Search

For studying the influence of different rolling processes on the microstructure morphology and internal stress of pipeline steel， the temperature field and stress field of steel plate under different processes were studied by rolling process experiment and thermal mechanical coupling numerical simulation. Subsequently， the microstructure morphology and internal stress of steel plate were tested and analyzed by metallographic microscope and XRD. The results of an actual measurement of the surface temperature of steel plate showed that the error between the simulated value and the measured value was small， and the temperature field calculated by numerical simulation was reasonable，which could be the basis for stress field analysis. After the steel plate was water-cooled for 20 s，the maximum and minimum temperature differences between the steel plate core and corner were 318 ℃and 211 ℃respectively. The maximum and minimum stress difference between the core and corner of the steel plate was 417 MPa and 260 MPa respectively. In addition， the obtained microstructure was composed of bainite，martensite and ferrite. It could be concluded from the results of experiments and numerical analysis that， it was reasonable to control the final rolling temperature at 800～900 ℃and the cooling rate at 20 ～25 ℃/s. Under these process parameters， the phase transformation nucleation rate of the steel plate was high， the internal stress difference was small， and a mixed microstructure comprising of martensite， bainite and ferrite was finally formed.

The problem of data incompleteness has become an intractable problem for network representation learning(NRL) methods,which makes existing NRL algorithms fail to achieve the expected results.Despite numerous efforts have done to solve the issue,most of previous methods mainly focused on the lack of label information,and rarely consider data imbalance phenomenon,especially the completely imbalance problem that a certain class labels are completely missing.Learning algorithms to solve such problems are still explored,for example,some neighborhood feature aggregation process prefers to focus on network structure information,while disregarding relationships between attribute features and semantic features,of which utilization may enhance representation results.To address the above problems,a semantic information enhanced network embedding with completely imbalanced labels(SECT)method that combines attribute features and structural features is proposed in this paper.Firstly,SECT introduces attention mechanism in the supervised learning for obtaining the semantic information vector on precondition of considering the relationship between the attribute space and the semantic space.Secondly,a variational autoencoder is applied to extract structural features under an unsupervised mode to enhance the robustness of the algorithm.Finally,both semantic and structural information are integrated in the embedded space.Compared with two state-of-the-art algorithms,the node classification results on public data sets Cora and Citeseer indicate the network vector obtained by SECT algorithm outperforms others and increases by 0.86%~1.97% under Mirco-F1.As well as the node visualization results exhibit that compared with other algorithms,the vector distances among different-class clusters obtained by SECT are larger,the clusters of same class are more compact,and the class boundaries are more obvious.All these experimental results demonstrate the effectiveness of SECT,which mainly benefited from a better fusion of semantic information in the low-dimensional embedding space,thus extremely improves the performance of node classification tasks under completely imbalanced labels.

Gastrin releasing peptide receptor (GRPR) is overexpressed in various tumors, and these GRPR-positive tumors have successfully and widely been targeted with GRPR antagonists. To achieve a good therapeutic effectiveness and less radioactive dosage administration, high cellular internalization is required. The cellular internalization of agonists is better than that of antagonists, but the severe side effects of agonists restrict their applications. In this study, we hypothesized that introducing membrane penetrating oligo-phenylene-ethynylene (OPE) to GRPR antagonist RM26 could increase the cellular internalization of antagonists. Therefore, two multi-functional compounds NOTA-OPE-1-RM26 and NOTA-OPE-2-RM26 were synthesized and labelled with 177Lu with high efficiency. The 177Lu labelled compounds 177Lu-NOTA-OPEs-RM26 were stable in saline, dulbecco’s modified eagle medium (DMEM) and newborn bovine serum. The in vitro experimental results indicated that the introduction of OPE-1 slightly increased the cellular internalization of the radiolabelled compounds while OPE-2 significantly increased the cellular internalization. In addition, the introduction of OPEs did not change the specific binding ability of RM26. The investigations indicated that introducing the OPE to increase the internalization was feasible.

