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Objective: To study the expression and clinical significance of Bcl -2, BAG -1, Ki -67, ER and PR on premenopausal and postmenopausal endometrial polyps. Methods: The expression of Bcl-2, BAG-1, Ki-67, ER and PR in 30 cases premenopausal endometrial polyps and 30 cases postmenopausal endometrial polyps tissues were detected by immunohistochemistry. Results: Bcl-2, BAG-1 and Ki-67 were higher expression in endometrial polyps than control group (P< 0.05), but no signification difference among ER and PR expression(P>0.05). Ki-67 expression in postmenopausal endometrial polyps was significantly lower than premenopausal endometrial polyps tissues (P<0.05). There were no signification difference among Bcl-2, BAG-1, ER and PR expression between premenopausal and postmenopausal endometrial polyps (P>0.05). Correlation analysis showed that Ki-67 was positively correlated with PR on postmenopausal endometrial polyps (P<0.05), and there was no correlation among other groups (P>0.05). Conclusions: Bcl-2, BAG-1, Ki-67, ER and PR may play an important role at different period of endometrial polyps pathological changes. [ABSTRACT FROM AUTHOR]