completely, with no entropion or ectropion, and returned to normal basically. Postoperative follow-up was performed for 6 months to 5 years, 3 years and 4 months on average. The function and form of eyelid remained stable. Infection, leakage or contracture was not found on reconstruction tarsus. 
 Conclusion: Reconstruction of eyelid with autogenous hard palate mucosa or ear cartilage combined the emporal flap with the orbicularis oculi muscle is a simple, convenient and effective method.

Objective: To explore effects of trehalose as a cryopreserve agent on survival rate of fatty tissue after cryopreservation.
 Methods: The liposuction was used on the abdomen of adult female. After centrifugation and purification, adipose was randomized into the following three groups, the trehalose group, the fetal bovine serum (FBS)+10%DMSO group and the physiological saline group. The specimens were cryopreserved at -196 ℃ for 3 months and then the HE staining, glucose transfer method and CK method were used to detect the cell survival rate in each group.
 Results: The activity of adipose in the trehalose group and FBS+10%DMSO group adipose was higher than that in the physiological saline group (P<0.05); while there was no significant difference between the trehalose group and FBS+10%DMSO group (P>0.05).
 Conclusion: As cryoprotectant, trehalose could keep fat cell viability, and adipose tissue can be used for clinical transplantation after 3 months' freezing.