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Protein phosphatase magnesium-dependent 1δ(PPM1D) is a potential prognostic marker and therapeutic target for hepatocellular carcinoma. But its carcinogenic mechanism and prognostic value have not been fully elucidated. To gain insightful information of PPM1D protein, bioinformatics methods are applied to analyze the hereditary conservation, tissue expression, subcellular localization, chemical properties, space structure and protein interaction networks of PPM1D protein. The PPM1D protein is comprised of 605 amino acid residues which belong to the PP2C super family. It is a hydrophilic unstable protein without signal peptide and trans-membrane region. It is mainly located in the nucleus and the main secondary structure elements are random coil. It contains several phosphorylation, acetylation, methylation and ubiquitination sites. Interactive proteins with PPM1D are mainly cell cycle checkpoint proteins and cell damage and repair-related proteins.We analyze the relationship between PPM1D protein and cancer and the theoretical basis of PPM1D as the cancer marker, which provide some references for further study of the protein and its participation in signal pathways. [ABSTRACT FROM AUTHOR]