Search

Objective:To observe the effect of sling exercise therapy on adolescent patients with idiopathic non-double-curved scoliosis.Methods:A total of 42 adolescent patients with idiopathic non-double-curved scoliosis who were treated in the department of rehabilitation medicine of Zhongda Hospital Southeast University from June to December 2019, which were randomly divided into the control group and the observation group according to the random number table method, with 21 cases in each group. The both groups were given conventional rehabilitation therapy, which including muscle and fascia relaxation in the concave spine(five minutes a time), respiratory therapy(six times per group, three groups a day, rest for 40 second between two groups), traction therapy(30 minutes a time). The control group was given mat training on the basis of conventional rehabilitation therapy, including double bridge, tummy roll, left or right plank movement, each movement training 8-10 times, continous training 4-6 groups, rest for 40-60 s between two groups. The observation group was given sling exercise therapy on the basis of conventional rehabilitation therapy, which including neutral position control training in supine position, lateral position and prone position(record the training time and terminate the exercise if patients experience pain or fatigue, each movement training 8-10 times, continous training 4-6 groups, rest for 40-60 s between two groups). The above training was conducted once every other day, three times a week, continous training for six months. Before treatment and after treatment for six months, Cobb angle was used to evaluate the severity of scoliosis; clavicular angle(CA)was used to evaluate the degree of shoulder imbalance; pelvic obliquity(PO)was used to evaluate the degree of pelvic imbalance; scoliosis research association-22 item questionnaire(SRS-22)was used to evaluate the patients'self-image satisfaction.Results:Before treatment, there were no significant differences in Cobb angle, CA, PO and SRS-22 scores between the two groups(P>0.05).Compared with before treatment, Cobb angle, CA and PO in both groups were significantly decreased, and SRS-22 score was significantly increased, with statistical significance(PP

C-RAN may be a promising way for 5G fronthaul network associated with significant changes in 5G fronthaul architecture.Based on the analysis of existing schemes such as optical fiber direct connection,passive WDM and active WDM/OTN,open wavelength division multiplexing (open-WDM) system was proposed to satisfy the new requirements of 5G fronthaul network.In the open-WDM system,WDM technology is used to save optical fiber resource and the semi-active architecture can achieve flexible deployment.The low-cost management and control technology was further applied to perform efficiently network operation.

The large-scale deployment of 5G brings bandwidth and lower delay requirements to transport network.As a 5G oriented multi-service transport platform,SPN will transport wireless service,home broadband service,enterprise service and private line service.SPN distribution layer and core layer network will need huge bandwidth and support long range transport.The SPN optical layer key technology and network scheme were studied,also implemented to verify the function and performance of SPN optical layer.

Aimed to understand the causes of the boundary formation of Quercus wutaishanica for- est, four sites were chosen along a precipitation and thermal gradient from Qinling Mountain to Lo- ess Plateau of northern Shaanxi Province, i. e. , north slope of Qinling Mountain (Jiwozi)and south- ern (Chenjiashan), central (Huaishuzhuang), and northern site (Xiasiwan) of Loess Plateau, with the gas exchange, chlorophyll fluorescence parameters, stomatal density, and stomatal size of Q. wutaishanica leaves measured. From the south to the north along the precipitation and thermal gradient, weather varied from cool and humid to warm and semi-arid, and the maximum net photo- synthetic rate (Pn max) and light saturation point (Lsp) of Q. wutaishanica leaves reduced obviously from 13.34 to 6.99 μmol CO2•m-2•s-1 and from 1489.9 to 1055.6 ?mol•m-2•s-1, dark res- piration rate ( Rd ) and light compensation point ( Lcp ) increased evidently from 0.313 to 1.080 μmol CO2•m-2•s-1 and from 7.49 to 31.96 μmol•m-2•s-1, the minimum fluorescence (Fo) and coefficient of non-photochemical quenching (NPQ) displayed an increasing trend, and actual photochemical quantum yield of PS∥(ΦPS∥), apparent electron transport rates (ETR), and coefficient of photochemical quenching (qP ) reduced obviously. These results demonstrated that the photosynthetic capacity of Q. wutaishanica declined gradually with decreasing precipitati- on, but the stomatal density and stomatal size showed no obvious difference among the study sites except for the southern site of Loess Plateau. It was speculated that the depressed net photosynthetic rate of Q. wutaishanica leaves induced by the declined ΦPS∥and ETR could be one of the main causes for the formation of northern boundary of Q. wutaishanica forest. [ABSTRACT FROM AUTHOR]

