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BACKGROUND With the continuous accumulation of data resources around the world, the application of data visualization has become more urgent, and the methods of data visualization have also shown diversified characteristics. Data visualization is a scientific and technical research on the visual representation of data, which studies how to display relatively obscure data visually in a real and accurate way, to vividly and intuitively express the information and rules contained in the data. Literature is an important carrier of knowledge dissemination, with systematic characteristics, continuity, a large quantity and fast update, and is an important source of information. The visualization research of literature is of great significance to the dissemination of knowledge. At present, the visualization research of document data is mostly combined with the bibliometric analysis method, which visualizes the relationship between documents in the form of a scientific knowledge map. The application of this technology and method has played an important role in mining the information and rules contained in document data, but it is slightly insufficient in the spatial attribute mining of document data, which requires in-depth research in this field. OBJECTIVES To provide new solutions for expanding the application of literature data in the field of spatial visualization, thereby further enhancing the usable value of literature data. METHODS GIS technology was used to carry out the research on the spatial visualization method of document data, excavate the common content features and spatial features of document data, and gather the structured document data of a certain volume of spatial feature information to lay the data foundation for the visualization research. At the same time, the combination point between GIS technology and document data was studied, and the strategy and technical route for information mining and spatial visualization of document data were formed. Taking the data of more than 140 Re-Os isotope dating documents published since 2015 to 2020 as an example, the application test of this technical method was carried out. A Re-Os isotope data visualization service system with a five-tier architecture including layers of support, data, service, application and user has been developed, to realize the spatial visualization application of Re-Os isotope dating document data results. RESULTS The results show that: (1) The study area contains more than 140 ore producing areas that carried out Re-Os isotope dating research from 2015 to 2020, covering the eastern, central, and western regions of China. (2) There are 19 main minerals in the study area, mainly copper (29.0%), molybdenum (28.3%), tungsten (12.4%) and gold (11.0%). (3) There are 12 kinds of detection objects, and the proportion of molybdenite as the detection object is 80.7%, which indicates that molybdenite is still the preferred research object of the Re-Os isotope dating method, which is inseparable from the high Re/Os value of molybdenite. (4) The detection age falls in the lower age range of 0-200Ma, accounting for 62.1% of the ore-producing areas, which are mainly distributed in the northeast and southeast regions of China, indicating that the Re-Os isotope ages in the eastern region are concentrated in the Mesozoic era, which is consistent with the existence of large-scale Mesozoic mineralization events in the eastern region of China. The ore-producing area in the age range above 200Ma accounts for 37.9%, which is mainly distributed in the central and western regions of China, indicating that the Re-Os isotope ages in the central and western regions are concentrated before the Mesozoic era and have the characteristics of multiple mineralization. CONCLUSIONS The research shows that the document data visualization technology and method proposed in this paper can be used to excavate the spatial characteristics of the document data, expand the application of the document data in the field of spatial visualization, and solve the problems of how to analyze and extract the common information of the document data, locate the spatial feature information, and realize the spatial visualization technology. In terms of revealing important target areas, key research minerals and main application technologies, it can provide spatial visualization information, and provide reference for finding the hot spots and difficulties of current metallogenic chronology research.

In this study, the effect of annealing atmosphere on the electrical properties, optical properties, microstructure and defects of ZnO∶Al films was investigated in detail. The crystallization, surface and fracture morphologies, electrical properties, resistivity, transmittance, Raman vibration and photoluminescence of ZnO∶Al films were characterized by SEM, XRD, Hall effect test instruments, ultraviolet-visible spectrophotometer, Raman spectra and PL spectra. The results show that after annealing in air atmosphere, the carrier concentration of AZO films decreases from 1.63 × 1020 cm−3 to 7.1 × 1018 cm−3, the optical band gap varies from 3.51 eV to 3.37 eV, the transmittance in NIR increased and the band edge emission in PL spectrum shifted from 3.49 eV to 3.34 eV. On the other hand, while the carrier concentration of AZO films annealing in H2 atmosphere was 5.3 × 1020 cm-3, the optical band gap increases to 3.78 eV, the transmittance in NIR decreases remarkably, the emission intensity of the band edge increases by more than 10 times and the band edge emission in PL spectrum shifts to 3.57 eV. Furthermore, the 4 order LO phonons are observed in ZnO:Al films annealed in air.