According to the complex nonlinear properties of hydraulic excavator arm's servo system, a Hammerstein model which contains static nonlinearity and dynamic linearity was adopted to describe the system instead of linear model. The dynamic linear module was described by a discrete Auto-Regressive eXogeneous (ARX) model, and the static nonlinearity module was described by a two-segment polynomial. The forgetting factor recursive least square method was applied to realize decomposition identification of the parameters for both linear and nonlinear module through multi-frequency sinusoidal input and angle output signal. The comparison experiments between the identified Hammerstein model and ARX model indicated that the error of Hammerstein model was reduced by 77%, the results demonstrated that Hammerstein model meets the need for describing the servo system of excavator arm. [ABSTRACT FROM AUTHOR]

The results of Micro-FTIR spectra analysis of the euhedral faceted polycrystalline diamonds (EFPCDs) from the Western Yangtze Craton show that the EFPCDs are mostly IaAB type, the concentration of nitrogen.varies greatly from 25. 70- 358.35 μg x g(-1). Different nitrogen content distributes in different diamond grains or position in same sample. The C Center was not found in the samples and the conversion from A center to B center is incomplete, in the meanwhile, B% value concentrated in 40%. Thus, polycrystalline diamonds are not formed in the stage of nucleation but gathered together after formation of the individual diamond grains during the residence time in the mantle. And its formation environment is. more complex than the euhedral faceted polycrystalline diamonds from Mengyin kimberlite, the Eastern of North China Craton. The diamonds extremely possibly originated in the deep mantle from 160 to 180 km, reaching the depth of the core of the Yangtze Craton, at the same time it is close to the bottom of the lithosphere. The C-H bond of sp2 hybridization are conducive to the formation of platelets in diamonds. Meanwhile, its concentrations are generally higher than the C-H bond of sp3 hybridization in the samples.

Red pigment of continental red-bed is known originating from the fine-particle hematite in the rocks. Advance of researches on the origin of continental red-bed demonstrates that the red pigment of red-bed originated from its diagenetic but not depositional process. The high diagenetic temperature causes the dehydration of iron hydrate to form hematite, generating the red pigment. For examining the above hypothesis, the authors of this paper designed an experiment to approach the reddening process, i.e. formation of the red pigment of continental red-bed. Black ooze sampled from the Holocene sediments of the Pearl River Delta was heated in different ways. The diffuse reflectance spectroscopy (DRS) of those heated ooze samples were detected with Perkin-Elmer Lamdba 950 ultraviolet/visible/near-infrared spectrophotometer, and moreover, red-values of the samples were calculated for determining their coloring levels. Iron in black ooze sediment is predominantly in the form of goethite. Experimental results verified that initial dehydration-temperature of goethite is about 150 degrees C, either enhancing temperature or prolonging heating time is accompanied with decreasing goethite and increasing hematite, and a positive relationship exists between red-value of samples and peak-height of hematite. The experimental results strongly support the idea of thermal origin of continental red-bed.

The Guidong composite granite body (CGB) located in the north Guangdong Province consists of numerous rock bodies formed respectively in the early and late Jurassic and early Cretaceous. Analysis of the granites of different period with X-ray fluorescence spectroscopy and plasma mass spectrometry indicates: (1) From the top of a granite body downwards, the felsic components of rock decrease, while the mafic and sigmaREE, LREE/HREE, (La/Yb)N, as well as delta Eu value increase, suggesting the material differentiation in the in-situ melting of crustal rocks and crystallisation of magma; (2) From old to young of the different period granite-massifs in the Guidong CGB, the felsic compositions totally decrease, and the mafic components, sigmaEE, LREE/HREE, (La/Yb)N, and delta Eu value increase as well, implying multiple crustal melting (remelting) events in the Mesozoic in this area; and (3) Primitive mantle-normalized spider diagram for trace elements of Guidong CGB suggests high maturity of the crust involved in the in-situ melting.

Objective: To clone the human tissue factor pathway inhibitor-2 (hTFPI-2) gene and express it by using prokaryotic expression system., Methods: The hTFPI-2 coding region was obtained by RT-PCR from human placenta total RNA. The coding fragment was then inserted into prokaryotic expression vector pET19b and expressed in E. coli BL21 by IPTG induction. The produced inclusion bodies were dissolved by denaturalizing chemicals, purified by ion exchange chromatograph, and refolded in air to form proper disulfide bonds. Chromogenic and gelatin zymography methods were used to evaluate the inhibiting effects of hTFPI-2 on trypsin, plasmin and MMPs individually. The inhibitory activity of hTFPI-2 on fabrisarcoma was investigated by matrigel., Results: The coding fragment of hTFPI-2 was cloned successfully and the protein was expressed as inclusion bodies which account for 20% - 30% of total host protein. The refolded hTFPI-2 could inhibit the invasive ability of fibrisarcoma HT-1080 as well as activity of plasmin, trypsin and MMPs., Conclusions: The activated hTFPI-2 is obtained by using prokaryotic expressed system effectively.