Objective To report clinical phenotype and gene mutation characteristics of one case of early⁃onset Alzheimer's disease (EOAD) associated with PSEN2 V214L mutation and conduct a pedigree analysis. Methods and Results A 63⁃year⁃old male proband with no family history of dementia, onset at 58 years old, had memory loss as the first manifestation and progressive aggravation of symptoms. Neuropsychological tests showed a score of 1 on Mini⁃Mental State Examination (MMSE), 0 on Montreal Cognitive Assessment (MoCA), 71 on Activities of Daily Living Scale (ADL), and 3 on Hachinski Ischemic Score (HIS). Head MRI revealed extensive cortical atrophy, with prominent atrophy of bilateral hippocampal, multiple hyperintensity in deep white matter (Fazekas grade 2). Exons of high⁃throughput sequencing of dementia⁃related genes showed that both the proband and his sister had heterozygous missense mutations in exon 8 of PSEN2 gene c.640G>T (p.V214L) and heterozygous splicing mutations in exon 28 of SORL1 gene c.3815⁃4A>C. The proband was finally diagnosed with EOAD associated with PSEN2 V214L mutation, and the proband's sister was considered as an absolute risk group for Alzheimer's disease (AD). Conclusions The PSEN2 V214L mutation probably causes EOAD. Further investigations should be conducted to evaluate the effects on the production of amyloid β⁃protein 40 and 42 (Aβ40 and Aβ42), then verify its pathogenicity.

To investigate the variations and sources of n -alkanes and sugars in Taian City during summer, PM 2.5 samples were collected from July 22 to August 19, 2016. The identified n -alkane and sugar sources were investigated using a principal component analysis (PCA) multiple linear regression (MLR) model and a backward trajectory model. The results showed that the mass concentrations of PM 2.5 during summer were (37.2±11.5) μg·m -3 . The mass concentrations of n -alkanes were (83.3±34.7) ng·m -3 , the carbon preference index (CPI) was 1.83, and the relative contribution of wax n -alkanes was 34.7%-69.4%, suggesting that contributions from terrestrial plants were more significant in Taian City. The results showed that the mass concentrations of sugars in Taian City during summer were (73.4±46.6) ng·m -3 . Levoglucan, galactosan, and mannosan were the main saccharides, accounting for 64.0%, 7.1%, and 6.3% of the total concentrations of sugars, respectively, indicating that biomass burning is much more significant in Taian City. The results of the PCA-MLR model suggested that n -alkanes and sugars in Taian City during summer were mostly from terrestrial plants, coal burning and biomass burning. The backward trajectory model showed that the pollution mostly came from the native sources of Shandong province and the inland cities in the south.

