1. [Comparison of therapeutic effects in severe nocturia: gradual versus immediate drug withdrawal].
- Author
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Tang FZ, Liu YL, Wen FQ, and Zhang ZX
- Subjects
- Adolescent, Child, Deamino Arginine Vasopressin administration & dosage, Drug Administration Schedule, Female, Humans, Male, Nocturnal Enuresis etiology, Nocturnal Enuresis drug therapy
- Abstract
Objective: To investigate possible differences in the prognosis in children with severe nocturia who received different drug withdrawal schedules., Methods: Ninety-seven children with severe nocturia were randomly assigned to two groups: control (n=47) and observed (n=50). The control group accepted drug withdrawal immediately, while the observed group accepted dose tapering gradually after a 12-week treatment course. The frequency of enuresis was observed three months after complete drug withdrawal., Results: During the treatment, the frequency of enuresis in all of children from both the control and the observed groups was reduced by over 90%. Forty-six children (92%) from the observed group showed the frequency of enuresis was reduced by over 90%, but 28 children (60%) from the control group (p<0.01) three months after the complete drug withdrawal. There were no significant differences in the adverse effect and the medication compliance between the two groups., Conclusions: The different schedules of drug withdrawal may lead to different prognosis, and the schedule of gradual drug withdrawal may be superior to the immediate one in children with nocturnal enuresis.
- Published
- 2010