Background and purpose: The expression of programmed death ligand-1 (PD-L1) in lung cancer not only is the most important biomarker for predicting the efficacy of programmed death-1 (PD-1)/PD-L1 inhibitors, but also may affect the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) targeted therapy. However, there are currently few reports in the relevant literature on whether the expression of PD-L1 in lung cancer can affect the efficacy of chemotherapy in patients with lung adenocarcinoma. This study mainly explored the effect of PD-L1 expression in lung adenocarcinoma on the efficacy of pemetrexed-based chemotherapy and its underlying mechanism. Methods: From Oct. 2015 to Dec. 2018, 185 eligible lung adenocarcinoma patients treated in Department of Pathology, The General Hospital of Western Theater Command PLA were enrolled. The expressions of PD-L1 and thymidylate synthase (TS), a molecule predicting the efficacy of pemetrexed-based chemotherapy, were detected by immunohistochemistry. The survival curve of patients was drawn by Kaplan-Meier method. The log-rank test and COX regression model were used to analyze the clinicopathological factors affecting the patients’ progression-free survival (PFS) and overall survival (OS). The log-rank test was used to analyze the effects of PD-L1 and TS expressions on the patients’ PFS and OS. Spearman rank correlation test was used to analyze the correlation between PD-L1 expression and TS expression in lung cancer tissues. Western blot and real-time fluorescent quantitative polymerase chain reaction (RTFQ-PCR) were used to detect the protein and mRNA expressions of PD-L1 and TS in 6 types of lung adenocarcinoma cell lines. The Pearson correlation test was used to analyze the correlation between PD-L1 and TS at protein expression level and mRNA expression level. Results: Among 51 patients with advanced lung adenocarcinoma who received pemetrexed-based chemotherapy as first-line treatment, the objective response rate (ORR) of the PD-L1 positive group was 20.0%, and the disease control rate (DCR) was 60.0%. There was no significant difference compared with the PD-L1 negative group (ORR: 20.0% vs 35.5%, χ 2 =1.404, P=0.236; DCR: 60.0% vs 80.6%, χ 2 =2.602, P=0.107). The median PFS (mPFS) of patients with negative expression of PD-L1 was significantly better than that of patients with positive expression of PD-L1 (mPFS: 5.6 months vs 4.1 months, log-rank=5.406, P=0.020), and there was no significant difference in median OS (mOS) between them (mOS: 15.9 months vs 12.7 months, log-rank=0.525, P=0.469). Univariate analysis found that the positive expressions of PD-L1 and TS were risk factors for PFS ［PD-L1 negative vs positive: HR=2.002 (1.100-3.645), P=0.023; TS negative vs positive: HR=2.205 (1.367-4.587), P=0.003］. Multivariate analysis found that TS positive expression was an independent risk factor for PFS ［TS negative vs positive: HR=3.245 (1.091-9.652), P=0.034］. Among the 51 patients with advanced lung adenocarcinoma who received pemetrexed-based chemotherapy as the first-line treatment, the expression of PD-L1 in cancer tissues was significantly positively correlated with the expression of TS (r s =0.691, P

[Objective] This study screened proper storage pattern for long-term storage of bottled domestic red wines to provide evidence for their scientific storage. [Method] Different storage patterns of bottle position (vertical or horizontal) and storage conditions (cabinet, cellar or room) were applied and the effects on color parameters, chemical components and aromatic characteristics of Cabernet Sauvignon red wines were examined during 14 months of storage. [Result] Storage patterns had significant impacts on color and sensory quality of Cabernet Sauvignon wines during storage. Bottle position was less effective than storage conditions. Room storage had greatest effects, followed by wine cellar and wine cabinet. During the first 9 months of storage, wine color stability and aroma complexity were improved with the increase of temperature. After storage for 14 months, aging characteristics appeared in samples stored in room condition, such as highlighted yellow color hue and aged red wine aroma, while wines stored in cabinet kept intense ruby color and red berry aroma. The correlation analysis further showed that the changes were mostly related to oxidation occurred in wine samples, and higher storage temperature accelerated the aging of red wine. [Conclusion] The color and sensory evolution of Cabernet Sauvignon wines were closely related to oxidation during bottle storage, resulted from the combination of oxygen, storage temperature and time. Low temperature and horizontal position are suggested for long-term storage. [ABSTRACT FROM AUTHOR]

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