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2 results on '"Nitrobenzoates"'

1. [Synthesis and biological evaluation of 2-(3-butynoicamidophenyl) benzothiazole derivatives as antitumor agents].

Author

Yin GL, Li Y, Tang K, Jin XF, Chen XG, Li L, and Feng ZQ

Subjects
Antineoplastic Agents chemical synthesis, Benzothiazoles chemical synthesis, Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Nitrobenzoates, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Benzothiazoles pharmacology
Abstract

A series of 2-(3-butynoicamidophenyl)benzothiazole derivatives were synthesized starting from 4-fluoro-3-nitrobenzoic acid. Structures of all the synthesized compounds were confirmed by 1H NMR and HR-MS. Their antitumor activities against human tumor cells lines (HCT116, Mia-PaCa2, U87-MG, A549, NCI-H1975) were evaluated by MTT assay. The results revealed that most of the synthesized compounds showed potent activities against HCT116, Mia-PaCa2, U87-MG tumor cells lines. Particularly, compounds 14c and 14h exhibited better activity with IC50 values of 1 x 10(-8) mol x L(-1) against U87-MG and HCT116 respectively. The structure-activity relationship of compounds was also discussed preliminarily.

Published
2014

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