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Exosomes are a kind of extracellular vesicles that play the role of transmitting information among cells. Through transporting of substances to regulate the physiological and pathological functions of various cells, it can affect the progress of malignant tumors. Natural killer (NK) cell is an indispensable part of the human immune system, and is important in the development of cancers. In the tumor microenvironment, tumor-derived exosomes (TDEXs) can act on NK cells, adjusting their functions, and modifying the interaction between NK cells and other immune cells, resulting in the change of the immune response. In recent years, the research on the relationship between NK cells and tumor exosomes has become a hot topic. The effects of TDEXs from different cancers on the activities of NK cells are summarized in this paper. [ABSTRACT FROM AUTHOR]