Aimed to understand the causes of the boundary formation of Quercus wutaishanica forest, four sites were chosen along a precipitation and thermal gradient from Qinling Mountain to Loess Plateau of northern Shaanxi Province, i. e. , north slope of Qinling Mountain (Jiwozi) and southern (Chenjiashan), central (Huaishuzhuang), and northern site (Xiasiwan) of Loess Plateau, with the gas exchange, chlorophyll fluorescence parameters, stomatal density, and stomatal size of Q. wutaishanica leaves measured. From the south to the north along the precipitation and thermal gradient, weather varied from cool and humid to warm and semi-arid, and the maximum net photosynthetic rate (Pn max) and light saturation point (Lsp) of Q. wutaishanica leaves reduced obviously from 13.34 to 6.99 micromol CO2 x m(-2) x s(-1) and from 1489.9 to 1055.6 micromol x m(-2) x s(-1), dark respiration rate (Rd) and light compensation point (Lcp) increased evidently from 0.313 to 1.080 micromol CO2 x m(-2) x s(-1) and from 7.49 to 31.96 micromol x m(-2) x s(-1), the minimum fluorescence (F0) and coefficient of non-photochemical quenching (NPQ) displayed an increasing trend, and actual photochemical quantum yield of PS II (phiPS II), apparent electron transport rates (ETR), and coefficient of photochemical quenching (qP) reduced obviously. These results demonstrated that the photosynthetic capacity of Q. wutaishanica declined gradually with decreasing precipitation, but the stomatal density and stomatal size showed no obvious difference among the study sites except for the southern site of Loess Plateau. It was speculated that the depressed net photosynthetic rate of Q. wutaishanica leaves induced by the declined Phi PS II and ETR Could be one of the main causes for the formation of northern boundary of Q. wutaishanica forest.

Objective: Sepsis remains a serious clinical problem because of high morbidity and mortality. The importance of Toll-like receptors (TLRs) for the induction of immune responses against sepsis was demonstrated in humans. The present study aimed to probe the gene polymorphisms of TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg753Gln) in patients with sepsis among Chinese Han children in Wenzhou, and investigate the correlation with sepsis., Method: This study was conducted as a case-control study. Using polymerase chain reaction and DNA sequencing, gene polymorphisms of TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg753Gln) in 59 children with sepsis, 38 children with severe sepsis (including 20 septic shock) and 57 healthy controls were analyzed. Hardy-Weinberg method of statistics was used to compare the frequency of genotypes alleles among three groups., Result: The mutant genotypes of TLR4 gene (Asp299Gly and Thr399Ile) were not found among sepsis, septic shock and control groups. In severe sepsis group, the Arg753Gln TLR2 polymorphism occurred in 2 out of 38 severe sepsis patients and both of the subjects with the TLR2 Arg753Gln polymorphism had fatal staphylococcal infections., Conclusion: TLR4 gene (Asp299Gly and Thr399Ile) polymorphisms may not be correlated with susceptibility to sepsis among Chinese Han children in Wenzhou. The fact that only 2 out of 38 severe sepsis patients had Arg753Gln TLR2 polymorphism suggests that a larger sample size is needed because of the rarity of the TLR2 allele among Chinese Han children in Wenzhou.

Objective: To investigate the effects of intracerebroventricular (ICV) administration of streptozotocin (STZ) on the expressions of Abeta and hyperphosphorylation of tau protein in rat brain., Methods: Twenty-four adult SD rats were randomized into 2 groups to receive ICV of STZ bilaterally at the dose of 3 mg/kg (with the injection repeated on day 3) or normal saline injection in an identical manner. Twenty-one days later, the expressions of Abeta(1-40), Abeta(1-42), tau(202), tau(396) and tau(404) were investigated immunohistochemically., Results: After STZ administration, the expressions of Abeta(1-40), Abeta(1-42), tau(202), tau(396) and tau(404) increased in both the cortex and hippocampus in the rat brain., Conclusion: ICV injection of STZ increases the expression of Abeta and promotes hyerphosphorylation of tau protein.

Vascular dementia (VaD) subtypes include multi-infarct dementia, subcortical ischemic vascular dementia, strategic-infarct dementia, etc. Poststroke dementia may be related to preexisting cognitive level, and the frequency increased with aging, lower educational level and accompanied vascular risk factors. Vascular cognitive impairment (VCI) forms a spectrum that includes VaD, mixed Alzheimer's disease (AD) with a vascular component, and VCI without dementia. The concept of VCI will improve the early diagnoses and secondary prevention and treatment of VaD, and promote the further research on vascular component in neurodegenrative disorders.