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Selenium yeast is the most widely available and ideal organic selenium supplement for livestock and poultry production, with a variety of biological functions such as antioxidant, immune boosting, anti-cancer and liver protection. Recent studies have shown that selenium yeast can improve the intestinal antioxidant capacity, maintain the integrity of the intestinal barrier and regulate the immune response. This paper focuses on a review of selenium yeast in the regulation of animal intestinal health and its application in pig production, with the aim of providing a reference for basic research on selenium yeast in the improvement of animal intestinal health and the application of selenium-enriched pork in production. [ABSTRACT FROM AUTHOR]

The experiment was to screen differentially expressed genes (DEGs) in the livers of broilers supplemented with selenium yeast, to investigate the molecular mechanisms by which selenium yeast affects the growth, development, and health of broilers. The study obtained gene expression profile data from the Gene Expression Omnibus (GEO) and conducted bioinformatics mining. The results showed that 600 DEGs related to selenium yeast were identified. These DEGs were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation using DAVID software, leading to the significant enrichment of 18 biological processes and 12 KEGG pathways. A proteinprotein interaction network (PPI) was constructed using the STRING database, which included 546 nodes and 905 edges. Using Cytoscape software, six hub genes (FN1, PLCG1, MYO3 A, ITGA8, KDM6 A, and ATP2 B2) and four gene modules were identified. The study suggests that these six hub genes, along with the pathways related to the adrenergic signaling in the cardiomyocytes, calcium signaling, homologous recombination, focal adhesion, and eukaryotic ribosome biogenesis in myocardial cells, may be the key genes and key pathways through which selenium yeast influences the growth, development, and health of broilers. [ABSTRACT FROM AUTHOR]

The experiment was conducted to investigate the effect of selenium yeast and probiotics on production performance and blood biochemical indices of laying hens, and to improve the performance of laying hens. A total of 800 healthy Roman laying hens aged 26 weeks were randomly divided into four groups with five replicates in each group and 40 hens in each replicate. The groups were control group （basal diet）, probiotics group, selenium yeast group and probiotics + selenium yeast group, respectively. The experiment lasted for 60 d. The results showed that compared with the control group, the qualified egg rate and average daily feed intake of probiotics + selenium yeast group were significantly increased （P<0.05）, and the feed to egg ratio was significantly decreased （P<0.05）. The activities of blood glutathione peroxidase and superoxide dismutase were significantly increased （P<0.05）. The contents of aspartate aminotransferase, alkaline phosphatase, creatine phosphokinase and lactate dehydrogenase were significantly decreased （P<0.05）, and the content of alanine aminotrans宦rase was significantly decreased （P<0.01）. The contents of total cholesterol, triglyceride and low-density lipoprotein cholesterol were significantly decreased （P<0.05）. The content of high-density lipoprotein cholesterol was significantly increased （P<0.01）, the content of urea nitrogen was significantly decreased （P<0.01）, and the content of creatinine and uric acid was significantly decreased （P<0.05）. The experiment indicates that dietary supplementation of 1 g/kg probiotics + 0.3 g/kg selenium yeast can improve liver function, lipid metabolism, protein utilization efficiency, antioxidant capacity and production performance of laying hens. [ABSTRACT FROM AUTHOR]

Objective: To evaluate if selenium yeast could inhibit the rat lung injury induced by ambient fine particulate matter( PM&#95;(2. 5) )., Methods: Fifty-six male SpragueDawley rats were randomly allocated in seven groups( n = 8 each). Saline control group, the rats were exposed to 0. 9% saline by instillation. PM&#95;(2. 5) exposure group, rats were exposed to PM&#95;(2. 5) by intra-tracheal instillation every other day for three times with the accumulated dose of 40 mg/kg. Selenium yeast treatment groups, three groups of rat were exposed to PM&#95;(2. 5) . Then the rats were given low, middle and high dose of selenium yeast, and the doses were 8. 75, 17. 5 and 35 mg/kg, respectively. High dose selenium yeast control group, rats were given high dose of selenium yeast only. Solvent control group, therats were given 1% carboxymethyl cellulose. Saline and PM&#95;(2. 5) were given in the first week. In the second week, selenium yeast and solvent were given by gavage. The rats were sacrificed 24 hours after the last gavage. The bronchoalveolar lavage fluid( BALF)was collected to count the neutrophils numbers and analyze the markers related to inflammation, oxidative stress and cell damage. The lung lobe that was not been lavaged was processed for light microscopic examination., Results: The proportions of neutrophils in BALF and the pathologic scores of lung in PM&#95;(2. 5) - exposed groups were significantly higher than control( P < 0. 05). Selenium yeast treatment caused decrease in tumor necrosis factor-α( TNF-α), interleukin-1β( IL-1β), lactate dehydrogenase( LDH), total protein( TP), alkaline phosphatase( AKP) and malondialdehyde( MDA) compared with the only PM&#95;(2. 5) exposure group. Meanwhile, the dose-dependent increase in totalsuperoxide dismutase( T-SOD) and glutathione peroxidase( GSH-Px) activities were observed. There were no significant differences among the groups of saline control group, high dose selenium yeast control group and solvent control group., Conclusion: Selenium yeast treatment may protect against acute injury induced by PM&#95;(2. 5) in rat lung.