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At present, the research on air launch technology at home and abroad focuses on the numerical simulation and aerodynamic characteristics in the process of rocket separation, while the research on the impact of air launch on the payload of launch vehicle is rarely involved. The influence of the initial state of air-launch on the payload of the launch vehicle is studied. By simplifying the model of the flight orbit, the mathematical model of the rocket flight is first established and then the influence of the launch height and the launch velocity on the payload of the rocket after entering the orbit is quantitatively analyzed. The results show that increasing the launch height can effectively increase the payload, but if the launch height is increased beyond 10 km, the increase in payload is not as significant as before. Increasing the launch velocity can significantly increase the payload, and the launch velocity is more significant for the payload increase. Therefore, considering the economics of air-launch, it is more appropriate to set an initial launch height of 10 km and to increase the initial launch speed as much as possible.

Objective: To analyze the clinical features of a Chinese pedigree affected with tuberculosis sclerosis and explore its molecular pathogenesis., Methods: Clinical data of the proband and members of his pedigree were collected. Whole exome sequencing was carried out to detect variants of the TSC1 and TSC2 genes. Candidate variants was verified by Sanger sequencing and bioinformatic analysis., Results: The proband and his mother, who also had mild features of tuberous sclerosis, were found to harbor a novel heterozygous c.4183C>T (p.Q1395X) variant of the TSC2 gene, which was absent in the 4 healthy relatives. Bioinformatic analysis suggested the variant to be likely pathogenic., Conclusion: The heterozygous c.4183C>T (p.Q1395X) variant of the TSC2 gene probably underlay the disease in this pedigree. Above finding has expanded the spectrum of TSC2 gene variants. The more severe symptoms in the proband may be attributed to phenotypic heterogeneity of this disease.