Search

In this review, several mechanisms of antihypertensive peptides derived from food and its by-products were summarized. Mechanisms based on the RAAS system such as ACE/Ang Ⅱ/AT1R signaling pathways and ACE2/Ang (1-7)/MasR signaling pathways were included. Mechanisms targeting at KNOS system including PI3K/Akt/eNOS signaling pathway, PPAR-γ/caspase3/MAPK/eNOS signaling pathway and L-type Ca2+ channel were also discussed. In addition, the pathways of reducing blood pressure by inhibiting endothelin-converting enzyme (ECE) activity discovered in recent years were also introduced.

In order to solve the problem of low first time yield rate of engine clearance size in aircraft assembly plant C Six Sigma DMAIC (define, measure, analyze, improve and control) method was introduced to analyze the engine installation process. Multiple regression analysis and other methods were used to determine the key factors affecting the clearance size and their influence degree, and the optimal parameter range was obtained by linear fit-ting, and a detailed control plan was made. The analysis results of the control chart show that the improved clear-ance size is in a stable state of the process, and the first time yield rate of engine installation has increased from 65.2% before the improvement to 95%. Conclusion:quality control based on Six Sigma DMAIC method has a pos-itive effect on reducing production process variation and improving production efficiency.

In order to improve the activity of Pd catalyst for methanol catalytic oxidation, carbon fiber cloth was prepared by pre-oxidizing PAN/CA fiber cloth and heat-treated at 1 200 ℃, and the surface was loaded with different content of Pd. The microscopic structure of CNFs/Pd catalyst sample and performance testing were analyzed to find the effect of Pd catalyst. The results showed that the performance of the catalyst for electrocatalytic oxidation of methanol increased firstly and then decreased with the concentration increase of the PdCl2 solution. When the concentration of the PdCl2 solution was 0.02 mol/L, the catalyst performance was the best, and its performance and stability were about 3.3 and 10 times of the commercial Pd/C catalyst. Compared with the commercial catalyst, the activity and stability are both improved.

In the final assembly stage of military aircraft,there are problems of high control cost caused by the disconnection between quality control and business process and the lack of advanced quality planning. To solve these problems,insufficient quality planning and high control costs in the military aircraft final assembly stage,APQP(Advanced Product Quality Planning)application guide suitable for the military aircraft final assembly stage is proposed by improving the APQP guidance material of the IAQG(International Aerospace Quality Group),including theoretical models,core content and key elements,etc. The application effect of the military aircraft assembly APQP in process optimization and management,risk identification and control are verified on the aero-engine installation. The results show that the military aircraft assembly APQP is beneficial to predict and reduce risks,reduce process changes,improve military aircraft quality and delivery efficiency.

In order to investigate the effect of carbonization temperature on the electrocatalytic performance of CF/Pd catalysts for methanol oxidation, a series of CF/Pd catalysts were prepared by electrospinning heat treatment carbonization impregnation method. The carbonization temperatures were set at 800, 1 000, and 1 200 ²C, respectively. The obtained CF/Pd catalyst samples were characterized by microscopic morphology, composition analysis, and electrochemical testing. Research has found that at 800 ²C, PAN/CA fibers have completely carbonized, but as the carbonization temperature increases, the degree of fibrosis of CF/Pd catalysts gradually decreases, and the bonding phenomenon becomes more obvious. The electrocatalytic performance of methanol oxidation shows a trend of first increasing and then decreasing. When the carbonization temperature is 1 000 ²C, the CF/Pd catalyst has the best electrocatalytic performance for methanol oxidation, with a catalytic activity 5.4 times that of commercial Pd/ C catalysts and a stability 16. 2 times that of commercial Pd/C catalysts. [ABSTRACT FROM AUTHOR]

The comprehensive experiment of selective adsorption and purification of toluene and naphthalene with carbon-based adsorbent is designed, which takes the closed cabin such as manned spacecraft as the application scenario. Based on the difference of molecular polarity and molecular size between toluene and naphthalene, carbon-based adsorbents with different pore structures were prepared and the adsorption performance evaluation experiment was carried out. The adsorbents were characterized by modern instrumental analysis methods such as X-ray diffraction, nitrogen adsorption, scanning electron microscope and Fourier infrared spectroscopy, and the selective adsorption mechanism of toluene and naphthalene on the pore structure and surface properties of the adsorbents was explored. The experimental results show that the adsorption selectivity of carbon-based adsorbent for toluene and naphthalene depends on the relationship between pore size and adsorbate molecular size. With the increase of pore size, the adsorption selectivity of naphthalene is higher than that of toluene. And the higher the content of micropores, the more the adsorption performance of naphthalene is affected by toluene. [ABSTRACT FROM AUTHOR]

Background: It has been proven that metastasis-associated in colon cancer 1 (MACC1) is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC)., Methods: MACC1 and c-met expressions were detected in 103 cases of NSCLC and 40 cases of neighboring normal lung cancer tissue using immunohistochemistry., Results: MACC1 and c-met expressions were significantly higher in lung cancer tissues than that in neighboring normal tissue (P<0.001). MACC1 and c-met expressions were associated with poor differentiation, advanced T stages, lymph node metastasis, and advanced TNM stages (P<0.05) of NSCLC, but not with sex, age, smoking, and histological classification (P>0.05). In addition, a positive correlation between MACC1 and c-met expressions was observed (r=0.403, P<0.001). The result from the Kaplan-Meier survival analysis showed that the five-year survival rate in patients with positive MACC1 and c-met expressions was remarkanly lower than that in patients with negative expressions (P<0.05). The result from the Cox regression analysis showed that MACC1 expression was an independent prognostic factor for NSCLC (P=0.026)., Conclusions: MACC1 and c-met have an important function in the differentiation, invasion, and metastasis of NSCLC. MACC1 and c-met have poor prognosis in patients with NSCLC. Moreover, MACC1 expression is an independent prognostic factor for NSCLC.